Studies on effectiveness and safety of system retinoids use in therapy ofadolescent acne

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The article describes up-to-date data on mechanics of epigenetic effects of system retinoid - isotretinoin (Roaccutane). It is
noted, that modern acne therapy is able not only to pathogenetically influence consequences of the process, but effect genetical
causes of desease, leading to persistant changes and normalization of regulatory segments DNA structure under influence of
isotretinoin. Also this article lists data on the use of isotretinoin (Roaccutane) for acne treatment of 237 adolescents. Studies were
performed on frequency of occurrence, degree of manifestation of secondary effects and methods of levereging this effects in
practical use. Authors state that correctly prescribed treatments are safe and do not cause serious secondary effects with in case
of long treatmetns.


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Copyright (c) 2010 Murashkin N.N., Ivanov A.M., Zaslavsky D.V., Kamilova T.A.

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