TLR - possible molecular target for biologic psoriasis therapy


Cite item

Abstract

Target: studies of 2, 4, 9 types of TLR in the affected skin of patients with psoriasis with evaluation of morphometric indices. Маterial and methods. Immunohistochemical skin research at 15 patients, suffering from psoriasis (12 women and 18 men) in the age of 19-68 y.o. and at 10 healthy trial subjects. Results. The increased expression of TLR2 и TLR4 was revealed in the skin patients, suffering from psoriasis. Opinions. This fact enlarges considerably psoriasis pathogenesis perceptions and determines the new vector of research, forwarded to the search of the ethologic factor, as well as the optimization of existing methods of the systemic psoriasis therapy.

Full Text

Толл-подобные рецепторы - возможная молекулярная мишень для биологической терапии псориаза
×

About the authors

O R Katunina

A V Rezaykina

References

  1. Janeway C.A., Medzhitov R. Innate immune recognition. Annu Rev Immunol- 2002; 20: 197-216.
  2. Kopp E.B., Medzhitov R. The Toll-receptor family and control of innate immunity. Curr Opin Immunol 1999; 11: 1: 13-28.
  3. von Andrian U H., Mackay C.B. T-cell function and migration: two sides of the same coin. N Engl J Med 2000; 343: 1020-1034.
  4. Takeuchi O., Akira S. Pattern Recognition Receptors and Inflammation. Cell 2010; 140: 805-820.

Copyright (c) 2012 Katunina O.R., Rezaykina A.V.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies