Vol 90, No 1 (2014)

EDITORIAL

How to stand up plagiarism in the scientific medical publications?

Oganov R.G., Kutishenko N.P., Anichkov D.A.

Abstract

Представляем вниманию читателей статью* о проблеме, актуальной не только для кардиологов, но и для всей медицинской общественности. Редакция журнала «Вестник дерматологии и венерологии» выражает надежду, что данная статья будет полезна читателям, авторам и рецензентам в реализации совместных усилий по выявлению и предотвращению плагиата.
Vestnik dermatologii i venerologii. 2014;90(1):14-16
pages 14-16 views

Application of Confocal Laser Scanning Microscopy in Biology and Medicine

Volkov I.A., Frigo N.V., Znamenskaya L.F., Katunina O.R.

Abstract

Fluorescence confocal laser scanning microscopy and reflectance confocal laser scanning microscopy are up-to-date highend study methods. Confocal microscopy is used in cell biology and medicine. By using confocal microscopy, it is possible to study bioplasts and localization of protein molecules and other compounds relative to cell or tissue structures, and to monitor dynamic cell processes. Confocal microscopes enable layer-by-layer scanning of test items to create demonstrable 3D models. As compared to usual fluorescent microscopes, confocal microscopes are characterized by a higher contrast ratio and image definition.
Vestnik dermatologii i venerologii. 2014;90(1):17-24
pages 17-24 views

Pyoderma gangrenosum: problems related to the diagnostics and treatment

Patrushev A.V., Samtsov A.V., Barbinov V.V., Sukharev A.V., Belousova I.E.

Abstract

The authors provide current data related to the etiology, pathogenesis, classification, clinical picture, differential diagnostics and treatment methods of pyoderma gangrenosum.
Vestnik dermatologii i venerologii. 2014;90(1):25-29
pages 25-29 views

GUIDELINES FOR PRACTITIONERS

Optimization of diagnostics and treatment of posttraumatic onycholysis

Neznakhina M.S., Petrova G.A., Garanina O.Y., Shlivko I.L., Ellinsky D.O., Petrova K.S.

Abstract

Onycholysis is a peculiar and prevalent nail affection conditioned by the detachment of the distal part of the nail from the nail bed. The absence of any reliable diagnostics criteria often results in diagnostics errors, inadequate treatment and reduced patient’s life quality. Goal of the research. To find out whether it is possible to use OCT for diagnosing onycholysis and Merz Spezial Dragees for the treatment of posttraumatic onycholysis, and to reasonably confirm the drug efficacy using OCT. Materials and methods. The study involved 15 volunteers with posttraumatic onycholysis aged 20-35 (mean age: 28) including 12 female and 3 male subjects. One nail was affected in 7 cases, and two nails were affected in 8 cases. The area of the onycholysis zone was less than one third of the nail area (mean NAPSI value: 2.9 points). For the purposes of clinical control over the efficacy of Merz Spezial Dragees and nail monitoring, the OCT method was applied. Tests were performed 5 and 7 weeks after the observation and treatment onset. Results. Merz Spezial Dragees contribute to faster regression of clinical manifestations of posttraumatic onycholysis and recovery of the normal state of the nail.
Vestnik dermatologii i venerologii. 2014;90(1):53-58
pages 53-58 views

Pyoderma gangrenosum. experience of successful treatment with systemic glucocorticosteroids, azathioprine, antibiotics and phototherapy using the «PhotoDyn-750» device

Teplyuk N.P., Belousova T.A., Paramonov A.A., Grabovskaya O.V.

Abstract

The article presents the results of a clinical observation of a rare dermatosis, pyoderma gangrenosum, and results of successful complex treatment of the disease with systemic GCS, azathioprine, antibiotics and phototherapy using the «PhotoDyn-750» device.
Vestnik dermatologii i venerologii. 2014;90(1):59-63
pages 59-63 views

New Aspects in Studies of Acne in Women

Samtsov A.V.

Abstract

The review generalizes and summarizes new information about epidemiology, pathogenesis, diagnostics and treatment of acne in women.
Vestnik dermatologii i venerologii. 2014;90(1):64-68
pages 64-68 views

Application of external drugs comprising silver compounds for the treatment of pyodermic patients

Samtsov A.V., Telichko I.N., Statsenko A.V., Khairutdinov V.R.

Abstract

An external anti-bacterial therapy is selected for pyodermic patients empirically. Silver sulfathiazole has an evident anti-inflammatory and anti-microbial effect against a broad range of microorganisms. Goal of the study. To assess the efficacy, safety and tolerability of a cream comprising 2% silver sulfathiazole vs. 3% tetracycline ointment for the treatment of pyodermic patients. Materials and methods. The study involved 50 pyodermic patients (at the mean age of 23.5 ± 4.1 years) including 31 (62%) male and 19 (38%) female patients. The patients were divided into two groups: Group I (n = 35) used the cream comprising 2% silver sulfathiazole while Group II (n = 15) was administered 3% tetracycline ointment. All of the patients were assessed for clinical and microbiological efficacy of the therapy. Results. The average patient recovery time in Group I amounted to 8.7 ± 0.9 days and 13.1 ± 2.7 days in Group II (р < 0.01). As many as 33 patients (94.3%) achieved clinical recovery and 2 patients (5.7%) achieved improvement by Day 10 in Group I; in Group II, clinical recovery was observed in 8 patients (53.3%), improvement - in 3 patients (20%), and no effect - in 4 patients (26.7%). Conclusion. The external anti-bacterial monotherapy of pyodermic patients with the cream comprising 2% silver sulfathiazole is more efficient than treatment with 3% tetracycline ointment. High clinical and microbiological efficacy of the cream comprising 2% silver sulfathiazole makes it possible to recommend it for empirical treatment of pyodermic patients.
Vestnik dermatologii i venerologii. 2014;90(1):75-80
pages 75-80 views

Long-term therapy of severe acne: selection of doses and administration schemes for systemic isotretinoin

Bakulev A.L., Kravchenya S.S., Platonova A.N., Igonina I.A.

Abstract

The article presents current data on the application of a systemic retinoid, isotretinoin, on the basis of the Lidose system for the treatment of patients with severe forms of acne. It also discusses issues of optimization of the daily dose of isotretinoin taking into consideration long-term clinical efficacy and safety of the therapy. The article presents the results of the authors’ study demonstrating the possibility to select mainly large or small doses of systemic isotretinoin depending on the treatment duration.
Vestnik dermatologii i venerologii. 2014;90(1):81-88
pages 81-88 views

Articles published in Vestnik Dermatologii i Venerologii in 2013

Article E.
Vestnik dermatologii i venerologii. 2014;90(1):89-91
pages 89-91 views

RULES FOR AUTHOR

Article E.
Vestnik dermatologii i venerologii. 2014;90(1):92-96
pages 92-96 views

Ulcerative form of pyoderma gangrenosum (a case study description)

Patrushev A.V., Samtsov A.V., Barbinov V.V., Sukharev A.V., Belousova I.E., S Chizhov A...

Abstract

The authors describe a case of pyoderma gangrenosum when the patient’s external therapy included Tecasorb disposable sterile tissue-based absorption wipes featuring activated carbon manufactured based on nanotechnologies. The authors describe and confirm that the following present-day study method can be used for diagnostics of the disease: mass spectrometry of microbial agents in biological environments.
Vestnik dermatologii i venerologii. 2014;90(1):69-74
pages 69-74 views

Level of the proliferative activity of lymphocytes in case of mycosis fungoides and plaque parapsoriasis

Zhukov A.S., Belousova I.E., Khairutdinov V.R., Telichko I.N., Samtsov A.V.

Abstract

The level of the proliferative activity is an important predictor of a number of oncologic diseases; at the same time, its diagnostic value for mycosis fungoides was not adequately investigated. Goal. To study the proliferative activity of lymphocytes in the skin of patients suffering form mycosis fungoides and plaque parapsoriasis. Materials and methods. The level of CD3+ and Ki-67+ cells was determined in skin biopsy samples taken from patients suffering from mycosis fungoides (18 subjects) and plaque parapsoriasis (6 subjects) by means of immunohistochemistry. The epidermal to dermal skin cell proliferative activity ratio (Ki-67+) and cell proliferative activity index were calculated. The control group comprised 16 healthy people. Results. The epidermal to dermal skin cell proliferative activity ratio amounted to 10.9 in healthy people, 5.43 in patients suffering from plaque parapsoriasis, and 3.84 and 2.42 in patients suffering from mycosis fungoides, spotty and plaque and tumor stages, respectively. The percentage of proliferative CD3+Ki-67+ cells relative to the total number of T-lymphocytes amounted to 1% in the patients suffering from plaque parapsoriasis and 3% in the patients with mycosis fungoides, spotty stage. Conclusion. The epidermal to dermal skin cell proliferative activity ratio (Ki-67+) in patients suffering from mycosis fungoides at any stage is lower than that in healthy subjects and patients suffering from parapsoriasis. The cell proliferative activity index was higher in the patients with mycosis fungoides, plaque and tumor stage, than in the patients with parapsoriasis. The number of CD3+Ki-67+ cells was higher in the patients with mycosis fungoides, spotty and plaque and tumor stages, than in the healthy subjects and patients suffering from parapsoriasis.
Vestnik dermatologii i venerologii. 2014;90(1):30-36
pages 30-36 views

Role of disorders related to idiotypic and anti-idiotypic interactions in slowing down the achievement of negative serologic reactions in patients with early onset forms of syphilis after specific therapy

Volkova Y.N., Morozov S.G., Mitichkina Y.V., Grigoriyeva A.A., Yelistratova I.V.

Abstract

Goal. To study the humoral immunity state in patients with the slowed down achievement of negative serologic reactions after the treatment of early onset forms of syphilis by means of examining the blood serum level of idiotypic and anti-idiotypic antibodies to cardiolipin and p17 Treponema Pallidum antigenic protein. Materials and methods. The study involved 324 patients (39.5% male and 60.5% female) with the slowed down achievement of negative serologic reactions. Primary (idiotypic) antibodies to cardiolipin and p17 protein were obtained using immunochromatographic assays with the help of the Bio Logik LP system. Purified antibodies were concentrated using the ultrafiltration technique with the aid of the XM-100А membrane. To obtain the rabbit antiserum to p17 Treponema Pallidum protein, chinchilla rabbits were immunized using the commercial recombinant p17 protein. To determine anti-cardiolipin idiotypic antibodies in the blood serum, the ELISa method optimized for detecting anti-cardiolipin antibodies was applied. To determine anti-cardiolipin anti-idiotypic antibodies as well as idiotypic and anti-idiotypic antibodies to p17 Treponema Pallidum protein, the standard ELISA method was applied. The following antigens were used to process the pads: F(ab)2 fragments of anti-cardiolipin antibodies (5 μg/mL), recombinant р17 T. pallidum protein (5 μg/mL) and F(ab)2 fragments of antibodies to р17 T. pallidum protein (10 μg/mL). The level of antibodies was assessed based on the absorbancy and expressed in conventional activity units using the K coefficient being the absorbancy of the serum under examination to the mean absorbancy of control serums ratio. The K value exceeding 1.5 conventional units indicated the increased level of antibodies. Results. Patients with the slowed down achievement of negative serologic reactions demonstrated a selective increase in the level of anti-idiotypic antibodies (AIAB) relative to T. pallidum antigens, cardiolipin and p17 protein, vs. first-order antibodies, which points at abnormal mutual regulation between idiotypic antibodies (IAB) and AIAB; the discovered phenomenon lays the immunochemical basis for the formation of a self-sustaining “vicious circle” contributing to the induction of high levels of antibodies to treponema antigens even when the pathogen was destroyed.
Vestnik dermatologii i venerologii. 2014;90(1):37-44
pages 37-44 views

Analysis of the long-term outcome of treatment of syphilitic patients with positive non-treponemal serology tests with the use of ceftriaxone

Katunin G.L., Rubcov A.B.

Abstract

Analysis of the long-term outcome of treatment of syphilitic patients with positive non-treponemal serology tests with the use of ceftriaxone
Vestnik dermatologii i venerologii. 2014;90(1):45-52
pages 45-52 views

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