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Acute inflammation phase proteins in cases of IgE-mediated and IgE-independent atopic dermatitis
- Authors: Burdina A.V.1, Zorina V.N.1, Korotkiy N.G.2, Shkolnikova T.V.1, Zorin N.A.1
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Affiliations:
- Novokuznetsk State Institute of Postgraduate Medicine
- Pirogov Russian National Research Medical University
- Issue: Vol 90, No 4 (2014)
- Pages: 35-39
- Section: SHORT COMMUNICATION
- Submitted: 24.08.2017
- Published: 24.08.2014
- URL: https://vestnikdv.ru/jour/article/view/49
- DOI: https://doi.org/10.25208/0042-4609-2014-90-4-35-39
- ID: 49
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Abstract
Goal. To determine the blood serum level of α2-macroglobulin (α2-MG), α1-antitrypsin (α1-AT), lactoferrin (LF) and albumin in patients with IgE-mediated and IgE-independent atopic dermatitis (AD). Materials and methods. The authors tested blood serum of 60 adult patients suffering from atopic dermatitis at the exacerbation stage (30 patients with IgE-mediated and 30 patients with IgE-independent atopic dermatitis) and 20 healthy donors in order to determine the level of these proteins by rocket immunoelectrophoresis, enzyme-linked immunosorbent assay and immunoturbidimetry methods. Major results. The albumin level is reliably reduced in case of IgE-mediated AD while the LF and α1-AT levels are increased, and concentrations of LF α1-AT and a2-MG are increased as compared to healthy people. There are differences between the level of LF, α2-MG and α1-AT. There was a statistically significant correlation between the LF levels and SCORAD score in both forms, and α2-MG and α1-AT only in case of IgE-independent AD. Conclusion. These results confirm the difference in the roles of these polyfunctional proteins in the pathogenesis of IgE-mediated and IgE-independent AD.
About the authors
A. V. Burdina
Novokuznetsk State Institute of Postgraduate Medicine
Author for correspondence.
Email: nastyaburdina@mail.ru
Россия
V. N. Zorina
Novokuznetsk State Institute of Postgraduate Medicine
Email: noemail@neicon.ru
Россия
N. G. Korotkiy
Pirogov Russian National Research Medical University
Email: noemail@neicon.ru
Россия
T. V. Shkolnikova
Novokuznetsk State Institute of Postgraduate Medicine
Email: noemail@neicon.ru
Россия
N. A. Zorin
Novokuznetsk State Institute of Postgraduate Medicine
Email: noemail@neicon.ru
Россия
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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).