Широкое многообразие кератинов человека

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Представлены систематизированные данные о разнообразии кератинов человека. Обобщены результаты многочисленных исследований в области изучения структуры и функций кератинов, их распределения в различных клетках и тканях организма. Обсуждаются роль данных белков в развитии наследственных заболеваний человека, а также современные подходы к использованию кератинов в иммуногистохимии и перспективы их дальнейших исследований.

Об авторах

М. М. Юнусбаева

ФГБУН Институт биохимии и генетики

Автор, ответственный за переписку.
Email: milyausha_ufa@mail.ru
Россия

Б. Б. Юнусбаев

ФГБУН Институт биохимии и генетики

Email: noemail@neicon.ru
Россия

Р. Р. Валиев

ФГБОУ ВПО «Башкирский государственный университет»

Email: noemail@neicon.ru
Россия

А. А. Хамматова

ГАУЗ Республиканский кожно-венерологический диспансер № 1

Email: noemail@neicon.ru
Россия

Э. К. Хуснутдинова

ФГБУН Институт биохимии и генетики

Email: noemail@neicon.ru
Россия

Список литературы

  1. Schweizer J., Bowden P. E., Coulombe P. A., Langbein L., Lane E.B., Magin T. M., Maltais L., Omary M.B., Parry D.A., Rogers M.A., Wright M.W. New consensus nomenclature for mammalian keratins. JCB 2006; 174 (2): 169-174.
  2. Hesse M., Magin T.M., and Weber K. Genes for intermediate filament proteins and the draft sequence of the human genome: novel keratin genes and a surprisingly high number of pseudogenes related to keratins 8 and 18. J Cell Sci 2001; 114: 2569-2575.
  3. Hesse M., Zimek A., Weber K., Magin T.M. Comprehensive analysis of keratin gene clusters in humans and rodents. Eur. J Cell Biol 2004; 83: 19-26.
  4. Rogers M.A., Winter H., Langbein L., Bleiler R., Schweizer J. The human type I keratin gene family: Characterization of new hair follicle specifi c members and evaluation of the chromosome 17q21.2 gene domain. Differentiation 2004; 72: 527-540.
  5. Rogers M.A., Edler L., Winter H., Langbein L., Beckman I., Schweizer J. Characterization of new members of the human type II keratin gene family and a general evaluation of the keratin gene domain on chromosome 12q13.13. J Invest. Dermatol 2005; 124: 536-544.
  6. Omary M. B., Ku Nam-On, Strnad P., Hanada S. Toward unraveling the complexity of simple epithelial keratins in human disease J Clin Invest 2009; 119: 1794-1805.
  7. Moll R., Divo M., Langbein L. The human keratins: biology and pathology. Histochem Cell Biol 2008; 129: 705-733.
  8. Magin T.M., Vijayaraj P., Leube R.E. Structural and regulatory functions of keratins. Exp Cell Res 2007; 313 (10): 2021-2032.
  9. Lamb R.C., Lang J., Terron-Kwiatowski A., Baty D., McLean W.H., Zamiri M. Avascular necrosis of the hip and diffuse idiopathic skeletal hyperostosis during long-term isotretinoin treatment of epidermolytic ichthyosis due to novel deletion mutation in keratin 10. Br J Dermatol 2014; Apr 10. doi: 10.1111/bjd.13049.
  10. Kimonis V., DiGiovanna J.J., Yang J.-M., Doyle S.Z., Bale S.J., Compton J. G. A mutation in the V1 end domain of keratin 1 in non-epidermolytic palmar-plantar keratoderma. J Invest Derm 1994; 103: 764-769.
  11. Ishida-Yamamoto A., Takahashi H. and lizuka H. Lessons from disorders of epidermal differentiation-associated keratins. Histol Histopathol 2002; 17: 331-338.
  12. Whittock N.V., Smith F.J., Wan H., Mallipeddi R., Griffiths W.A., Dopping-Hepenstal P., Ashton G.H., Eady R.A., McLean W.H.I., McGrath J.A. Frameshift mutation in the V2 domain of human keratin 1 results in striate palmoplantar keratoderma. J Invest Derm 2002; 118: 838-844.
  13. Moravcova M., Libra A., Dvorâkovâ J., Viskova A., Muthny T., Velebny V., Kubala L. Modulation of keratin 1, 10 and involucrin expression as part of the complex response of the human keratinocyte cell line HaCaT to ultraviolet radiation. Interdiscip Toxicol 2013; 6 (4): 203-8.
  14. Schulte T., Lofling J., Mikaelsson C., Kikhney A., Hentrich K., Diamante A., Ebel Ch., Normark S., Svergun D., Henriques-Normark B., Achour A. The basic keratin10-binding domain of the virulence-associated pneumococcal serine-rich protein PsrP adopts a novel MSCRAMM fold. Open Biol 2013; 4 (1): 130090.
  15. Rothnagel J. A., Traupe H., Wojcik S., Huber M., Hohl D., Pittelkow M. R., Saeki H., Ishibashi Y., Roop D. R. Mutations in the rod domain of keratin 2e in patients with ichthyosis bullosa of Siemens. Nature Genet 1994; 7: 485-490.
  16. Epishev R.V., Chikin V.V., Volnuhin V.A., Kappusheva I.A., Trukhachev M.M. Recessive dystrophic epidermolysis bullosa: a case study. Vestn Dermatol Venerol 2013; (6): 94-99 [
  17. Епишев Р.В., Чикин В.В., Волнухин В.А. Каппушева И.А., Трухачев М.М. Рецессивный дистрофический буллезный эпидермолиз клиническое наблюдение. Вестн дерматол и венерол 2013; (6): 94-99.]
  18. Fischer H., Langbein L., Reichelt J., PraetzelWunder S., Buchberger M., Ghannadan M., Tschachler E., Eckhart L. Loss of Keratin K2 Expression Causes Aberrant Aggregation of K10, Hyperkeratosis and Inflammation. J Invest Dermatol 2014; Apr 21. doi: 10.1038/jid.2014.197.
  19. Irvine A.D., Corden L.D., Swensson O., Swensson B., Moore J.E., Frazer D.G., Smith F.J.D., Knowlton R.G., Christophers E., Rochels R., Uitto J., McLean W.H.I. Mutations in cornea-specific keratin K3 or K12 genes cause Meesmann's corneal dystrophy. Nature Genet 1997; 16: 184-187.
  20. Kao W.W., Liu C.Y., Converse R.L., Shiraishi A., Kao C.W., Ishizaki M., Doetschman T., DuVy J. Keratin 12-deficient mice have fragile corneal epithelia. Invest Ophthalmol Vis Sci 1996; 37 (13): 2572-2584.
  21. Moll R. Cytokeratins as markers of differentiation in the diagnosis of epithelial tumors. Subcell Biochem 1998; 31: 205-262.
  22. Malzahn K., Mitze M., Thoenes M., Moll R. Biological and prognostic significance of stratified epithelial cytokeratins in infiltrating ductal breast carcinomas. Virchows Arch 1998; 433 (2): 119-129.
  23. Мордовцев В.Н., Мордовцева В.В., Мордовцева В.В. Наследственные болезни и пороки развития кожи (атлас). М: Наука, 2004.
  24. Ficial M., Antonaglia C., Chilosi M., Santagiuliana M., Al-Omoush Tahseen. Keratin-14 Expression in Pneumocytes as a Marker of Lung Regeneration/Repair during Diffuse Alveolar Damage. American Journal of Respiratory and Critical Care Medicine 2014; 189 (9): 1142-1145.
  25. Lovaglio J., Artwohl J.E., Ward C.J., Diekwisch T.G., Ito Y., Fortman J.D. Case study: polycystic livers in a transgenic mouse line. Comp Med 2014; 64 (2): 115-20.
  26. Waseem A., Dogan B., Tidman N., Alam Y., Purkis P., Jackson S., Lalli A., Machesney M., Leigh I.M. Keratin 15 expression in stratified epithelia: downregulation in activated keratinocytes. J Invest Dermatol 1999; 112 (3): 362-369.
  27. Porter R.M., Lunny D.P., Ogden P.H., Morley S.M., McLean W.H., Evans A., Harrison D.L., Rugg E.L., Lane E.B. K15 expression implies lateral differentiation within stratified epithelial basal cells. Lab Invest 2000; 80 (11): 1701-1710.
  28. Lyle S., ChristoWdou-Solomidou M., Liu Y., Elder D.E., Albelda S., Cotsarelis G. (1998) The C8/144B monoclonal antibody recognizes cytokeratin 15 and defines the location of human hair follicle stem cells. J Cell Sci 111 (Pt 21): 3179-3188.
  29. Lyle S., Christofidou-Solomidou M., Liu Y., Elder D.E., Albelda S., Cotsarelis G. Human hair follicle bulge cells are biochemically distinct and possess an epithelial stem cell phenotype. J Investig Dermatol Symp Proc 1999; 4 (3): 296-301.
  30. Perrin C., Langbein L., Schweizer J. Expression of hair keratins in the adult nail unit: An immunohistochemical analysis of the onychogenesis in the proximal nail fold, matrix and nail bed. Br J Dermatol 2000; 151: 362-371.
  31. Langbein L., Schweizer J. Keratins of the human hair follicle. Int Rev Cytol 2005; 243: 1-78.
  32. Machesney M., Tidman N., Waseem A., Kirby L., Leigh I. Activated keratinocytes in the epidermis of hypertrophic scars. Am J Pathol 1998; 152 (5): 1133-41.
  33. Mommers J.M., Goossen J.W., van De Kerkhof P.C., van Erp P.E. Novel functional multiparameter flow cytometric assay to characterize proliferation in skin. Cytometry 2000; 42 (1): 43-49.
  34. Upasani O.S., Vaidya M.M., Bhisey A.N. Database on monoclonal antibodies to cytokeratins. Oral Oncol 2004; 40 (3): 236-56.
  35. Leigh I.M., Navsaria H., Purkis P.E., McKay I.A., Bowden P.E., Riddle P.N. Keratins (K16 and K17) as markers of keratinocyte hyperproliferation in psoriasis in vivo and in vitro. Br J Dermatol 1995; 133 (4): 501-511.
  36. Paladini R.D., Takahashi K., Bravo N.S., Coulombe P.A. Onset of re-epithelialization after skin injury correlates with a reorganization of keratin filaments in wound edge keratinocytes: defining a potential role for keratin 16. J Cell Biol 1996; 132 (3): 381-397.
  37. Wojcik S.M., Bundman D.S., Roop D.R. Delayed wound healing in keratin 6a knockout mice. Mol Cell Biol 2000; 20 (14): 5248-5255.
  38. Wong P., Colucci-Guyon E., Takahashi K., Gu C., Babinet C., Coulombe P.A. Introducing a null mutation in the mouse K6alpha and K6beta genes reveals their essential structural role in the oral mucosa. J Cell Biol 2000; 150 (4): 921-928.
  39. Wojcik S.M., Longley M.A., Roop D.R. Discovery of a novel murine keratin 6 (K6) isoform explains the absence of hair and nail defects in mice deficient for K6a and K6b. J Cell Biol 2001; 154 (3): 619-630.
  40. Langbein L., Rogers M.A., Praetzel S., Aoki N., Winter H., Schweizer J. A novel epithelial keratin, K6irs1, is expressed differentially in all layers of the inner root sheath, including specialized huxley cells (Flügelzellen) of the human hair follicle. J Invest Dermatol 2002; 118 (5): 789-799.
  41. Langbein L., Rogers M.A., Praetzel S., Winter H., Schweizer J. K6irs1, K6irs2, K6irs3, and K6irs4 represent the inner-root-sheath-specific type II epithelial keratins of the human hair follicle. J Invest Dermatol 2003; 120 (4): 512-522.
  42. Langbein L., Rogers M.A., Praetzel S., Cribier B., Peltre B., Gassler N., Schweizer J. Characterization of a novel human type II epithelial keratin K1b, specifically expressed in eccrine sweat glands. J Invest Dermatol 2005; 125 (3): 428-444.
  43. Schmelz M., Moll R., Hesse U., Prasad A.R., Gandolw J.A., Hasan S.R., Bartholdi M., Cress A.E. Identification of a stem cell candidate in the normal human prostate gland. Eur J Cell Biol 2005; 84 (2-3): 341-354.
  44. Moll R., Franke W.W., Volc-Platzer B., Krepler R. Different keratin polypeptides in epidermis and other epithelia of human skin: a specific cytokeratin of molecular weight 46,000 in epithelia of the pilosebaceous tract and basal cell epitheliomas. J Cell Biol 1982; 95 (1): 285-295.
  45. Perrin C., Langbein L., Schweizer J. Expression of hair keratins in the adult nail unit: An immunohistochemical analysis of the onychogenesis in the proximal nail fold, matrix and nail bed. Br J Dermatol 2004; 151: 362-371.
  46. Tong X., Coulombe P.A. Keratin 17 modulates hair follicle cycling in a TNF alpha-dependent fashion. Genes Dev 2006; 20 (10): 1353-1364.
  47. Paladini R.D., Takahashi K., Bravo N.S., Coulombe P.A. Onset of re-epithelialization after skin injury correlates with a reorganization of keratin filaments in wound edge keratinocytes: defining a potential role for keratin 16. J Cell Biol 1996; 132 (3): 381-397.
  48. Mazzalupo S., Wong P., Martin P., Coulombe P.A. Role for keratins 6 and 17 during wound closure in embryonic mouse skin. Dev Dyn 2003; 226 (2): 356-365.
  49. Kim S., Wong P., Coulombe P.A. A keratin cytoskeletal protein regulates protein synthesis and epithelial cell growth. Nature 2006; 441 (7091): 362-365.
  50. Zhang W., Dang E., Shi X., Jin L., Feng Z., Hu L., Wu Y., Wang G. The pro-inflammatory cytokine IL-22 up-regulates keratin 17 expression in keratinocytes via STAT3 and ERK1/2. PLoS One 2012; 7(7): e40797. doi: 10.1371/journal. pone.0040797.
  51. Fu M., Wang G. Keratin 17 as a therapeutic target for the treatment of psoriasis. J Dermatol Sci. 2012; 67 (3): 161-165.
  52. Jin L., Wang G. Keratin 17: a critical player in the pathogenesis of psoriasis. Med Res Rev 2014; 34 (2): 438-54.
  53. Owens D.W., Lane E.B. The quest for the function of simple epithelial keratins. Bioessays 2003; 25 (8): 748-758.
  54. Jaquemar D., Kupriyanov S., Wankell M., Avis J., Benirschke K., Baribault H., Oshima R.G. Keratin 8 protection of placental barrier function. J Cell Biol 2003; 161 (4): 749-756.
  55. Weerasinghe S.V., Ku N.O., Altshuler P.J., Kwan R., Omary M. B. Mutation of caspasedigestion sites in keratin 18 interferes with filament reorganization, and predisposes to hepatocyte necrosis and loss of membrane integrity. J Cell Sci 2014; 127 (7): 1464-1475.
  56. Magin T.M., Vijayaraj P., Leube R.E. Structural and regulatory functions of keratins. Exp Cell Res 2007; 313 (10): 2021-2032.
  57. Galarneau L., Loranger A., Gilbert S., Marceau N. Keratins modulate hepatic cell adhesion, size and G1/S transition. Exp Cell Res 2007; 313 (1): 179-194.
  58. Hesse M., Franz T., Tamai Y., Taketo M.M., Magin T.M. Targeted deletion of keratins 18 and 19 leads to trophoblast fragility and early embryonic lethality. EMBO J 2000; 19 (19): 5060-5070.
  59. Ku N.O., Soetikno R.M., Omary M.B. Keratin mutation in transgenic mice predisposes to Fas but not TNF-induced apoptosis and massive liver injury. Hepatology 2003; 37 (5): 1006-1014.
  60. Owens D.W., Lane E.B. Keratin mutations and intestinal pathology. J Pathol 2004; 204 (4): 377-385.
  61. Han C.P., Hsu J.D., Li Y.J. Anticytokeratin CAM5.2 is not synonymous with CK8/18 monoclonal antibody; and anticytokeratin CAM5.2 can be a marker for cytokeratin 8 but not for cytokeratin 18 and 19. Am J Surg Pathol 2010; 34 (4): 595.
  62. Barak V., Goike H., Panaretakis K.W., Einarsson R. Clinical utility of cytokeratins as tumor markers. Clin Biochem 2004; 37 (7): 529-540.52 к № 5, 2015
  63. Chu P., Wu E., Weiss L.M. Cytokeratin 7 and cytokeratin expression in epithelial neoplasms: a survey of 435 cases. Mod Pathol 2000; 13 (9): 962-972.
  64. Kurzen H., Esposito L., Langbein L., Hartschuh W. Cytokeratins as markers of follicular differentiation: an immunohistochemical study of trichoblastoma and basal cell carcinoma. Am J Dermatopathol 2001;23 (6): 501-509.
  65. Shimomura Y., Wajid M., Petukhova L., Kurban M., Christiano A. M. Autosomal-dominant woolly hair resulting from disruption of keratin 74 (KRT74), a potential determinant of human hair texture. Am J Hum Genet 2010; 86: 632-638.
  66. Wasif N., ul-Hassan Naqvi S. K., Basit S., Ali N., Ansar M., Ahmad W. Novel mutations in the keratin-74 (KRT74) gene underlie autosomal dominant woolly hair/hypotrichosis in Pakistani families. Hum Genet 2011; 129: 419-424.
  67. Rogers M.A., Langbein L., Praetzel-Wunder S., Winter H., Schweizer J. Human hair keratin associated proteins (KAPs). Int Rev Cytol 2006; 251: 209-263.
  68. Naeem M., Wajid M., Lee K., Leal S.M., Ahmad W. A mutation in the hair matrix and cuticle keratin KRTHB5 gene causes ectodermal dysplasia of hair and nail type. J Med Genet 2006; 43 (3): 274-279.
  69. Battistella M., Carlson J.A., Osio A., Langbein L., Cribier B. Skin tumors with matrical differentiation: lessons from hair keratins, beta-catenin and PHLDA-1 expression. J Cutan Pathol 2014; 41 (5): 427-36.
  70. Rogers M.A., Edler L., Winter H., Langbein L., Beckmann I., Schweizer J. Characterization of new members of the human type II keratin gene family and a general evaluation of the keratin gene domain on chromosome 12q13.13. J Invest Dermatol 2005; 124 (3): 536-544.

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