Skin barrier affection mechanisms and methods of their correction with the use of the Emolium series of cosmetic products



Cite item

Full Text

Abstract

The article generalizes the current concept of reasons and mechanisms of skin barrier affections, presents a method to correct such affections with the use of Emolium basic skin care products and provides results of the efficacy study of the Emolium cosmetic line along with the glucocorticosteroid therapy in patients suffering from atopic dermatitis.

References

  1. Дерматовенерология: учебник для студ. высш. мед. учеб. заведений / Е.В. Соколовский, Е.Р. Аравийская, К.Н. Монахов и др.; под ред. Е.В. Соколовского. М.: Издательский центр «Академия», 2005. 528 с.
  2. Nilesh Morar, William O.C.M. Cookson, John I. Harper and Miriam F. Moffatt. Filaggrin Mutations in Children with Severe Atopic Dermatitis. Journal of Investigative Dermatology (2007) 127, 1667-1672; doi: 10.1038/sj.jid.5700739; published online 15 February 2007.
  3. Белоусова Т.А., Горячкина М.В. Современные представления о структуре и функции кожного барьера и терапевтические возможности коррекции его нарушений // Рус. мед. журн., 2004. Т. 12, № 18. С. 1082-1084.
  4. Fartasch, M. The Epidermal Lamellar Body: A Fascinating Secretory Organelle Journal of Investigativ Dermatology Bibliographic details. 2004. Vol. 122, № 5. P. xi-xii.
  5. Florinda Maria Busi. Barrera epidermica en dermatitis atopica // Rev Asoc Col Dermatol. 2008 (Dee.).Vol. 16, № 4. P. 293, 301.
  6. Swartzendruber D.C., Wertz P.W., Kitko D.J. et al. Molecular models of the intercellular lipid lamellae in mammalian stratum corneum // J. Invest. Dermatol. 1989. Vol. 92. P. 251-257.
  7. Baran R., Maibach H.I. Textbook of cosmetic Dermatology / Martin Dunitz Ltd. 1998. C. 171-186, 203-224.
  8. Roitman E., Elias P.M. Human stratum corneum lipids: characterization and regional variations // J. Lipid. Res. 1983 Feb. Vol. 24, № 2. P. 120-30.
  9. Fulmer A.W., Kramer G.J. Stratum corneum lipid abnormalities in surfactant-induced dry scaly skin // J. Invest. Dermatol. 1986 May. Vol. 86, № 5. P. 598-602.
  10. Mao-Qiang M. et al. Exogenous non physiological vs physiological lipids: divergent mechanism for correction of permeability barrier dysfunctions // Arch Dermatol. 1995. Vol. 131. P. 809-876.
  11. Goldstein A.M., Abramovits W. Ceramides and the stratum corne- um: structure, function, and new methods to promote repair // Int. J. Dermatol. 2003. Vol. 42, № 4. P. 256-59.
  12. Swartzendruber D.C., Wertz P.W., Kitko D.J., Madison K.C., Downing D.T. Molecular models of the intercellular lipid lamellae in mammalian stratum corneum // J. Invest. Dermatol. 1989 Feb. Vol. 92, № 2. P. 251-7.
  13. Lampe M.A., Burlingame A.L., Whitney J., Williams ML, Brown BE, Roitman E, Elias PM. Human stratum corneum lipids: characterization and regional variations // J. Lipid. Res. 1983 Feb. Vol. 24, № 2. P. 120-30.
  14. Madison К.С. Barrier function of the skin: "la raison d'etre" of the epidermis // J. Invest. Dermatol. 2003. Vol. 121, № 2. P. 231-41.
  15. Sator P.G., Schmidt J.B., Honigsmann H. Comparison of epidermal hydration and skin surface lipids in healthy individuals and in patients with atopic dermatitis // J. Am. Acad. Dermatol. 2003. Vol. 48. P. 352-8.
  16. Arikawa J., Ishibashi M., Kawashima M., Takagi Y., Ichikawa Y., Imokawa G. Decreased levels of sphingosine, a natural antimicrobial agent, may be associated with vulnerability of the stratum corneum from patients with atopic dermatitis to colonization by Staphylococcus aureus // J. Invest. Dermatol. 2002. Vol. 119. P. 433-9.
  17. Руководство по дерматокосметологии / Под ред. Е.Р. Аравийской, Е.В. Соколовского. СПб.: ООО «Издательство Фолиант», 2008. 632 с.
  18. Fluhr J.W., Kao J., Jain M., et al. Generation of free fatty acids from phospholipids regulates stratum corneum acidification and integrity // J. Invest. Dermatol. 2001. Vol. 117, № 1. P. 44-51.
  19. Mao-Qiang M. et al. Fatty acids are required for epidermal permeability barrier function // J. Clin. Invest. 1993. Vol. 92. P. 791-798.
  20. Mao-Qiang M. et al. Exogenous non physiological vs physiological lipids: divergent mechanism for correction of permeability barrier dysfunctions // Arch. Dermatol. 1995. Vol. 131. P. 809-876.
  21. Coderch L., Lopez O., de la Maza A., Parra J.L. Ceramides and skin function // Am. J. Clin. Dermatol. 2003. Vol. 4, № 2. P. 107-29.
  22. Feingold K.R. et al. Cholesterol synthesis is required for cutaneous barrier function in mice // J. Clin. Invest. 1990. Vol. 86. P. 1783-1795.
  23. Wuthrich B. Definition and diagnosis of intrinsic versus extrinsic atopic dermatitis / In: Bieber TaL, DYM. Atopic dermatitis. Marcel Dekker, Inc. 2002. P. 1-20.
  24. Di Nardo A., Wertz P., Giannetti A. et al. Ceramide and cholesterol composition of the skin of patients with atopic dermatitis // Acta Derm. Venereol. 1998. Vol. 78, № 1. P. 27-30.
  25. Fluhr J.W., Elias P.M. Stratum corneum pH: formation and function of the 'acid mantle' // Exogenous Dermatology. 2002. Vol. 1, № 4. P. 163-75.
  26. Eberlein-Konig B., Schafer T., Huss-Marp J., et al. Skin surface pH, stratum corneum hydration, trans-epidermal water loss and skin roughness related to atopic eczema and skin dryness in a population of primary school children // Acta Derm. Venereol. 2000. Vol. 80, № 3. P. 188-91.
  27. Food allergy, dermatologic diseases, and anaphylaxis PRACTALL Consensus Report Diagnosis and treatment of atopic dermatitis in children and adults: European Academy of Allergology and Clinical Immunology / American Academy of Allergy, Asthma and Immunology / PRACTALL Consensus Report Cezmi A. Akdis, MD, a Mu E. beccel Akdis, MD, PhD, a Thomas Bieber, MD, PhD, b Carste 2006 American Academy of Allergy, Asthma and Immunology and the European Academy of Allergology and Clinical Immunology doi: 10.1016/j.jaci.2006.03.045n.
  28. Rippke F., Schreiner V., Doering T., Maibach H.I. Stratum corneum pH in atopic dermatitis: impact on skin barrier function and colonization with Staphylococcus aureus // Am. J. Clin. Dermatol. 2004. Vol. 5. P. 217-23.
  29. Vasilopoulos Y., Cork M.J., Murphy R., Williams H.C., Robinson D.A., Duff G.W. et al. Genetic association between an AACC insertion in the 39UTR of the stratum corneum chymotryptic enzyme gene and atopic dermatitis // J. Invest. Dermatol. 2004. Vol. 123. P. 62-6.
  30. Alan D. Irvine, McLean Breaking the (Un)Sound Barrier: Filaggrin Is a Major Gene for Atopic Dermatitis // J. Invest. Dermatol. 2006. Vol. 126. P. 1200-1202.
  31. Sandilands A., Terron-Kwiatkowski A., Hull P.R. et al.: Comprehensive analysis of the gene encoding filaggrin uncovers prevalent and rare mutations in ichthyosis vulgaris and atopic eczema // Nat. Genet. 2007. Vol. 39. P. 650-654.
  32. Hoffjan S.; S. Stemmler. On the Role of the Epidermal Differentiation Complex in Ichthyosis Vulgaris, Atopic Dermatitis and Psoriasis // Br. J. Dermatol. 2007. Vol. 157, № 3. P. 441-449.
  33. McGrath J.A.; Uitto J. The filaggrin story: novel insights into skin- barrier function and disease // Trends. Mol. Med. 2008. Vol. 14, № 1. P. 20-7.
  34. O'Regan G.M., Sandilands A., McLean W.H., Irvine A.D.: Filaggrin in atopic dermatitis // J. Allergy Clin. Immunol. 2008 (Epub ahead of print).
  35. Henderson J., Northstone K., Lee S. et al.: The burden of disease associated with filaggrin mutations: a population-based, longitudinal birth cohort study // J. Allergy Clin. Immunol. 2008. Vol. 121. P. 872-877.
  36. Weidinger S., O'Sullivan M., Illig T. et al.: Filaggrin mutations, atopic eczema, hay fever, and asthma in children // J. Allergy Clin. Immunol. 2008. Vol. 121. P. 1203-1209.
  37. Brown S., Irvine A. Atopic eczema and the filaggrin story // Semin. Cutan. Med. Surg. 2008. Vol. 27. P. 128-137.
  38. Stephan Weidinger, MD, Maureen O'Sullican, MD, Thomas Illig, PhD, Hansjцrg Baurecht, MSc, Martin Depner, MSc, Elke Rodriguez, MSc, Andreas Ruether, PhD, Norman Klopp, PhD, Christian Vogelberg, MD, Stephan K. Weiland, MD, WH Irwin McLean, PhD, DSc, FRSE, Erika von Mutius, MD, Alan D Irvine, MD, Michael Kabesch, MD. Scratching below the surface: Filaggrin mutations, atopic eczema, hay fever and asthma in children // JACI Highlights. May 2008
  39. Аравийская Е.Р., Соколовский Е.В. Сухость кожи. Причины и механизмы возникновения. Принципы коррекции // Журн. дерматол. и косметол. 2002. Т. 2. С. 10-13.
  40. Hanofin J.M., Tofte S.J. Update on therapy of atopic dermatitis // J. Allergy. Clin. Immunol. 1999. Vol. 104 (3 Pt 2). P. 123-125.
  41. Монахов К.Н., Холодилова Н.А. Применение препаратов «Эмолиум» при лечении больных атопическим дерматитом // Клин. дерматол. и венерол. 2009. Т. 5.
  42. Adrian M. Goldstein, MD, PhD, and William Abramovits, MD. Ceramides and the stratum corneum: structure, function, and new metods to promote repair // Int. J. Dermatol. 2003. Vol. 42. P. 256-259.
  43. Menon G.K., Feingold K.R., Moser A.H. et al. De novo sterol genesis in the skin. II. Regulation by coetaneous barrier requirements // J. Lipid. Res. 1985. Vol. 26. P. 418-427.
  44. Grubauer G., Elias P.M., Feingold K.R. Transepidermal water loss the signal for recovery of barrier strukture and function // J. Lipid. Res. 1989. Vol. 30. P. 323-333.
  45. Adamski Z., Kaszuba A., Placek W. Wieloosrodkowe badanie skutec- znosci preparatow emoliencyjnych z linii Emolium, informacja naukowa: Nepentes S.A. 2007.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2010 MONAKHOV K.N., DOMBROVSKAYA D.K.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 60448 от 30.12.2014.


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies