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Studies on effectiveness and safety of system retinoids use in therapy ofadolescent acne
- Authors: Murashkin NN1, Ivanov AM1, Zaslavsky DV1, Kamilova TA1
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Affiliations:
- Issue: Vol 86, No 5 (2010)
- Pages: 112-116
- Section: Articles
- URL: https://vestnikdv.ru/jour/article/view/983
- DOI: https://doi.org/10.25208/vdv983
- ID: 983
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Abstract
The article describes up-to-date data on mechanics of epigenetic effects of system retinoid - isotretinoin (Roaccutane). It is
noted, that modern acne therapy is able not only to pathogenetically influence consequences of the process, but effect genetical
causes of desease, leading to persistant changes and normalization of regulatory segments DNA structure under influence of
isotretinoin. Also this article lists data on the use of isotretinoin (Roaccutane) for acne treatment of 237 adolescents. Studies were
performed on frequency of occurrence, degree of manifestation of secondary effects and methods of levereging this effects in
practical use. Authors state that correctly prescribed treatments are safe and do not cause serious secondary effects with in case
of long treatmetns.
noted, that modern acne therapy is able not only to pathogenetically influence consequences of the process, but effect genetical
causes of desease, leading to persistant changes and normalization of regulatory segments DNA structure under influence of
isotretinoin. Also this article lists data on the use of isotretinoin (Roaccutane) for acne treatment of 237 adolescents. Studies were
performed on frequency of occurrence, degree of manifestation of secondary effects and methods of levereging this effects in
practical use. Authors state that correctly prescribed treatments are safe and do not cause serious secondary effects with in case
of long treatmetns.
Keywords
References
- Аравийская Е.А., Красносельских Т.В., Соколовский Е.В редактор. Кожный зуд. Акне. Урогенитальная хламидийная инфекция. СПб.: Сотис, 1998; 73-77.
- Самцов А.В. Акне и акнеформные дерматозы. М., 2009; 32-45.
- Эллинг Д. Секреты дерматологии. СПб., 1999: 513.
- Csoka A.B., Szyf M. Epigenetic side-effects of common pharmaceuticals: a potential new field in medicine and pharmacology. Med Hypotheses. 2009; 73(5): 770-80.
- Leyden J. A review of the use of combination therapies for the treatment of acne vulgaris. J Am Acad Dermatol. 2003; 49: 200-10.
- Kim J., et al. Eicosapentaenoic acid inhibits TNF-alpha-induced matrix metalloproteinase-9 expression in human keratinocytes HaCaT cells. Biochem Biophys Res Commun. 2008; 368: 343-9.
- Melnik B.C. et al. Anti-acne agents attenuate FGFR2 signal transduction in acne. J Invest Dermatol. 2009; 129(8): 1868-77.
- Nelson A.M. et al. Neutrophil gelatinase-associated lipocalin mediates 13-cis retinoic acid-induced apoptosis of human sebaceous gland cells. J Clin Invest. 2008; 118(4): 1468-1478.
- Rodondi N. et al. High risk for hyperlipidemia and the metabolic syndrome after an episode of hypertriglyceridemia during 13-cis retinoic acid therapy for acne: a pharmacogenetic study. Ann Intern Med. 2002; 136(8): 582-9.
- Yang Z. et al. Relationship between the CAG repeat polymorphism in the androgen receptor gene and acne in the Han ethnic group. Dermatology. 2009; 218(4): 302-6.
- Zaenglein A., Thiboutot D. Expert Committee Recommendations for Acne Management. Pediatrics. 2006; 118: 1188-99.
- Zitzmann M, Nieschlag E. The CAG repeat polymorphism within the androgen receptor gene and maleness. Int J Androl. 2003; 26: 76-83.
- Zouboulis C.C. Exploration of retinoid activity and the role of inflammation in acne: issues affecting future directions for acne therapy. J Eur Acad Dermatol Venereol. 2001; 15 Suppl 3: 63-7.
- Zouboulis C. C., Piquero-Martin J. Update and Future of Systemic Acne Treatment. Dermatology. 2003; 206: 37-53.
Supplementary files
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).