Clinical efficacy, safety and tolerance of clindamycin phosphate gel, 1%, in the treatment of mild tomoderate acne


The authors present the results of a prospective, open-label, post-registration comparative study of the monotherapy
of mild to moderate acne with an inflammatory component. 30 subjects aged 15-35 were engaged in the study.
Subjects from Group 1 (n = 15) received Clindovit® in the form of 1% gel, and subjects from Group 2 (n = 15) received
a combination of erythromycin and zinc in the form of lotion. The duration of treatment and participation in the study
was 8 weeks. Dynamics of clinical manifestations of the disease, Dermatology Life Quality Index (DLQI), Psychological
and Social Effects of Acne (APSEA), frequency and severity of adverse events against the background of treatment
were assessed. The results of the study enabled the investigators to make a conclusion about efficacy, safety and good
tolerance of Clindovit® gel as a monotherapy of mild to moderate acne with an inflammatory component.


  1. Strauss J., Krowchuk D., Leyden J. et al. Guidelines of care for acne vulgaris management. J Am Acad Dermatol 2007; 56: 651-63.
  2. Элинг Д. Секреты дерматологии. СПб; 1999: 513.
  3. Leyden J. A review of the use of combination therapies for the treatment of acne vulgaris. J Am Acad Dermatol 2003; 49: 200-10.
  4. Cunliffe W.J., Collnick H. Diagnosis and management. 2001; 166.
  5. Ross J., Eady E., Jonathan H. et al. Clinical Resistance to Erythromycin and Clindamycin in Cutaneous Propionibacteria Isolated from Acne Patients Is Associated with Mutations in 23S rRNA. Antimicrobial agents and Chemotherapy 1997; 5: 1162-1165.
  6. Kuhlman D.S., Callen J.P. A comparison of clindamycin phosphate 1 percent topical lotion and placebo in the treatment of acne vulgaris. Cutis. 1986; 38: 203-206.
  7. Katsambas A., Towarky A.A., Stratigos J. Topical clindamycin phosphate compared with oral tetracycline in the treatment of acne vulgaris. Br J Dermatol 1987; 116: 387-391.
  8. Leyden J. Effect of topical benzoyl peroxide/ clindamycin versus topical clindamycin and vehicle in the reduction of Propionibacterium acnes. Cutis 2002. Jun; 69 (6): 475-80.
  9. Wolf J.E. Jr., Kaplan D., Kraus S.J. et al. Efficacy and tolerability of combined topical treatment of acne vulgaris with adapalene and clindamycin: a multicenter, randomized, investigator-blinded study. J Am Acad Dermatol 2003; 49: S211-217.
  10. Lookingbill D., Chalker D., Lindholm J.S. et al. Treatment of acne with a combination clindamycin/benzoil peroxide gel compared with clindamycin gel, benzoyl peroxide gel and vehicle gel. J Am Acad Dermatol 1997; 37: 590-595.
  11. Leyden J.J., Hickman J.G., Jarratt M.T. The efficacy and safety of a combination benzoyl peroxide/clindamycin topical gel compared with benzoyl peroxide alone and a benzoyl peroxide/ erythromycin combination product. J Cutan Med Surg. 2001 Jan-Feb; 5 (1): 37-42.
  12. Alirezaï M., Gerlach B., Horvath A. et al. Results of a rundomised multicentre study comparing a new water based gel of clindamycin 1% versus clindamycin 1% topical solution in the treatment of acne vulgaris. JEADV 2005; 15: 274-278.
  13. Самцов А.В. Акне и акнеформные дермато- зы. Монография. М.: ООО «ЮТКОМ», 2009; 288: илл.

Copyright (c) 2011 Samtsov A.V., Sukharev A.V., Bondar' O.I., Patrushev A.V., Nazarov R.N., Minchenko A.A., SAMTSOV A.V., SUKHAREV A.V., BONDAR O.I., PATRUSHEV A.V., NAZAROV R.N., MINCHENKO A.A.

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