Efficient application of external softening and moisturizingdrugs for the treatment of atopic dermatitis in children



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Abstract

The article presents data confirming the efficacy of external application of Locobase Repair cream and Atoderm cream in a combination
with hydrocortisone 17-butyrate 0.1% (Locoid ointment) in children aged from 6 months to 12 years suffering from moderate
atopic dermatitis. The patients were followed up for a year. The treatment efficacy was estimated according to the dynamics of
the SCORAD index and skin instrumental examination indices (corneometry, tewametry and pH-metry). The life quality in children
younger than 5 years was estimated based on the Childrens Dermatology Life Quality Index (CDLQI). The external therapy mentioned
above resulted in the decreased frequency of atopic dermatitis exacerbations, their reduced severity, increased duration of
inter-recurrent periods and reduced need in topical corticosteroids.

References

  1. Кубанова А.А. Анализ эпидемиологической ситуации по заболеваемости инфекциями, передаваемыми половым путем, болезнями кожи и подкожной клетчатки населения Российской Федерации, по данным официальной государственной статистики. Вестн. дерматол. и венерол. 2008; № 5, 8-18.
  2. Балаболкин И.И. Современная концепция патогенеза и терапии атопического дерматита у детей. Современные проблемы аллергологии, клинической иммунологии и иммунофармакологии. М., 1998; 113-119.
  3. Хаитов Р.М., Кубанова А.А. Атопический дерматит: рекомендации для практических врачей. Российский национальный согласительный документ по атопическому дерматиту. М.: Фармарус Принт, 2002; 192 с.
  4. Смолкин Ю.С., Чебуркин А.А., Ревякина В.А. Механизмы развития атопического дерматита у детей: Обзор литературы. Рос. вестн. перинатол. и педиат. 2000; 45: 3: 25-29.
  5. Делягин В.М., Румянцев А.Г. Атопический дерматит у детей. Современные концепции патогенеза и терапии: Руководство для практических врачей. М., 2004; 437 с.
  6. Ellis C., Luger T. International Consensus Conference on Atopic Dermatitis II (ICCAD II) Clinical update and current treatment strategie. Br J Dermatol. 2003; 48: 3-10.
  7. Schultz-Larsen F., Hanifin J.M. Epidemiology of atopic dermatitis. Immunol Allergy Clin North Am 2002; 22: 1-24.
  8. Ring J., Przybilla B., Ruzicka T., eds. Handbook of Atopic Eczema, 2nd edn., Springer, Heidelberg, 2006.
  9. Торопова Н.П. Патогенетические основы и ключевые принципы наружной терапии при атопическом дерматите у детей. Вопр. соврем. педиат. 2002; 1: 6: 80-83.
  10. Хаитов Р.М., Кубанова А.А. Атопический дерматит: наружная терапия. Иллюстрированный атлас. М., 2002; 72.
  11. Hiscott J., Pestka S. Cytokine and growth factor: Reviews. Amsterdam: Elsevier 2007; 545.
  12. Leung D.Y. Atopic dermatitis: the skin as a window into the pathogenesis of chronic allergic diseases. J Allergy Clin Immunol 1995; 96: 3: 302-318.
  13. Leung D. Atopic dermatitis - An Update for the Next Millennium. J Allergy Clin Immunol 1999; 104: 132-135.
  14. Leung D.Y., Jane N., Leo L. New concepts in the pathogenesis of atopic dermatitis. Curr Opin Immunol 2003; 15: 634-638.
  15. Akdis C., Akdis M., Bieber T. et al. Diagnosis and treatment of atopic dermatitis in children and adults: European Academy of Allergology and Clinical Immunology/American Academy of Allergy, Asthma and Immunology/PRACTALL Consensus Report. J Allergy Clin Immunol 2006; 118: 152-169.
  16. Elias P. Stratum corneum defensive functions: an integrated view. J Invest Dermatol 2005; 125: 183-200.
  17. Imokawa G., Abe A., Yin K. et al. Decreased level of ceramides in stratun corneum of atopic dermatitis: an etiologic factor in atopic dry skin? Ibid 1991; 96: 523-526.
  18. Nassif A., Chan S., Storrs G., Hanifin J. Abnormal skin irritancy in atopic dermatitis and in atopy without dermatitis. Arch Dermatol 1994; 130: 1402-1407.
  19. Di Nardo A., Werlz P., Giannetti A., Seidenari S. Ceramide and cholesterol composition of the skin of patients with atopic dermatitis. Acta Derm Venerol 1998; 78: 27-30.
  20. Aalto-Korte K., Turpeinen M. Transepidermal water loss predicts systemic absorption of topical hydrocortisone in atopic dermatitis. Br J Dermatol 1996; 135: 497-498.
  21. Hanifin J., Hebert A., Mays S. Effects of a low-potency corticosteroid lotion plus a moisturizing regimen in the treatment of atopic dermatitis. Curr Ther Res 1998; 59: 227-233.
  22. Lucky A., Leach A., Laskarzewski P., Wenck H. Use of an emmolient as a steroid-sparing agent in the treatment of mild to moderate atopic dermatitis in children. Pediatr Dermatol 1997; 14: 321-324.
  23. Long C., Mills C., Finlay A. A practical guide to topical therapy in children. Br J Dermatol 1998; 138: 293-296.
  24. Chamlin S.L., Kao J., Freiden I.J. et al. Ceramide-dominant barrier repair lipids alleviate childhood atopic dermatitis: changes in barrier function provide a sensitive indicator of disease activity. J Am Acad Dermatol 2002; 47: 198-208.
  25. Wood L.C., Elias P.M., Calhoun C. et al. Barrier disruption stimulates interleukin-1 alpha expression and release from a preformed pool in murine epidermis. J Invest Dermatol 1996; 106: 397-403.
  26. Taieb A. Hypothesis: from epidermal barrier dysfunction to atopic disorders. Contact Dermatitis 1999; 41: 177-80.
  27. Palmer C.N., Irvine A.D., Terron-Kwiatkowski A. et al. Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis. Nat Genet 2006; 38: 441-6.
  28. Cork M.J., Robinson D.A., Vasilopoulos Y. et al. New perspectives on epidermal barrier dysfunction in atopic dermatitis: gene-environment interactions. J Allergy Clin Immunol 2006; 118: 3-21.
  29. Sator P., Schmidt J., Honigsmann H. et al. Comparison of epidermal hydration and skin surface lipids in healthy individuals and in patients with atopic dermatitis. Am Acad Dermatol 2003; 48: 352-358.
  30. Johansson S.G.O., Bieber T., Dahl R., et al. Revised nomenclature for allergy for global use: Report of the Nomenclature Review Committee of the World Allergy Organization, October 2003. J Allergy Clin Immunol 2004; 113: 832-836.

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Copyright (c) 2010 Proshutinskaya D.V., Tekucheva L.V., Proshutinskaya D.V., Tekucheva L.V.

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