Email this article 
Acute inflammation phase proteins in cases of IgE-mediated and IgE-independent atopic dermatitis
- Authors: Burdina A.V.1, Zorina V.N.1, Korotkiy N.G.2, Shkolnikova T.V.1, Zorin N.A.1
-
Affiliations:
- Novokuznetsk State Institute of Postgraduate Medicine
- Pirogov Russian National Research Medical University
- Issue: Vol 90, No 4 (2014)
- Pages: 35-39
- Section: SHORT COMMUNICATION
- URL: https://vestnikdv.ru/jour/article/view/49
- DOI: https://doi.org/10.25208/0042-4609-2014-90-4-35-39
- ID: 49
Cite item
Full Text
Abstract
Goal. To determine the blood serum level of α2-macroglobulin (α2-MG), α1-antitrypsin (α1-AT), lactoferrin (LF) and albumin in patients with IgE-mediated and IgE-independent atopic dermatitis (AD). Materials and methods. The authors tested blood serum of 60 adult patients suffering from atopic dermatitis at the exacerbation stage (30 patients with IgE-mediated and 30 patients with IgE-independent atopic dermatitis) and 20 healthy donors in order to determine the level of these proteins by rocket immunoelectrophoresis, enzyme-linked immunosorbent assay and immunoturbidimetry methods. Major results. The albumin level is reliably reduced in case of IgE-mediated AD while the LF and α1-AT levels are increased, and concentrations of LF α1-AT and a2-MG are increased as compared to healthy people. There are differences between the level of LF, α2-MG and α1-AT. There was a statistically significant correlation between the LF levels and SCORAD score in both forms, and α2-MG and α1-AT only in case of IgE-independent AD. Conclusion. These results confirm the difference in the roles of these polyfunctional proteins in the pathogenesis of IgE-mediated and IgE-independent AD.
About the authors
A. V. Burdina
Novokuznetsk State Institute of Postgraduate Medicine
Author for correspondence.
Email: nastyaburdina@mail.ru
Russian Federation
V. N. Zorina
Novokuznetsk State Institute of Postgraduate Medicine
Email: noemail@neicon.ru
Russian Federation
N. G. Korotkiy
Pirogov Russian National Research Medical University
Email: noemail@neicon.ru
Russian Federation
T. V. Shkolnikova
Novokuznetsk State Institute of Postgraduate Medicine
Email: noemail@neicon.ru
Russian Federation
N. A. Zorin
Novokuznetsk State Institute of Postgraduate Medicine
Email: noemail@neicon.ru
Russian Federation
References
- Maintz L., Novak N. Modifications of the innate immune system in atopic dermatitis. J Innate Immun 2011; 3: 131-141.
- Kurchenko A.I. Sravnitel'naya kharakteristika immunogistokhimicheskoy kartiny ochagov porazheniy kozhi u bol'nykh IgE-zavisimoy i IgE-nezavisimoy formami atopicheskogo dermatita. Ukrainskiy medichniy chasopis 2006, 1 (51): 114-117. [Курченко А.И. Сравнительная характеристика иммуногистохимической картины очагов поражений кожи у больных IgE-зависимой и IgE-независимой формами атопического дерматита. Украiнский медичний часопис 2006; 1 (51): 114-117. ]
- Zorin N.A., Zorina V.N., Zorina R.M. The role of macroglobulin family proteins in regulation of inflammation processes Biomeditsinskaya khimiya 2006; 3: 229-238. [Зорин Н.А., Зорина В.Н., Зорина Р.М. Роль белков семейства макроглобулинов в регуляции воспалительных реакций. Биомедицинская химия 2006; 3: 229-238.]
- Eden E. Asthma and COPD in alpha-1 antitrypsin deficiency. Evidence for the Dutch hypothesis. COPD. 2010; 7 (5): 366-374.
- Legrand D., Elass E., Carpenter M., Mazurer J. Lactoferrin: a modulator of immune and inflammatory responses. Cell Mol Life Sci 2005; 62: 2549-2559.
- Aksel'sen N., Krell' Y., Veke B. Rukovodstvo po kolichestvennomu immunoelektroforezu. Moskva: Mir; 1977: 216 s. [Аксельсен Н., Крелль Й., Веке Б. Руководство по количественному иммуноэлектрофорезу. Москва: Мир; 1977: 216 с.]
- Zweiman B., Kaplan A.P., Tong L., Moskovitz A.R. Cytokine levels and inflammatory responses in developing late-phase allergic reactions in the skin. J Allergy Clin Immunol 1997, 100 (1): 104-109.
- Lundin A., Engström-Laurent A., Hällgren R., Michaëlsson G. Circulating hyaluronate in psoriasis. Br J Dermatol 1985; 112 (6): 663-671.
- Ol'shamovskaya A.O. Patogeneticheskoe i kliniko-laboratornoe obosnovanie naruzhnoy terapii atopicheskogo dermatita sredstvami, soderzhashchimi mochevinu: Avtoref. dis. na soiskanie uchenoy stepeni kand. med. nauk. SPb; 2011. [Ольшамовская А.О. Патогенетическое и клинико-лабораторное обоснование наружной терапии атопического дерматита средствами, содержащими мочевину: Автореф. дис.. канд. мед. наук. СПб; 2011].
- Zorina V.N., Shkol'nikova T.V., Burdina A.V. et al. Role of multifunctional protein immunomodulators in the pathogenesis of psoriasis in atopic dermatitis. Klin dermatol venerol 2013, 2: 11-15. [Зорина В.Н., Школьникова Т.В., Бурдина А.В. и соавт. Роль полифункциональных белков-иммуномодуляторов в патогенезе псориаза и атопического дерматита. Клин дерматол и венерол 2013, 2: 11-15].
- Wu S.M., Patel D.D., Pizzo S.V. Oxidized alpha2macroglobulin (alpha 2M) differentially regulates receptor binding by cytokines/growth factors: implications for tissue injury and repair mechanisms in inflammation. J Immunol 1998; 161 (8): 4356-4365.
Supplementary files
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).