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A study of the level of circulating cytokines in patients with atopic dermatitis
- Authors: Volkova Y.N.1, Morozov S.G.2, Tarasova M.V.1, Grigoriyeva A.A.3, Yelistratova I.V.4
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Affiliations:
- The Russian National Research Medical University named after N.I. Pirogov
- Federal State Budgetary Institution «Institute of General Pathology and Pathophysiology» under the Russian Academy of Medical Sciences
- State Research Center of Dermatovenereology and Cosmetology, Ministry of Healthcare of the Russian Federation
- Central Military Clinical Hospital Russian Interior Troops
- Issue: Vol 90, No 2 (2014)
- Pages: 26-30
- Section: ORIGINAL STUDIES
- Submitted: 24.08.2017
- Published: 24.04.2014
- URL: https://vestnikdv.ru/jour/article/view/17
- DOI: https://doi.org/10.25208/0042-4609-2014-90-2-26-30
- ID: 17
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Abstract
Goal of the study. To study the role of pro-inflammatory and anti-inflammatory cytokines for the course of atopic dermatitis (AD). Materials and methods. The study involved 72 patients aged 25-55 suffering from atopic dermatitis for 2-30 years and with at least two relapses a year. The AD patients were assigned to the following groups depending on the SCORAD (iSc) index: Group 1: light form (iSc < 30 points), Group 2: moderate to severe form (iSc from 30 to 50 points) and Group 3: severe form (iSc > 50 points). The control group comprised 23 practically healthy subjects aged 25-35. The level of cytokines (IL-1 β, -4, -6, -8, -10, -12, -13, TNF-α and IFN-γ) in blood serum was determined based on the immune-enzyme assay method. Results. A trend to the increased production of anti-inflammatory cytokines (IL-4, -6, -10, -13) at the exacerbation stage and increased synthesis of pro-inflammatory ones (IFN-γ, TNF-α and IL-12) at the remission stage was observed in patients with atopic dermatitis, which confirms the dysregulation of reciprocal relationships between Th1 and Th2 lymphocyte subpopulations during the disease.
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About the authors
YE. N. Volkova
The Russian National Research Medical University named after N.I. Pirogov
Author for correspondence.
Email: volkovaen@cnikvi.ru
Россия
S. G. Morozov
Federal State Budgetary Institution «Institute of General Pathology and Pathophysiology» under the Russian Academy of Medical Sciences
Email: noemail@neicon.ru
Россия
M. V. Tarasova
The Russian National Research Medical University named after N.I. Pirogov
Email: noemail@neicon.ru
Россия
A. A. Grigoriyeva
State Research Center of Dermatovenereology and Cosmetology, Ministry of Healthcare of the Russian Federation
Email: noemail@neicon.ru
Россия
I. V. Yelistratova
Central Military Clinical Hospital Russian Interior Troops
Email: noemail@neicon.ru
Россия
References
- Kozlova V.A., Sennikov S.V. Sistema tsitokinov: teoreticheskie i klinicheskie aspekty. Novosibirsk: Nauka 2004; 324. [Козлова В.А., Сенников С.В. Система цитокинов: теоретические и клинические аспекты. Новосибирск: Наука 2004; 324.]
- Revyakina V.L., Korostovtsev D.S., Dygylova N.D. Atopic dermatitis: role of cytokines. Allergology 2000; 1: 40-47. [Ревякина В.Л., Коростовцев Д.С., Дигилова Н.Д. Атопический дерматит: роль цитокинов в механизмах развития. Аллергология 2000; (1): 40-47.]
- Simbirtsev A.S. Cytokines - classification and biologic functions. Cytokines & inflammation 2004; 3 (2): 16-22. [Симбирцев А.С. Цитокины: классификация и биологические функции. Цитокины и воспаление 2004; 3 (2): 16-22].
- Eichenfield L.F, Ellis C.N., Mancini A.J. et al. Atopic dermatitis: epidemiology and pathogenesis update. Semin Cutan Med Surg 2012; 31 (3): 3-5.
- Noh G, Lee J. Atopic dermatitis and cytokines: the im-munoregulatory and therapeutic implications of cytokines in atopic dermatitis--part II: negative regulation and cytokine therapy in atopic dermatitis. Recent Pat Inflamm Allergy Drug Discov 2012; 6 (3): 248-261.
- Ketlinskiy S.A. Rol' T-khelperov tipov 1 i 2 v regulyatsii kletochnogo i gumoral'nogo immuniteta. Immunologiya 2002; 2: 77-79. [Кетлинский С.А. Роль Т-хелперов типов 1 и 2 в регуляции клеточного и гуморального иммунитета. Иммунология 2002; (2): 77-79.]
- Akdis M., Blaser K., Akdis C.A. T regulatory cells in allergy. Chem Immunol Allergy 2006; 91: 159-173.
- Akdis M., Blaser K., Akdis C.A. T regulatory cells in allergy: novel concepts in the pathogenesis, prevention, and treatment of allergic diseases. J Allergy Clin Immunol 2005; 116 (5): 961-968.
- Grewe M., Bruijnzeel-Koomen C.A., Schopf E. et al. A role for Th1 and Th2 cells in the immunopathogen-esis of atopic dermatitis. Immunol Today 1998; 19: 359-361.
- Allam J.P., Novak N. The pathophysiology of atopic eczema. Clin Exp Dermatol 2006; 31: l 89-93.
- Bacchetta R., Gregori S., Roncarolo M.G. CD4+ regulatory T cells: mechanisms of induction and effector function. Autoimmun Rev 2005; 4 (8): 491-496.
- Braathen L.R. Т-cells subsets in patients with mild and severe atopic dermatitis. Acta Derm Venereol 1985; 114: 55-60.
- Ohshima Y., Yasutomi M., Omata N. et al. Dysregulation of IL-13 production by cord blood CD4+ T cells is associated with the subsequent development of atopic disease in infants. Pediatr Res 2002; 51 (2): 195-200.
- Berke R., Singh A., Guralnick M. Atopic dermatitis: an overview. J Am Fam Phys 2012; 186 (1): 35-42.
- Lee J., Noh G., Lee S. et al. Atopic dermatitis and cytokines: recent patents in immunoregulatory and therapeutic implications of cytokines in atopic derma-titis--part I: cytokines in atopic dermatitis. Recent Pat Inflamm Allergy Drug Discov 2012; 6 (3): 222-247.
- Leung D.Y. Immunopathogenesis of atopic dermatitis. Immunol Allergy Clin North Am 2002; 22: 73-90.
- Machura E., Mazur B., Kwiecien J., Karczewska K. Intracellular production of IL-2, IL-4, IFN-gamma, and TNF-alpha by peripheral blood CD3(+) and CD4 (+) T cells in children with atopic dermatitis. Eur J Pediatr 2007; 166 (8): 789-795.
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