Naftifine and therapy of fungal skin infections: 40 years of success

Cover Page


Cite item

Full Text

Abstract

The article presents the results of international and Russian clinical studies to assess the efficacy and safety of topical antimycotic drugs for the treatment of skin mycoses. The authors demonstrate the advantages of Naftifine (compliance and efficacy) as compared to other topical drugs. Taking into consideration a broad range of its action including antifungal, antibacterial and anti-inflammatory effects, Naftifine can be considered as a first-line drug for the treatment of superficial dermatomycoses including complicated with a bacterial infection.

About the authors

YE. V. Matushevskaya

Institute of Improvement of professional skill of Federal Medico-Biological Agency of Russia

Author for correspondence.
Email: matushevskaya@mail.ru
Россия

YE. V. Svirshchevskaya

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences

Email: noemail@neicon.ru
Россия

References

  1. Stepanova Zh.V. Gribkovye zabolevaniya: diagnostika i lechenie. M: Miklosh 2005. [Степанова Ж.В. Г рибковые заболевания: диагностика и лечение. М: Миклош 2005.]
  2. Ivanova M.A., Ogryzko E.V., Bendrikovskaia I.A. et al. Situation with respect to dermatomycoses in the Russian Federation in 2003-2007. Сііп Dermatol and Venerol 2009; 2: 26-31. [Иванова М.А., Огрызко Е.В., Бендриковская И.А. и соавт. Динамика заболеваемости дерматомикозами в Российской Федерации в 2003-2007 гг. Клин дерматол и венерол 2009; (2): 26-31.]
  3. Levy A. Epidemiology of onychomycosis in specialrisk populations. J. Am. Podiatr Med. Assoc. 1997; 87: 546-550.
  4. Rukovishnikova V.M. Mikozy stop. M: MSD 1999. [Руковишникова В.М. Микозы стоп. М: МСД 1999.]
  5. Sergeev A.Yu., Sergeev Yu.V. Gribkovye infektsii: Rukovodstvo dlya vrachey. M: Binom 2008; 480. [Сергеев А.Ю., Сергеев Ю.В. Грибковые инфекции: Руководство для врачей. М: Бином 2008; 480.]
  6. Leshchenko V.M., Bogush P.G., Leshchenko G.M. Kombinirovannoe lechenie rubrofitii. Usp med mikol 2003; 2: 91-92. [Лещенко В.М., Богуш П.Г., Лещенко Г.М. Комбинированное лечение руброфитии. Усп мед микол 2003; (2): 91-92.]
  7. Sergeev A.Yu., Sergeev Yu.V. Novye informatsionnye tekhnologii i distantsionnoe obuchenie patsientov - perspektivnyy sposob bor'by s massovymi mikozami cheloveka. Usp med mikol 2007; 10: 15. [Сергеев А.Ю., Сергеев Ю.В. Новые информационные технологии и дистанционное обучение пациентов - перспективный способ борьбы с массовыми микозами человека. Усп мед микол 2007; (10): 15.]
  8. Sergeev Yu.V. Mestnaya i kombinirovannaya terapiya onikhomikozov. Posobie dlya vrachey. M., 2003. [Сергеев Ю.В. Местная и комбинированная терапия онихомикозов. Пособие для врачей. М., 2003.]
  9. Rukavishnikova V.M. Epidemiologiya, patogenez, klinika, lechenie i profilaktika mikozov stop. Materia medica. Ezhekvartal'nyy byulleten' dlya vrachey i farmatsevtov. Rossiyskaya meditsinskaya assotsiatsiya. M: FARGUS PRINT 1997; 2(14): 11-40. [Рукавишникова В.М. Эпидемиология, патогенез, клиника, лечение и профилактика микозов стоп. Materia medica. Ежеквартальный бюллетень для врачей и фармацевтов. Российская медицинская ассоциация. М: ФАРГУС ПРИНТ 1997; 2(14): 11-40.]
  10. Klinicheskie rekomendatsii «Dermatovenerologiya». M, 2010; [Клинические рекомендации «Дерматовенерология». М, 2010; 435.]
  11. Ryder N.S. Specific inhibition of fungal sterol biosynthesis by SF 86-327, a new allylamine antimycotic agent. Antimicrob Agents Chemother. 1985 Feb; 27(2): 252-6.
  12. Belter A., Skupinska M., Giel-Pietraszuk M. et al. Squalene monooxygenase - a target for hypercholesterolemic therapy. Biol Chem. 2011; 392(12): 1053-75.
  13. Hantschke D., Reichenberger M. Double blind, randomized in vivo investigations comparing the antifungals clotrimazole, tolnaftate and naftifine (author's transl). Mykosen. 1980; 23(12): 657-68.
  14. Del Rosso J.Q., Kircik L.H. Optimizing topical antifungal therapy for superficial cutaneous fungal infections: focus on topical naftifine for cutaneous dermatophytosis. J Drugs Dermatol. 2013; 12(11): 165-71.
  15. Plaum S., Verma A., Fleischer A.B. Jr. et al. Detection and relevance of naftifine hydrochloride in the stratum corneum up to four weeks following the last application of naftifine cream and gel, 2%. J Drugs Dermatol. 2013; 12(9): 1004-8.
  16. Ghannoum M., Isham N., Verma A. et al. In vitro antifungal activity of naftifine hydrochloride against dermatophytes. Antimicrob Agents Chemother. 2013; 57(9): 4369-72.
  17. Rotta I., Ziegelmann P.K., Otuki M.F. et al. Efficacy of topical antifungals in the treatment of dermatophytosis: a mixed-treatment comparison metaanalysis involving 14 treatments. JAMA Dermatol. 2013; 149(3): 341-9.
  18. Rotta I., Sanchez A., Goncalves P.R. et al. Efficacy and safety of topical antifungals in the treatment of dermatomycosis: a systematic review. Br J Dermatol. 2012; 166(5): 927-933.
  19. Crawford F., Hollis S. Topical treatments for fungal infections of the skin and nails of the foot. Cochrane Database Syst Rev. 2007; 3: CD001434.
  20. Smith E.B., Wiss K., Hanifin J.M. et al. Comparison of once- and twice-daily naftifine cream regimens with twice-daily clotrimazole in the treatment of tinea pedis. J Am Acad Dermatol. 1990 Jun; 22 (6 Pt 1): 1116-7.
  21. Meinicke K., Striegel C., Weidinger G. Treatment of dermatomycosis with naftifin. Therapeutic effectiveness following once and twice daily administration. Mykosen. 1984 Dec; 27(12): 608-14.
  22. Stein Gold L.F., Parish L.C., Vlahovic T. et al. Efficacy and safety of naftifine HCl Gel 2% in the treatment of interdigital and Moccasin type tinea pedis: pooled results from two multicenter, randomized, double-blind, vehicle-controlled trials. J Drugs Dermatol. 2013 Aug; 12(8): 911-8.
  23. Evans E.G., James I.G., Seaman R.A., Richardson M.D. Does naftifine have anti-inflammatory properties? A double-blind comparative study with 1% clotrimazole/1% hydrocortisone in clinically diagnosed fungal infection of the skin. Br J Dermatol. 1993 Oct; 129(4): 437-42.
  24. Smith E.B., Breneman D.L., Griffith R.F. et al. Double-blind comparison of naftifine cream and clotrimazole/betamethasone dipropionate cream in the treatment of tinea pedis. J Am Acad Dermatol. 1992 Jan; 26(1): 125-7.
  25. Nada M., Hanafi S., al-Omari H. et al. Naftifine versus miconazole/hydrocortisone in inflammatory dermatophyte infections. Int J Dermatol. 1994 Aug; 33(8): 570-2.1.
  26. Nolting S. Investigation of the antibacterial effect of the antifungal agent naftifine- «left versus right» clinical comparative study between naftifine and gentamycini in pyoderma. Mykosen 1987; 30 Suppl 1: 124-8.
  27. Nemchaninova О.В., HYPERLINK "http://eli-brary.ru/author_items.asp?authorid=407150" o "Список публикаций этого автора" Petrenko O.S., Borovitskaya O.N. Rational antimycotic therapy for mycoses of the foot in patients with metabolic syndrom. Russ J skin and sex transmitt dis 2005; 6: 58-60. [Лыкова С.Г., Немчанинова О.Б., Петренко О.С., Боровицкая О.Н. Рациональная антимикотическая терапия микозов стоп у пациентов с метаболическим синдромом. Рос журн кож и вен бол 2005; (6): 58-60.]
  28. Maraki S. Epidemiology of dermatophytoses in Crete, Greece between 2004 and 2010. G Ital Dermatol Venereol. 2012 Jun; 147(3): 315-9.
  29. Sergeev A.Yu., Ivanov O.L., Sergeev Yu.V. i dr. Issledovanie sovremennoy epidemiologii onikhomikoza. Vestn dermatol i venerol. 2002; 3: 31-35. [Сергеев А.Ю., Иванов О.Л., Сергеев Ю.В. и др. Исследование современной эпидемиологии онихомикоза. Вестн дерматол и венерол. 2002; 3: 31-35.]
  30. Kungurov N.V., Kokhan M.M., Potekha A.Iu., Shcherbakova N.V. Efficacy of therapy of fungal skin and nail diseases Сііп Dermatol and Venerol 2008; 2: 8-16. [Кунгуров Н.В., Кохан М.М., Потеха А.Ю., Щербакова Н.В. Эффективность терапии грибковых заболеваний кожи и ногтей Клин дерматол и венерол 2008; (2): 8-16.] Вестник дерматологии и венерологии Фармакотерапия в дерматовенерологии л 77
  31. Stein Gold L.F., Parish L.C., Vlahovic T. et al. Efficacy and safety of naftifine HCl Gel 2% in the treatment of interdigital and Moccasin type tinea pedis: pooled results from two multicenter, randomized, double-blind, vehicle-controlled trials. J Drugs Dermatol 2013; 12(8): 911-8.
  32. Parish L.C., Parish J.L., Routh H.B. et al. A randomized, double-blind, vehicle-controlled efficacy and safety study of naftifine 2% cream in the treatment of tinea pedis. J Drugs Dermatol 2011; 10(11): 1282-8.
  33. Parish L.C., Parish J.L., Routh H.B. et al. A doubleblind, randomized, vehicle-controlled study evaluating the efficacy and safety of naftifine 2% cream in tinea cruris. J Drugs Dermatol 2011; 10(10): 1142-7.
  34. Gupta A.K., Einarson T.R., Summerbell R.C., Shear N.H. An overview of topical antifungal therapy in dermatomycoses: a North American perspective. Drugs 1998; 55(5): 645-674.
  35. Gold M.H., Bridges T., Avakian E. et al. An open-label study of naftifine hydrochloride 1% gel in the treatment of tinea versicolor. Skinmed 2011; 9(5): 283-6.
  36. Leiste D., Braun W., Fegeler W. et al. A doubleblind clinical trial of fenticonazole (2%) spray versus naftifine (1%) spray in patients with cutaneous mycoses. Curr Med Res Opin 1989; 11(9): 567-5.
  37. Zaias N., Astorga E., Cordero C.N. et al. Naftifine cream in the treatment of cutaneous candidiasis. Cutis 1988 Sep; 42(3): 238-40].
  38. Alchorne M.M., Paschoalick R.C., Forjaz M.H. Comparative study of tioconazole and clotrimazole in the treatment of tinea versicolor. Clin Ther 1987; 9(4): 360-7.
  39. Albanese G., Giorgetti P., Santagostino L., Di Cintio R., Colombo M.D. Evaluation of the efficacy of a new antimycotic molecule for topical use: naftifine. G Ital Dermatol Venereol 1989 May; 124(5):
  40. Abdul Bari M.A. Comparison of superficial mycosis treatment using Butenafine and Bifonazole nitrate clinical efficacy. Glob J Health Sci 2012 Nov 11; 5(1): 150-4.
  41. Gold M.H., Bridges T., Avakian E.V. et al. An open-label pilot study of naftifine 1% gel in the treatment of seborrheic dermatitis of the scalp. J Drugs Dermatol 2012; 11(4): 514-8.
  42. Ghannoum M., Isham N., Verma A., Plaum S., Fleischer A. Jr, Hardas B. In vitro antifungal activity of naftifine hydrochloride against dermatophytes. Antimicrob Agents Chemother 2013 Sep; 57(9): 4369-72.

Supplementary files

Supplementary Files
Action
1. JATS XML

Copyright (c) 2014 Matushevskaya Y.V., Svirshchevskaya Y.V.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 60448 от 30.12.2014.


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies