Current approaches to diagnostics of mycosis fungoides
- Authors: Brattseva EV1, Rotanov SV1, Bratseva EV1, Rotanov SV1
-
Affiliations:
- Issue: Vol 86, No 6 (2010)
- Pages: 16-22
- Section: Articles
- Submitted: 11.03.2020
- Published: 15.12.2010
- URL: https://vestnikdv.ru/jour/article/view/773
- DOI: https://doi.org/10.25208/vdv773
- ID: 773
Cite item
Full Text
Abstract
The authors describe strong and weak sides of current methods for diagnostics of mycosis fungoides.
Diagnostics of mycosis fungoides is mainly based on the clinical presentation of this disease, which is a significant problem for
a dermatovenerologist, especially at early stages of the disease when rashes are of different types. Laboratory methods used to
confirm the diagnosis are microscopic examination and immunophenotypic analysis of skin biopsy samples from the affected
region as well as determination of clonality of T-lymphocytes in the skin using the PCR method.
Diagnostics of mycosis fungoides is mainly based on the clinical presentation of this disease, which is a significant problem for
a dermatovenerologist, especially at early stages of the disease when rashes are of different types. Laboratory methods used to
confirm the diagnosis are microscopic examination and immunophenotypic analysis of skin biopsy samples from the affected
region as well as determination of clonality of T-lymphocytes in the skin using the PCR method.
References
- Willemze R., Jaffe E.S., Burg G. et al. WHO-EORTC classification for cutaneous lymphomas. Blood 2005; 105: 3768-3785.
- Kim Y.H., Liu H.L., Mraz-Gernhard S. et al. Long-term outcome of 525 patients with mycosis fungoides and Sezary syndrome: clinical prognostic factors and risk for disease progression. Arch Dermatol 2003; 139: 857-866.
- Criscione V.D., Weinstock M.A. Incidence of cutaneous T-cell lymphoma in the United States, 1973-2002. Arch Dermatol 2007; 143: 854-859.
- Vakeva L., Pukkala E., Ranki A. Increased risk of secondary cancers in patients with primary cutaneous T cell lymphoma. J Invest Dermatol 2000; 115: 62-65.
- Лезвинская Е.М., Молочков В.А., Ларина Н.К. Заболеваемость злокачественными лимфомами кожи в Московской области и пути совершенствования лечебно-диагностической помощи больным. Росс. журн. кожн. и венерич. болезней. 2000; 4: 12-17.
- Tsianakas A., Kienast A.K., Hoeger P.H. Infantile-onset cutaneous T-cell lymphoma. Br J Dermatol 2008; 159: 1338-1341.
- Jackow C.M., McHam J.B., Friss A. et al. HLA-DR5 and DQB1*03 class II alleles are associ-ated with cutaneous T-cell lymphoma. J Invest Dermatol 1996; 107: 373-376.
- Lenane P., Powell F.C., O'Keane C. et al. Mycosis fungoides-a review of the management of 28 patients and of the recent literature. Int J Dermatol 2007; 46: 19-26.
- Pimpinelli N., Olsen E.A., Santucci M. et al. Defining early mycosis fungoides. J Am Acad Dermatol 2005; 53: 1053-1063.
- Whittaker S.J., Marsden J.R., Spittle M. et al. Joint British Association of Dermatologists and U.K. Cutaneous Lymphoma Group guidelines for the management of primary cutaneous T-cell lymphomas. Br J Dermatol 2003; 149: 1095-1107.
- Keehn C.A., Belongie I.P., Shistik G. et al. The diagnosis, staging, and treatment options for mycosis fungoides. Cancer Control 2007; 14: 102-111.
- Zackheim H.S., McCalmont T.H. Mycosis fungoides: the great imitator. J Am Acad Dermatol 2002; 47: 914-918.
- Rosen S.T., Querfeld C. Primary cutaneous T-cell lymphomas. Hematology Am Soc Hematol Educ Program 2006: 323-330, 513.
- Vergier B., de Muret A., Beylot-Barry M. et al. Transformation of mycosis fungoides: clinicopa-thological and prognostic features of 45 cases. French Study Group of Cutaneious Lymphomas. Blood 2000; 95: 2212-2218.
- Fraser-Andrews E.A., Woolford A.J., Russell-Jones R. et al. Detection of a peripheral blood T cell clone is an independent prognostic marker in mycosis fungoides. J Invest Dermatol 2000; 114: 117-121.
- Muche J.M., Lukowsky A., Asadullah K. et al. Demonstration of frequent occurrence of clonal T cells in the peripheral blood of patients with primary cutaneous T-cell lymphoma. Blood 1997; 90: 1636-1642.
- Vonderheid E.C., Diamond L.W., Lai S.M. et al. Lymph node histopathologic findings in cuta-neous T-cell lymphoma. A prognostic classification system based on morphologic assessment. Am J Clin Pathol 1992; 97: 121-129.
- Kim E.J., Lin J., Junkins-Hopkins J.M., Vittorio C.C., Rook A.H. Mycosis fungoides and sezary syndrome: an update. Curr Oncol Rep 2006; 8: 376-386.
- Willemze R., Meijer C.J. Classification of cutaneous T-cell lymphoma: from Alibert to WHO-EORTC.J Cutan Pathol 2006; 33 (Suppl 1): 18-26.
- Saada D., Lami M.C., Vabres P. et al. Mycosis fungoides presenting as annular erythema. Ann Dermatol Venereol 2005; 132: 35-37.
- Speron S., Gamelli R. Toxic epidermal necrolysis syndrome versus mycosis fungoides. J Burn Care Rehabil 1997; 18: 421-423.
- Gantcheva M., Lalova A., Broshtilova V. et al. Vesicular mycosis fungoides. J Dtsch Dermatol Ges 2005; 3: 898-900.
- Heliot I., Beylot-Barry M., Vergier B. et al. Cutaneous T-cell lymphoma bullosa: 2 cases. Ann Dermatol Venereol 2003; 130: 639-642.
- Spieth K., Grundmann-Kollmann M., Runne U. et al. Mycosisfungoides- type cutaneous T cell lymphoma of the hands and soles: a variant causing delay in diagnosis and adequate treatment of patients with palmoplantar eczema. Dermatology 2002; 205: 239-244.
- Kim S.T., Jeon Y.S., Sim H.J. et al. Clinicopathologic features and T-cell receptor gene rear-rangement findings of mycosis fungoides palmaris et plantaris. J Am Acad Dermatol 2006; 54: 466-471.
- Yoo S.S., Viglione M., Moresi M., Vonderheid E. Unilesional mycosis fungoides mimicking Bowen's disease. J Dermatol 2003; 30: 417-419.
- Liotta E.A., Turiansky G.W., Berberian B.J. et al. Unusual presentation of secondary syphilis in 2 HIV-1 positive patients. Cutis 2000; 66: 383-386, 389.
- Crum N.F. Disseminated coccidioidomycosis with cutaneous lesions clinically mimicking my-cosis fungoides. Int J Dermatol 2005; 44: 958-960.
- Choi T.S., Doh K.S., Kim S.H. et al. Clinicopathological and genotypic aspects of anticonvul-sant-induced pseudolymphoma syndrome. Br J Dermatol 2003; 148: 730-736.
- Кубанова А.А. (ред.) Клинические рекомендации. Дерматовенерология. М.: ДЭКС-Пресс, 2007.
- Guitart J., Kennedy J., Ronan S. et al. Histologic criteria for the diagnosis of mycosis fungoides: proposal for a grading system to standardize pathology reporting. J Cutan Pathol 2001; 28: 174-183.
- Smoller B.R., Detwiler S.P., Kohler S. et al. Role of histology in providing prognostic informa-tion in mycosis fungoides. J Cutan Pathol 1998; 25: 311-315.
- Santucci M., Biggeri A., Feller A.C. et al. Efficacy of histologic criteria for diagnosing early mycosis fungoides: an EORTC cutaneous lymphoma study group investigation. European Organization for Research and Treatment of Cancer. Am J Surg Pathol 2000; 24: 40-50.
- El-Darouti M.A., Marzouk S.A., Bosseila M. et al. Microscopic study of normal skin in cases of mycosis fungoides. Int J Dermatol 2006; 45: 1043-1046.
- Burg G., Kempf W. Cutaneous Lymphomas (Basic and Clinical Dermatology) Informa Health-care 2005; 592.
- Goeldel A.L., Cornillet-Lefebvre P., Durlach A. et al. T-cell receptor gamma gene rearrange-ment in cutaneous T-cell lymphoma: comparative study of polymerase chain reaction with denaturing gradi-ent gel electrophoresis and GeneScan analysis. Br J Dermatol 2009; 10 (http://www.wiley.com).
- Bergman R., Faclieru D., Sahar D. et al. Immunophenotyping and T-cell receptor gamma gene rearrangement analysis as an adjunct to the histopathologic diagnosis of mycosis fungoides. J Am Acad Dermatol 1998; 39: 554-559.
- Ormsby A., Bergfeld W.F., Tubbs R.R., Hsi E.D. Evaluation of a new paraffin-reactive CD7 T-cell deletion marker and a polymerase chain reaction-based T-cell receptor gene rearrangement assay: implications for diagnosis of mycosis fungoides in community clinical practice. J Am Acad Dermatol 2001; 45: 405-413.
- Smoller B.R., Santucci M., Wood G.S., et al. Histopathology and genetics of cutaneous T-cell lymphoma. Hematol Oncol Clin North Am 2003; 17: 1277-1311.
- Bernier C., Nguyen J.M., Quereux G. et al. CD13 and TCR clone: markers of early mycosis fungoides. Acta Derm Venereol 2007; 87: 155-159.
- Scala E., Narducci M.G., Amerio P. et al. T cell receptor-Vbeta analysis identifies a dominant CD60+ CD26- CD49d- T cell clone in the peripheral blood of Sezary syndrome patients. J Invest Dermatol 2002; 119: 193-196.
- Yoon J.S., Newton S.M., Wysocka M. et al. IL-21 enhances antitumor responses without stimu-lating proliferation of malignant T cells of patients with Sezary syndrome. J Invest Dermatol 2008; 128: 473-480.
- Novelli M., Comessati A., Quaglino P. et al. CD26 expression on cutaneous infiltrates from pa-tients with cutaneous T-cell lymphoma (CTCL) CD26 in cutaneous T-cell lymphoma patients. Adv Exp Med Biol 2003; 524: 223-234.
- Dummer R., Kamarashev J., Kempf W. et al. Junctional CD8+ cutaneous lymphomas with nonaggressive clinical behavior: a CD8+ variant of mycosis fungoides? Arch Dermatol 2002; 138: 199-203.
- Curco N., Servitje O., Llucia M. et al. Genotypic analysis of cutaneous T-cell lymphoma: a comparative study of Southern blot analysis with polymerase chain reaction amplification of the T-cell receptor- gamma gene. Br J Dermatol 1997; 137: 673-679.
- Khan N., Shariff N., Cobbold M. et al. Cytomegalovirus seropositivity drives the CD8 T cell repertoire toward greater clonality in healthy elderly individuals. J Immunol 2002; 169: 1984-1992.
- Jones D., Duvic M. The current state and future of clonality studies in mycosis fungoides. J In-vest Dermatol 2003; 121: ix-x.
- Dereure O., Balavoine M., Salles M.T. et al. Correlations between clinical, histologic, blood, and skin polymerase chain reaction outcome in patients treated for mycosis fungoides. J Invest Dermatol 2003; 121: 614-617.
- Delfau-Larue M.H., Dalac S., Lepage E. et al. Prognostic significance of a polymerase chain re-action-detectable dominant T-lymphocyte clone in cutaneous lesions of patients with mycosis fungoides. Blood 1998; 92: 3376-3380.
- Poszepczynska-Guigne E., Bagot M., Wechsler J. et al. Minimal residual disease in mycosis fungoides follow-up can be assessed by polymerase chain reaction. Br J Dermatol 2003; 148: 265-271.
- Vega F., Luthra R., Medeiros L.J. et al. Clonal heterogeneity in mycosis fungoides and its rela-tionship to clinical course. Blood 2002; 100: 3369-3373.
- Assaf C., Hummel M., Dippel E. et al. High detection rate of T-cell receptor beta chain rear-rangements in T-cell lymphoproliferations by family specific polymerase chain reaction in combination with the GeneScan technique and DNA sequencing. Blood 2000; 96: 640-646.
- Fink-Puches R., Wolf P., Kerl H., Cerroni L. Lichen aureus: clinicopathologic features, natural history, and relationship to mycosis fungoides. Arch Dermatol 2008; 144: 1169-1173.
- Hanna S., Walsh N., D'Intino Y., Langley R.G. Mycosis fungoides presenting as pigmented pur-puric dermatitis. Pediatr Dermatol 2006; 23: 350-354.
- Kandolf Sekulovic L., Cikota B., Stojadinovic O. et al. TCRgamma gene rearrangement analysis in skin samples and peripheral blood of mycosis fungoides patients. Acta Dermatovenerol Alp Panonica Adriat 2007; 16: 149-155.
- Cerroni L A.E., Ardigò M, Pütz B, Kerl H. Monoclonality of intraepidermal T lymphocytes in early mycosis fungoides detected by molecular analysis after laser-beam-based microdissection. J Invest Dermatol 2000; 114: 1154-1157.
- Delfau-Larue MH L.L., Wechsler J, Lepage E et al. Diagnostic value of dominant T-cell clones in peripheral blood in 363 patients presenting consecutively with a clinical suspicion of cutaneous lymphoma. Blood 2000; 96: 2987-2992.