Administering hepatoprotectors for psoriasis: a comparative clinical, laboratory and ultrasonic assessment of its efficacy

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There was a comparative study of the clinical efficacy of Heptral® and Essentiale® Forte N in 60 patients suffering from psoriasis. Such indices as psoriatic process severity, quality of life, ultrasonic criteria of psoriasis-mediated skin affection and hepatic function biochemistry were assessed. As a result of the treatment with the use of Heptral®, a distinct and statistically reliable reduction of the psoriasis severity, improvement in the quality of life and normalization of hepatic biochemistry indices were observed. In addition, a reduction in the thickness of epidermis and derma, increase in the ultrasonic density of the latter and more even distribution of the echo signal in all derma layers were recorded in the group taking Heptral® as compared to the group of patients receiving Essentiale® Forte N and control group.

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  1. Перламутров Ю.Н. Псориаз и современные методы его лечения/ Ю.Н.Перламутров, А.М.Соловьев // Лечащий врач. 2004. № 5. С. 38-43.
  2. Lench N., Iles M.M., Mackay I., Patel R., Sagoo G.S., Ward S.J., Dechairo B., Olavesen M., Carey A., Duff G.W., Cork M.J., TaziAhnini R. Single-point haplotype scores telomeric to human leukocyte antigen-C give a high susceptibility major histocompatability complex haplotype for psoriasis in a caucasian population// J. Invest. Dermatol. 2005, Mar. Vol. 124, № 3. P. 545-552.
  3. О вирусной этиологии псориаза / В.Ф. Корсун, А.В. Станевич, Н.З. Яговдик, М.М. Левин // Вестн. дерматол. и венерол. 1999. № 4. С. 9-11.
  4. Gelfand J.M., Feldman S.R., Stern R.S., Thomas J., Rolstad T., Margolis D.J. Determinants of quality of life in patients with psoriasis: a study from the US population // J. Am. Acad. Dermatol. 2004, Nov. Vol. 51, № 5. P. 704-708.
  5. Gudjonsson J.E., Johnston A., Sigmundsdottir H., Valdimarsson H. Immunopathogenic mechanisms in psoriasis // Clin. Exp. Immunol. 2004, Jan. Vol. 135, № 1. P. 1-8.
  6. Kastelan M., Massari L.P., Pasic A., Gruber F. New trends in the immunopathogenesis of psoriasis // Acta Dermatovenerol. Croat. 2004. Vol. 12, № 1. P. 26-29.
  7. Ortonne J.P. Redefining clinical response in psoriasis: targeting the pathological basis of disease // J. Drugs. Dermatol. 2004, Jan - Feb. Vol. 3, № 1. P. 13-20.
  8. Lindsay K., Gough A. Psoriatic arthritis, methotrexate and the liverare rheumatologists putting their patients at risk? // Rheumatology (Oxford). 2008, Jul. № 47(7). Р. 939-41.
  9. Miele L., Vallone S., Cefalo C., La Torre G., Di Stasi C., Vecchio F.M., D'Agostino M., Gabrieli M.L., Vero V., Biolato M., Pompili M., Gasbarrini G., Rapaccini G., Amerio P., De Simone C., Grieco A. Prevalence, characteristics and severity of non-alcoholic fatty liver disease in patients with chronic plaque psoriasis // J. Hepatol. 2009, Oct. № 51(4). Р. 778-86.
  10. Kreiss C., Amin S., Nalesnik M.A., Chopra K., Shakil A.O. Severe cholestatic hepatitis in a patient taking acitretin // Am. J. Gastroenterol. 2002, Mar. № 97(3). Р. 775-7.
  11. Roenigk H.H. Jr., Callen J.P., Guzzo C.A., Katz H.I., Lowe N., Madison K., Nigra T., Fiedler V.C., Armstrong R.B. Effects of ac-itretin on the liver // J. Am. Acad. Dermatol. 1999, Oct. № 41(4). Р. 584-8.
  12. Qi Cao, Ki M. Mark, Charles S. Lieber Dilinoleoylphosphatidylcholine decreases acetaldehyde-induced TNF-a generation in Kupffer cells of ethanol-fed rats // Biochem and Biophysic. Research. Communications. 2002. № 299. Р. 459-64.
  13. Qi Cao, Ki M. Mark, Charles S. Lieber DLPC decreases TGF-b1-induced collagen mRNA by inhibiting p38 MAPK in hepatic stellate cells // Am. J. Physicol. Gastrointest Liver Physiol. 2002. № 283. Р. 1051-61.
  14. Roenigk H.Jr. Skin manifestations of psoriasis. In: Roenigk H.Jr., Maibach H., eds.Psoriasis. 2nd Ed.New York: Marsel Dekker. 1991; 3.
  15. Котельникова А.Б., Фролова О.И., Раева Т.В., Ишутина Н.П. Клинико-метаболическая эффективность применения гептрала (адеметионина) у больных псориазом с патологией ге-патобилиарной системы / А.Б. Котельникова, О.И.Фролова, Т.В. Раева, Н.П. Ишутина // Вестн. дерматол. и венерол. 2009. № 5. С. 34-36.
  16. Neri S et. al. Role of Ademethionine (S-Adenosylmethionine) in Cyclosporin-Induced Cholestasis // Origional research article. P. 191-195.
  17. Корсунская И.М., Резникова М.М., Тогоева Л.Т., Аветикян С.С., Фаттехитдинова З.Г., Денисова Е.В., Егоренкова Е.В., Авакян В.Н. Центр теоретических проблем физико-химической фармакологии РАН, ГКБ № 14 им. В.Г. Короленко. / Новое в патогенетической терапии псориаза // Вестн. дерматол. и венерол. 2005. № 3. С. 20-24.

Copyright (c) 2010 BAKULEV A.L., KRAVCHENYA S.S.

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