Molecular Markers In Forecasting The Clinical Efficacy Of Infliximab In Psoriasis Patients



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Abstract

Biosamples (skin tissue samples taken from affection foci and blood serum) from 22 patients suffering from severe to medium psoriasis (8 women and 14 men) aged 19-57 treated with Infliximab were analyzed. As for skin tissue samples, the molecular structure of genes TNF-a, TNF-R-I and TNF-R-II, contents of cytokine TNF-a and its soluble receptors (sTNF-RI and sTNF-RII) and proteome composition was analyzed in skin tissue samples; contents of TNF-a, IL2, IL4, IL6, IL-8 and IL-10 were analyzed in the blood serum. The homozygous TT genotype of TNF-R-II gene at the 676 locus and high IL10 level in the blood serum (>2.7 pg/ml) was associated with the high intensity of the psoriasis patient response to treatment with Infliximab; the homozygous GG genotype of TNF-R-II gene at the 676 locus and low level of IL10 in the blood serum (<1.0 pg/ml) was associated with a weak response or no response to treatment with Infliximab. These results laid the basis for developing a method to forecast the treatment efficacy in psoriasis patients based on a genetically engineered biological drug - Infliximab.
Pilot results indicating a possible mutual relation between the composition of the skin proteome and psoriasis patient's therapeutic response to treatment with Infliximab have been obtained.

References

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