Vol 93, No 2 (2017)

Programs of the preventive interventions against sexually transmitted infections in the high-risk subpopulations

Krasnoselskikh T.V., Sokolovskiy E.V.

Abstract

A review article highlights the practical issues of design, implementation and effectiveness estimation of STI prevention programs aimed to correct the behavior leading to infection. the importance of epidemiological modeling method for the organization of preventive interventions is discussed. the prospects of the multidisciplinary behavioral approach to STI prevention are demonstrated.
Vestnik dermatologii i venerologii. 2017;93(2):12-19
pages 12-19 views

Assessment of prognostic predictive value at the mycosis fungoides

Zhukov A.S., Telichko I.N., Belousova I.E., Samcov A.V.

Abstract

Micosis fungoides is a primary skin lymphoma characterized with indolent disease course and favorable prognosis. Опіу at some patients one can observe aggressive development of the disease to malignant stage with the exracutaneous outspread. the modern data about the prognostic factors are presented in the review. Disclosure of these factors allows to forecast the course of disease. there is given attention to integral estimation of survival rates on the ground of tNMB-staging sand estimation of the CUP-index. Definition of combination of different prognostic factors would allow to create prognostic models enabling to diagnose on the early stages of disease the patients with high risk of progression of mycosis fungoides.
Vestnik dermatologii i venerologii. 2017;93(2):20-26
pages 20-26 views

Associative link of clinical manifestations of the secondary syphilis of skin and mucosa with histocompatibility antigens Class I

Koshkin S.V., Chermnyh T.V., Zajceva G.A., Evseeva A.L., Ryabova V.V.

Abstract

Sixty patients with different clinical symptoms of secondary syphilis (ulcer chancres, pustular syphilis, hypertrophic papules, widespread leukoderma and alopecia) were examined in order to study the distribution pattern of histocompatibility antigens of the first class in patients with secondary syphilis of the skin and mucous membranes. As a result of the study, the presence of an associative relationship between the distribution pattern of histocompatibility antigens of the first class and various clinical manifestations in patients with secondary syphilis was established.
Vestnik dermatologii i venerologii. 2017;93(2):27-33
pages 27-33 views

Improvement of laboratory diagnostics of urogenital chlamydial infection in patients with impaired reproductive functions found to be infected with Chlamydia trachomatis

Fedorova V.A., Sultanakhmedov E.S., Saltykov Y.V., Utz S.R., Motin V.L.

Abstract

The dominant role in human infertility has been attributed to sexually transmitted infections (STIs) with a leading contribution of urogenital chlamydial infection (UGCI) caused by Chlamydia trachomatis (CT). the two variants of this pathogen are represented by the wild-type (wtCT) and new Swedish (nvCT) strains containing 377 bp deletion within the cryptic plasmid orf1 gene. Objective. The purpose of the study was investigation of the clinical specimens obtained from the urogenital tract of couples coping with infertility for the presence of genetic material of wtCT and nvCT. Material and methods. Clinical samples (scrapings from the urethra and cervix) obtained from 25 to 41 years old couples (n = 14) were tested for the presence of identifiable wtCT and nvCT chlamydia DNA by monoplex and duplex PCR, specific antigens C. trachomatis in elementary bodies by using immunofluorescence analysis (IFA), while detection of anti-chlamydia antibodies in sera was determined by immunoenzymatic assay (IEA). Results. The nvCT variant with typical deletion of 377 bp within the orf1 gene that belongs to the genovar e subtype E1 was detected in 100% of couples with infertility. The negative results of DNA testing for wtcT were registered in 87.5% of patients from this group, while one individual (12.5%) was likely coinfected with nvCT and wtCT of E1 and D genovars, respectively. The wtCT strains of genovar E (subtypes E1, E2, E6), g (subtypes G1, G2), F (subtypes F1), and K were identified in control group among patients with UGCI. The study revealed difficulties in detection of nvCT by nucleic acid amplification test (NAAT), IFA, and IEA; data on comparison of the efficacy of these methods are presented. Conclusion. Chronic UGCI in patients with reproductive dysfunctions can be caused by nvCT alone or as result of co-infection with nvCT and wtCT. The negative results in NAAT may not 100% correlate with the absence of UGCI that requires further confirmation in tests allowing detection of all known variants of C. trachomatis.
Vestnik dermatologii i venerologii. 2017;93(2):34-44
pages 34-44 views

GUIDELINES FOR PRACTITIONERS

Diagnosis of actinic keratosis by dermatoscopy

Khlebnikova A.N., Obydenova K.V., Sedova T.G., Andrukhina V.V.

Abstract

Introduction: Actinic keratosis (AK) is a local introepidermal atypia of keratinocytes, formed as a result of intense and prolonged exposure to sunlight. AK lesions located on exposed areas of skin, mostly on the face, in this regard, a more relevant non-invasive diagnostic techniques, primarily dermatoscopy. Material and methods: We examined 35 patients and revealed they have 204 hearth. Results: Of the 204 lesions erythematous form was found in 160 (78, 4%) cases, keratotic - 24 (11,8%), pigmental (9.8 %). Patients with AK most private dermatoscopic signs were erythema (90,2%), vascular structures (67,65%), keratin scales (51,47%), pseudonetwork (23,04%). Discussion: Analyzing dermoscopic picture of the most common forms of AK met the characteristics for each shape. A detailed study of vascular structures allows for the differential diagnosis of cancer in situ. While AK watched point and the glomerular vessels of not more than 10% of cases, which helped to differentiate AK from cancer in situ, in which such vessels were found in 40%. Glomerular vessels are not met in our study and the points were only 2.45% of the cases. Keratotic AK was characterized in 100% of cases the presence of keratin scales. In pigment form, we revealed the dark brown streaks (80%), dark brown points (50%), brown globules (30%), dark brown blots (10%) and slate-grey dots (10%). But the gold standard for the differential diagnosis with maligna lentigo is a morphological study. Conclusion: AK has specific characteristics in treatment research, which helps to differentiate it from other benign and malignant tumors of the skin, and to diagnose it in its earliest stages without resorting to invasive procedures. Effective diagnosis of AK reduces the risk of malignant transformation and contribute to the selection of adequate and necessary treatment tactics.
Vestnik dermatologii i venerologii. 2017;93(2):45-52
pages 45-52 views

Can the lesions induced with actinic keratosis become an enigma for dermatologists? Results of an open perspective study

Bujnauskajte E..., Rubins S..., Rubins A..., Makstiene Y..., Bujnauskiene Y...

Abstract

Different face skin diseases (basal cell carcinoma, actinic keratosis, rosacea, solar elastosis, etc.) could clinically manifest itself as erythematic patches, pimples or plagues. It is very hard to make the clinical exclusion in some cases of these diseases since their characters can partially overlap or certain lesion can mimic another one especially in the cases of skin areas affected with sun. Therefore, the histopathological analysis remains the “golden standard” of the dermatological diagnosis at skin diseases. Our study has shown that certified dermatologists detect actinic keratosis (AK) of face/head skin of I/II levels very well. Verdicts of dermatologists and pathomorfologists are congruent on account of diagnosis in 90,7% cases. Diseases clinically excluded as AK revealed as malignant neoplasms (basal cell carcinoma) in less than 1% of case lesions.
Vestnik dermatologii i venerologii. 2017;93(2):53-59
pages 53-59 views

Urticaria in children: pathogenetic mechanisms and the possibilities of modern therapy

Kudryavceva A.V., Neskorodova K.A.

Abstract

The review collected the latest literature data on urticaria - one of the most frequent skin diseases in children, accompanied by the appearance of blisters. It is notorious that histamine-liberation lies in the basis of the disease pathogenesis, regardless of the cause provoking an exacerbation. Precisely this explains the unified principle of therapy for all variants of urticaria -the administration of non-sedating antihistamines in the first line. Urticaria is classified for acute and chronic based on the duration of the course (up to 6 weeks or more). Experts do not recommend that physicians carry out any special diagnostic measures in the acute form of the disease, paying the utmost attention to the administration of effective treatment. the review describes the causes of disease exacerbation, the pathogenesis and the clinic of urticaria. Attention is paid to various options for managing patients with urticaria, published in the latest expert recommendations in Europe, America and Russia.
Vestnik dermatologii i venerologii. 2017;93(2):73-82
pages 73-82 views

New opportunities in the therapy of steroid-specific dermatosis - combination of topical glucocorticosteroid with urinium

Filimonkova N.N., Kolbina M.S.

Abstract

External therapy with topical steroids is used for a long time. To date topical glucocorticosteroids (TGCS) are in the leading position in dermatology among all medicines for external therapy. TGCS as a powerful tool of pathogenic action can rapidly reduce or decrease inflammatory changes in the skin and eliminate subjective symptoms of dermatoses (itching, burning). their positive effect lead to the rehabilitation of working ability and daily living activity, positively affect the psychoemotional state and significantly improve the patient’s quality of life. Urea in dermatology has been used for a very long time, as it softens the skin, reduces its dryness and eliminates peeling. In recent decades interest in this compound has intensified after a formation of an idea about natural moisturizing factor (NMF) - a complex of substances (which includes urea) being a part of the intercellular matrix of the epidermis and capable of retaining the water in the epithelial layer of the skin necessary for its normal functioning. The article presents modern literature data on the reasoning of the inclusion of a combination of topical glucocorticosteroids with urea in a complex therapy of steroid-responsive dermatoses.
Vestnik dermatologii i venerologii. 2017;93(2):83-88
pages 83-88 views

MEDICAL HISTORY

On the 115th anniversary of the dermatovenereology department of the academician I. P. Pavlov First St. Petersburg State Medical University (part II)

Krasnoselskikh T.V., Sokolovskiy E.V.

Abstract

The article explores the history of the Department of Dermatovenereology of the First St. Petersburg State Medical University from 1956 till present time. During this period the invaluable contribution to the development of the Department was made by eminent clinicians and scientists A. N. Aravijsky and I. M. Raznatovsky. Over the past 20 years, the department has been successfully developed under the leadership of professor Evgeny Vladislavovich Sokolovskiy.
Vestnik dermatologii i venerologii. 2017;93(2):89-96
pages 89-96 views

Aggressive systemic mastocytosis with skin involvement, the type of generaled urticaria pigmentosa (clinical case)

Sokolovskiy E.V., Iastrebov V.V., Shcherbatykh A.V., Machulaitene E.R.

Abstract

The authors describe the clinical observation of a case of the aggressive systemic mastocytosis with skin involvement, the type of generalized urticaria pigmentosa. They also present literature data concerning the etiology, pathogenesis, diagnosis and treatment of dermatosis.
Vestnik dermatologii i venerologii. 2017;93(2):60-63
pages 60-63 views

Acquired bullous epidermolysis: complexity of diagnostics

Al'banova V.I., Nefedova M.A.

Abstract

The article describes the case of acquired bullous epidermolysis in a woman of 45 years old, suffering from a disease from 2.5 years. As a child, she was diagnosed with herpetiform dermatitis on the base of a clinical picture and histological data. After the period of puberty, when in addition to skin blistering a lesion of the oral mucosa, dystrophy and absence of nail plates, contracture of the 2 fingers of the hands arose, the diagnosis was changed to dystrophic congenital bullous epidermolysis, which did not contradict with re-histological examination of the skin. In order to clarify the diagnosis, another biopsy of the leg skin was performed in 2016. The light microscopy data corresponded to the herpetiform dermatitis or vesicular form of the bullous pemphigoid, the acquired bullous epidermolysis was not also excluded. Indirect RIF allowed to reject the diagnosis of herpetiform dermatitis. The possibility of bullous pemphigoid developing on the background of preexisting congenital bullous epidermolysis was investigated by immunofluorescence mapping with antibodies to 13 structural proteins of the dermo-epidermal junction. Expression of all the studied proteins corresponded to that of healthy individuals, which conflicted with the diagnosis of congenital bullous epidermolysis. Additional immunofluorescence study of the sites of spontaneous cleavage of the biopsy specimen, as well as of n- and u-patterns in the structure of the luminescence line, made possible to exclude the bullous pemphigoid. So, the use of a complex of immunomorphological methods helped to establish the correct diagnosis.
Vestnik dermatologii i venerologii. 2017;93(2):64-72
pages 64-72 views

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