A study of the level of circulating cytokines in patients with atopic dermatitis

Cover Page

Cite item


Goal of the study. To study the role of pro-inflammatory and anti-inflammatory cytokines for the course of atopic dermatitis (AD). Materials and methods. The study involved 72 patients aged 25-55 suffering from atopic dermatitis for 2-30 years and with at least two relapses a year. The AD patients were assigned to the following groups depending on the SCORAD (iSc) index: Group 1: light form (iSc < 30 points), Group 2: moderate to severe form (iSc from 30 to 50 points) and Group 3: severe form (iSc > 50 points). The control group comprised 23 practically healthy subjects aged 25-35. The level of cytokines (IL-1 β, -4, -6, -8, -10, -12, -13, TNF-α and IFN-γ) in blood serum was determined based on the immune-enzyme assay method. Results. A trend to the increased production of anti-inflammatory cytokines (IL-4, -6, -10, -13) at the exacerbation stage and increased synthesis of pro-inflammatory ones (IFN-γ, TNF-α and IL-12) at the remission stage was observed in patients with atopic dermatitis, which confirms the dysregulation of reciprocal relationships between Th1 and Th2 lymphocyte subpopulations during the disease.

About the authors

YE. N. Volkova

The Russian National Research Medical University named after N.I. Pirogov

Author for correspondence.
Email: volkovaen@cnikvi.ru
Russian Federation

S. G. Morozov

Federal State Budgetary Institution «Institute of General Pathology and Pathophysiology» under the Russian Academy of Medical Sciences

Email: noemail@neicon.ru
Russian Federation

M. V. Tarasova

The Russian National Research Medical University named after N.I. Pirogov

Email: noemail@neicon.ru
Russian Federation

A. A. Grigoriyeva

State Research Center of Dermatovenereology and Cosmetology, Ministry of Healthcare of the Russian Federation

Email: noemail@neicon.ru
Russian Federation

I. V. Yelistratova

Central Military Clinical Hospital Russian Interior Troops

Email: noemail@neicon.ru
Russian Federation


  1. Kozlova V.A., Sennikov S.V. Sistema tsitokinov: teoreticheskie i klinicheskie aspekty. Novosibirsk: Nauka 2004; 324. [Козлова В.А., Сенников С.В. Система цитокинов: теоретические и клинические аспекты. Новосибирск: Наука 2004; 324.]
  2. Revyakina V.L., Korostovtsev D.S., Dygylova N.D. Atopic dermatitis: role of cytokines. Allergology 2000; 1: 40-47. [Ревякина В.Л., Коростовцев Д.С., Дигилова Н.Д. Атопический дерматит: роль цитокинов в механизмах развития. Аллергология 2000; (1): 40-47.]
  3. Simbirtsev A.S. Cytokines - classification and biologic functions. Cytokines & inflammation 2004; 3 (2): 16-22. [Симбирцев А.С. Цитокины: классификация и биологические функции. Цитокины и воспаление 2004; 3 (2): 16-22].
  4. Eichenfield L.F, Ellis C.N., Mancini A.J. et al. Atopic dermatitis: epidemiology and pathogenesis update. Semin Cutan Med Surg 2012; 31 (3): 3-5.
  5. Noh G, Lee J. Atopic dermatitis and cytokines: the im-munoregulatory and therapeutic implications of cytokines in atopic dermatitis--part II: negative regulation and cytokine therapy in atopic dermatitis. Recent Pat Inflamm Allergy Drug Discov 2012; 6 (3): 248-261.
  6. Ketlinskiy S.A. Rol' T-khelperov tipov 1 i 2 v regulyatsii kletochnogo i gumoral'nogo immuniteta. Immunologiya 2002; 2: 77-79. [Кетлинский С.А. Роль Т-хелперов типов 1 и 2 в регуляции клеточного и гуморального иммунитета. Иммунология 2002; (2): 77-79.]
  7. Akdis M., Blaser K., Akdis C.A. T regulatory cells in allergy. Chem Immunol Allergy 2006; 91: 159-173.
  8. Akdis M., Blaser K., Akdis C.A. T regulatory cells in allergy: novel concepts in the pathogenesis, prevention, and treatment of allergic diseases. J Allergy Clin Immunol 2005; 116 (5): 961-968.
  9. Grewe M., Bruijnzeel-Koomen C.A., Schopf E. et al. A role for Th1 and Th2 cells in the immunopathogen-esis of atopic dermatitis. Immunol Today 1998; 19: 359-361.
  10. Allam J.P., Novak N. The pathophysiology of atopic eczema. Clin Exp Dermatol 2006; 31: l 89-93.
  11. Bacchetta R., Gregori S., Roncarolo M.G. CD4+ regulatory T cells: mechanisms of induction and effector function. Autoimmun Rev 2005; 4 (8): 491-496.
  12. Braathen L.R. Т-cells subsets in patients with mild and severe atopic dermatitis. Acta Derm Venereol 1985; 114: 55-60.
  13. Ohshima Y., Yasutomi M., Omata N. et al. Dysregulation of IL-13 production by cord blood CD4+ T cells is associated with the subsequent development of atopic disease in infants. Pediatr Res 2002; 51 (2): 195-200.
  14. Berke R., Singh A., Guralnick M. Atopic dermatitis: an overview. J Am Fam Phys 2012; 186 (1): 35-42.
  15. Lee J., Noh G., Lee S. et al. Atopic dermatitis and cytokines: recent patents in immunoregulatory and therapeutic implications of cytokines in atopic derma-titis--part I: cytokines in atopic dermatitis. Recent Pat Inflamm Allergy Drug Discov 2012; 6 (3): 222-247.
  16. Leung D.Y. Immunopathogenesis of atopic dermatitis. Immunol Allergy Clin North Am 2002; 22: 73-90.
  17. Machura E., Mazur B., Kwiecien J., Karczewska K. Intracellular production of IL-2, IL-4, IFN-gamma, and TNF-alpha by peripheral blood CD3(+) and CD4 (+) T cells in children with atopic dermatitis. Eur J Pediatr 2007; 166 (8): 789-795.

Copyright (c) 2014 Volkova Y.N., Morozov S.G., Tarasova M.V., Grigoriyeva A.A., Yelistratova I.V.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 60448 от 30.12.2014.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies