Clinical, molecular and genetic studies of efficacy and safety of using UV irradiation for psoriasis patients



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Abstract

The authors give the results of clinical, molecular and genetic studies of efficacy and safety of treatment of 87 patients suffering
from extensive psoriasis with the use of UV irradiation of different spectral ranges. They showed that the administration of a course
of treatment with the use of the PUVA therapy or narrowband medium-wave UV therapy with the wavelength of 311 nm does not
result in the development of any clinically significant genetic mutations associated with the DNA excision repair system. They
revealed that the GC genotype of the XPC gene in the 32828 site and CC genotype of the XPF gene in the 27945 site may
be predictors of a pronounced therapeutic effect in treatment of patients with the use of phototherapy methods. The authors
obtained data confirming a possible protective role of T>C polymorphism in the 27945 site of the XPF gene in the development of
phototoxic reactions when psoriasis patients undergo an UV therapy.

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Copyright (c) 2010 Zhilova M.B., Kubanov A.A., Lesnaya I.N., Frigo N.V., Volkov I.A., Znamenskaya L.F., Volnukhin V.A.

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