Vol 91, No 5 (2015)

The article provides the overview of main tendencies of incidence of syphilis in Russian Federation in 2010-2014, incidence over time and structure of early, late and unspecified syphilis and neurosyphilis.

Reviewed scientific publications that define the location of foci of chronic infections in dermatology. Indicated by the currently existing problematic issues and their solutions.

State Research Center of Dermatovenereology and Cosmetology, Ministry of Healthcare of the Russian Federation

The aim of the study was to determine the level of cytokines in the serum of patients with psoriatic arthritis (PsA) and psoriasis vulgaris (Ps) and to identify key immune markers associated with clinical manifestations of psoriasis. Materials and methods. The study involved 52 patients with psoriatic arthritis (PsA) and 20 patients with psoriasis vulgaris (PS) by multiplex analysis of proteins using Bio-Plex device and commercial test kits 23-Plex and 27-Plex, 8-Plex. Assessment of the severity and prevalence of psoriatic skin lesions in patients was conducted by index PASI (Psoriasis Area and Severity Index). Indicators of acute-phase activity (ESR, CRP), CEC were defined in all patients. the comparison group consisted of patients with a diagnosis of patchy scleroderma (10 patients) and patients with atopic dermatitis (10 patients). 13 healthy individuals were examined as a control group. Main results. Significant elevation of cytokines: IL-2, IL-6, GM-CSF, IFN-y and TNF-a was found in the serum of patients with PS compared with the group of apparently healthy individuals, and GM-CSF, IFN-y compared with patients with atopic dermatitis. It was determined that the detected levels of Il-В in serum has a direct correlation with the prevalence and severity of PS. Inverse correlation between ESR and the level of IL-8, GM-CSF and the CEC, IFN-y and the CEC and the direct correlation between the level of TNF-a and CRP in serum were shown. Conclusion. The obtained data indicate shifts in the system of pro-inflammatory and anti-inflammatory cytokines in psoriasis, which can be considered as a manifestation of endogenous homeostatic mechanisms designed to limit the intensity of the inflammatory process. Immune markers associated with clinical manifestations of psoriasis, in particular, the prevalence and severity of PS (index PASI), indicators of acute-phase activity (ESR, CRP), were identified.

Goal. To study and analyze the relationship of autoimmune diseases of the skin to sex and age. Materials and methods. Study of the relationship of autoimmune of skin diseases to sex and age was performed using contingency table analysis methods, which included the implementation of Pearson x² to test the hypothesis of independence of the two nominal attributes, calculation of standardized residual values, mapping the relevant category attributes using the method of correspondence analysis, calculation of coefficients of communication Pearson, Chuprova and Kramer. Differences were recognized to be statistically significant at the observed level of significance p < 0,05. In the analysis of standardized residuals were established the following conditions: if the absolute value of the standardized residuals ≥ 2, it was considered that the differences between the observed and expected frequencies are statistically significant at the 0,05 level, if standardized residue ≥ 2,6 the differences are significant at 0,01, if the residue standardized ≥ 3,3 the differences are significant at the 0,001 level. Results. Autoimmune skin diseases linked to sex and age of patients. Vitiligo is associated with male sex, localized scleroderma with women. Sex as a biological factor does not affect the appearance of alopecia areata, lupus erythematosus and bullous dermatosis. Age has in general a greater influence on the formation of autoimmune dermatoses. Alopecia areata is associated in the age period 0-14 and 30-44 years, vitiligo with age period 18-29 years, bullous dermatosis linked to the age group 60 years and older. Conclusion. Sex and age have a differential impact on the formation of autoimmune dermatoses, as biological risk factors of their formation.

Monitoring of disseminated superficial actinic porokeratosis (DSAP) in patient suffering from plaque psoriasis treated by PUVA therapy was presented. DSAP is a rare skin disease developing in the result of keratosis disorder caused by solar radiation and appearing as clearly localized ringed or line plates. As patients with DSAP are sensitive to solar radiation, phototherapy is contraindicated for them. In this regard, subcutaneous injections of Methotrexate 10 mg once a week were prescribed to a patient suffering from psoriasis. Psoriatic rashes were regressed after the second injection, instead of them DSAP rashes remained.

The article presents the current literature data on the rationale for the inclusion in complex therapy (combined corticosteroid drugs) for patients with steroid-sensitive dermatoses complicated by secondary infection. This article contains information definitive studies of efficacy and safety of combination therapy of infected chronic dermatosis drug Akriderm GC.

I In current literature review the physicochemical properties, peculiarities of mode of action and pharmacokinetics of azelaic and influence of azelaic on pathogenetic aspects of acne are characterized.

Purpose. Determination of efficiency and tolerance of Sotret product in treatment of patients with different clinical forms and severe acne in three clinical investigations. Materials and methods. 103 patients with acne (moderate and severe acne, acne conglobata and acne inversa) were examined and treated. All patients underwent monotherapy with Sotret with clinical effectiveness assessment and records of adverse events. Results. Sotret therapy facilitated clinical remission of acne in 90-100% of cases. Adverse events were easily tolerated and were not serious. Conclusion. Established therapeutic efficiency of Sotret determines its potential in treating various severity and various forms of acne.

History of dermatology development in Russia and the USSR in 1950-1959. words: dermatological service in Russia and USSR in 1950-1959.