Clinical, molecular and genetic studies of efficacy and safety of using UV irradiation for psoriasis patients

Abstract

The authors give the results of clinical, molecular and genetic studies of efficacy and safety of treatment of 87 patients suffering
from extensive psoriasis with the use of UV irradiation of different spectral ranges. They showed that the administration of a course
of treatment with the use of the PUVA therapy or narrowband medium-wave UV therapy with the wavelength of 311 nm does not
result in the development of any clinically significant genetic mutations associated with the DNA excision repair system. They
revealed that the GC genotype of the XPC gene in the 32828 site and CC genotype of the XPF gene in the 27945 site may
be predictors of a pronounced therapeutic effect in treatment of patients with the use of phototherapy methods. The authors
obtained data confirming a possible protective role of T>C polymorphism in the 27945 site of the XPF gene in the development of
phototoxic reactions when psoriasis patients undergo an UV therapy.

References

  1. Жилова М. Б., Каганова Н. Л., Фриго Н. В., Знаменская Л. Ф., Волков И. А., Волнухин В. А. Выбор генов, ассоциированных с эксцизионной системой репарации ДНК. Разработка про- токола исследования для изучения прогнозирования эффек- тивности и безопасности ультрафиолетовой терапии больных псориазом. Вестн. дерматол. и венерол. 2009; 6: 59-66.
  2. Сойфер В. Н. Репарация генетических повреждений. // Соро- сов. генетич. журн. 1997; 8: 4-13.
  3. Agar N. S., Halliday G. M., Barnetson R. S., Ananthaswamy H. N., Wheeler M., Jones A. M. The basal layer in human squamous tumors harbors more UVA than UVB fingerprint mutations: A role for UVA in human skin carcinogenesis. Proc Natl Acad Sci U S A 2004; 101: 14: 4954-9.
  4. Cleaver J. E. A. Summary of Mutations in the UV-Sensitive Disorders: Xeroderma Pigmentosum, Cockayne Syndrome, and Trichothiodystrophy / J. E. Cleaver, L. H. Thompson, A. S. Richardson, J. C. States. HUMAN MUTATION 1999; 14: 9-22.
  5. Diffey B. L., Farr P. M. The challenge of follow-up in narrowband ultraviolet B phototherapy. Br J Dermatol 2007; 157: 344-349.
  6. Hoeijmakers J. H.J Xeroderma pigmentosum group F caused by a defect in a structure-specific DNA repair endonuclease / J. H. J. Hoeijmakers, R. DWood. Cell 1996; 86: 811-822.
  7. Fredriksson T., Pettersson U. Severe psoriasis-oral therapy with a new retinoid. Dermatologica 1978; 157(4): 238-44.
  8. Lehmann A. R. The xeroderma pigmentosum group D (XPD) gene: one gene, two functions, three diseases / A. R. Lehmann. Genes Dev 2001; 15: 15-23.
  9. L. L. Characterization of molecular defects in Xeroderma pigmentosum group C / L. Li, E. S. Bales, C. A. Peterson, R. J. Legerski. Nat Genet 1993; 5: 413-417.
  10. Lindelof B., Sigurgeirsson B., Tegner E., Larko O., Johannesson A., Berne B. PUVA and cancer risk: the Swedish follow-up study. Br J Dermatol 1999; 141: 108-112.
  11. Ramos J., Villa J., Ruiz A., Armstrong R., Matta J. UV dose determines key characteristics of nonmelanoma skin cancer. Cancer Epidemiol. Biomarkers Prev 2004; 13: 2006-2011.
  12. Rigel D. S. Cutaneous ultraviolet exposure and its relationship to the development of skin cancer. J Am Acad Dermatol 2008; 58: 129-132.
  13. Sancar A. DNA repair in human. Ann Rev Genet 1995; 29: 69-105.
  14. Sijbers A. M. Xeroderma pigmentosum group F caused by a defect in a structure-specific DNA repair endonuclease / A. M. Sijbers, W. L. de Laat, R. R. Ariza, M. Biggerstaff, Y.-F. Wei, J. G. Moggs, K. C. Carter, B. K. Shell, E. Evans, M. C. de Jong, S. Rademakers, J. de Rooij, N. G. J. Jaspers, J. H. J. Hoeijmakers, R. D. Wood. Cell 1996; 86: 811-822.
  15. Slominski A., Pawelek J. Animals under the sun: Effects of UV radiation on mammalian skin. Clin Dermatol 1998; 16: 503-515.
  16. Stern R. S. The carcinogenic risk of treatments for severe psoriasis. / R. S. Stern, N. Laird. Cancer 1994; 73: 2759-2764.
  17. Stern R. S., Lunder E. J. Risk of squamous cell carcinoma and methoxsalen (Psoralen) and UV-A radiation (PUVA). A metaanalysis. Arch Dermatol 1998; 134: 1582-1585.
  18. Stern R. S. PUVA Follow up Study. The risk of melanoma in association with long-term exposure to PUVA. J Am Acad Dermatol 2001 May; 44(5): 755-761.

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Copyright (c) 2009 Zhilova M.B., Kubanov A.A., Lesnaya I.N., Frigo N.V., Volkov I.A., Znamenskaya L.F., Volnukhin V.A.

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