Pathogenesis and treatment of acne at women’s hyperandrogenism syndrome



Cite item

Full Text

Abstract

Аспе is one of most spread people’s disease and is characterized by the piloseboceial complex affection. Acne pathogenesis is a multifactor one, and the hyperandrogenism favors the disease development. The article highlights the acne pathogenesis, discusses methods of the endocrinologic examination and treatment of women’s hyperandrogenism.

Full Text

Патогенез и лечение акне при синдроме гиперандрогении у женщин
×

About the authors

E E GRODNITSKAYA

M A KURTSER

References

  1. Downing D. T., Strauss J. S., Pochi P. E. Variability in the chemical composition of human skin surface lipids. J Invest Dermatol 1969; 53: 322-7.
  2. Leyden J.J. New understandigs of the pathogenesis of acne. J Am Acad Dermatol 1995; 32: 15-25.
  3. Thomas D. R. Psychosocial effects of acne. J Cutan Med Surg 2004; 8: (4): 3-5.
  4. Zouboulis C.C., Eady A., Philpott M., et al. What is the pathogenesis of acne? Exp Dermatol 2005; 14: (2): 143-52.
  5. Makrantonaki E., Ganceviciene R., Zouboulis C. An update on the role of the sebaceous gland in the pathogenesis of acne. Dermatoendocrinol 2011; 3: (1): 41-9.
  6. Ebede T.L., Arch E.L., Berson D. Hormonal treatment of acne in women. J Clin Aesthet Dermatol 2009; 2: (12): 16-22.
  7. Sansone G., Reisner R. M. Differential rates of conversion of testosterone to dihydrotestosterone in acne and in normal human skin--a possible pathogenic factor in acne. J Invest Dermatol 1971; 56: (5): 366-72.
  8. Giltay E. J., Gooren L. J. Effects of sex steroid deprivation/administration on hair growth and skin sebum production in transsexual males and females. J Clin Endocrinol Metab 2000; 85: (8): 2913-21.
  9. Pochi P. E., Strauss J. S. Sebaceous gland response in man to the administration of testosterone, delta-4-androstenedione, and dehydroisoandrosterone. J Invest Dermatol 1969; 52: (1): 32-6.
  10. Akamatsu H., Zouboulis C. C., Orfanos C. E. Control of human sebocyte proliferation in vitro by testosterone and 5-alpha-dihydrotestosterone is dependent on the localization of the sebaceous glands. J Invest Dermatol 1992; 99: (4): 509-11.
  11. Zouboulis C. C., Seltmann H., Neitzel H. et al. Establishment and characterization of an immortalized human sebaceous gland cell line (SZ95). J Invest Dermatol 1999; 113: (6):1011-20.
  12. Chen W., Yang C. C., Sheu H. M. et al. Expression of peroxisome proliferator-activated receptor and CCAAT/enhancer binding protein transcription factors in cultured human sebocytes. J Invest Dermatol 2003; 121: (3): 441-7.
  13. Rosenfield R. L., Deplewski D., Kentsis A. et al. Mechanisms of androgen induction of sebocyte differentiation. Dermatology 1998; 196(1): 43-6.
  14. Makrantonaki E., Zouboulis C. C. Testosterone metabolism to 5alpha-dihydrotestosterone and synthesis of sebaceous lipids is regulated by the peroxisome proliferator-activated receptor ligand linoleic acid in human sebocytes. Br J Dermatol 2007; 156: (3): 428-32.
  15. Strauss J. S., Krowchuk D. P., Leyden J.J. et al. American Academy of Dermatology/American Academy of Dermatology Association. Guidelines of care for acne vulgaris management. J Am Acad Dermatol 2007; 56: (4): 651-63.
  16. Vermeulen A., Verdonck L., Kaufman J. M. A Critical Evaluation of Simple Methods for the Estimation of Free Testosterone in Serum J Clin Endocrinol Metab 1999; 84: 3666-3672.
  17. Arowojolu A. O., Gallo M. F., Lopez L. M. et al. Combined oral contraceptive pills for treatment of acne. Cochrane Database Syst Rev 2009; (3): CD004425.
  18. Palep-Singh M., Mook K., Barth J. et al. An observational study of Yasmin in the management of women with polycystic ovary syndrome. J Fam Plann Reprod Health Care 2004; 30: (3): 163-5.
  19. Carmina E., Lobo R.A. A comparison of the relative efficacy of antiandrogens for the treatment of acne in hyperandrogenic women. Clin Endocrinol (Oxf) 2002; 57: (2): 231-4.
  20. Brown J., Farquhar C., Lee O. et al. Spironolactone versus placebo or in combination with steroids for hirsutism and/or acne. Cochrane Database Syst Rev 2009; (2): CD000194.
  21. Волкова Е. Н., Есимбиева М. Л., Ландышева К. А. et al. Инновация ведения больных с акне: предварительные результаты лечения. Клин дерматол и венерол 2011; (1): 59-63.
  22. Goodfield M. J., Cox N. H., Bowser A. et al. Advice on the safe introduction and continued use of isotretinoin in acne in the U.K. 2010. Br J Dermatol 2010; 162: 1172-9.
  23. Nast A., Dreno B., Bettoli Vet al. European evidence-based (S3) guidelines for the treatment of acne. J Eur Acad Dermatol Venereol 2012; 26: (1): 1-29.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2012 GRODNITSKAYA E.E., KURTSER M.A.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 60448 от 30.12.2014.