Современные подходы к диагностике грибовидного микоза



Цитировать

Полный текст

Аннотация

Рассмотрены преимущества и недостатки современных методов диагностики грибовидного микоза.
Диагностика грибовидного микоза основывается главным образом на клинической картине заболевания, что представляет значительные трудности для врача-дерматовенеролога, особенно на ранних его стадиях, когда высыпания
отличаются большим разнообразием. Лабораторными методами подтверждения диагноза являются гистологическое
и иммунофенотипическое исследования биоптатов кожи из области поражения, а также определение клональности
Т-лимфоцитов в коже методом полимеразной ценной реакции.

Об авторах

Е В Братцева

ФГУ «ГНЦД Росмедтехнологий»

Email: brattseva_k@mail.ru
аспирант; ФГУ «ГНЦД Росмедтехнологий»

С В Ротанов

ФГУ «ГНЦД Росмедтехнологий»

доцент, ведущий научный сотрудник отдела лабораторной диагностики ИППП и болезнейкожи; д.м.н; ФГУ «ГНЦД Росмедтехнологий»

E V Bratseva

S V Rotanov

Список литературы

  1. Willemze R., Jaffe E.S., Burg G. et al. WHO-EORTC classification for cutaneous lymphomas. Blood 2005; 105: 3768-3785.
  2. Kim Y.H., Liu H.L., Mraz-Gernhard S. et al. Long-term outcome of 525 patients with mycosis fungoides and Sezary syndrome: clinical prognostic factors and risk for disease progression. Arch Dermatol 2003; 139: 857-866.
  3. Criscione V.D., Weinstock M.A. Incidence of cutaneous T-cell lymphoma in the United States, 1973-2002. Arch Dermatol 2007; 143: 854-859.
  4. Vakeva L., Pukkala E., Ranki A. Increased risk of secondary cancers in patients with primary cutaneous T cell lymphoma. J Invest Dermatol 2000; 115: 62-65.
  5. Лезвинская Е.М., Молочков В.А., Ларина Н.К. Заболеваемость злокачественными лимфомами кожи в Московской области и пути совершенствования лечебно-диагностической помощи больным. Росс. журн. кожн. и венерич. болезней. 2000; 4: 12-17.
  6. Tsianakas A., Kienast A.K., Hoeger P.H. Infantile-onset cutaneous T-cell lymphoma. Br J Dermatol 2008; 159: 1338-1341.
  7. Jackow C.M., McHam J.B., Friss A. et al. HLA-DR5 and DQB1*03 class II alleles are associ-ated with cutaneous T-cell lymphoma. J Invest Dermatol 1996; 107: 373-376.
  8. Lenane P., Powell F.C., O'Keane C. et al. Mycosis fungoides-a review of the management of 28 patients and of the recent literature. Int J Dermatol 2007; 46: 19-26.
  9. Pimpinelli N., Olsen E.A., Santucci M. et al. Defining early mycosis fungoides. J Am Acad Dermatol 2005; 53: 1053-1063.
  10. Whittaker S.J., Marsden J.R., Spittle M. et al. Joint British Association of Dermatologists and U.K. Cutaneous Lymphoma Group guidelines for the management of primary cutaneous T-cell lymphomas. Br J Dermatol 2003; 149: 1095-1107.
  11. Keehn C.A., Belongie I.P., Shistik G. et al. The diagnosis, staging, and treatment options for mycosis fungoides. Cancer Control 2007; 14: 102-111.
  12. Zackheim H.S., McCalmont T.H. Mycosis fungoides: the great imitator. J Am Acad Dermatol 2002; 47: 914-918.
  13. Rosen S.T., Querfeld C. Primary cutaneous T-cell lymphomas. Hematology Am Soc Hematol Educ Program 2006: 323-330, 513.
  14. Vergier B., de Muret A., Beylot-Barry M. et al. Transformation of mycosis fungoides: clinicopa-thological and prognostic features of 45 cases. French Study Group of Cutaneious Lymphomas. Blood 2000; 95: 2212-2218.
  15. Fraser-Andrews E.A., Woolford A.J., Russell-Jones R. et al. Detection of a peripheral blood T cell clone is an independent prognostic marker in mycosis fungoides. J Invest Dermatol 2000; 114: 117-121.
  16. Muche J.M., Lukowsky A., Asadullah K. et al. Demonstration of frequent occurrence of clonal T cells in the peripheral blood of patients with primary cutaneous T-cell lymphoma. Blood 1997; 90: 1636-1642.
  17. Vonderheid E.C., Diamond L.W., Lai S.M. et al. Lymph node histopathologic findings in cuta-neous T-cell lymphoma. A prognostic classification system based on morphologic assessment. Am J Clin Pathol 1992; 97: 121-129.
  18. Kim E.J., Lin J., Junkins-Hopkins J.M., Vittorio C.C., Rook A.H. Mycosis fungoides and sezary syndrome: an update. Curr Oncol Rep 2006; 8: 376-386.
  19. Willemze R., Meijer C.J. Classification of cutaneous T-cell lymphoma: from Alibert to WHO-EORTC.J Cutan Pathol 2006; 33 (Suppl 1): 18-26.
  20. Saada D., Lami M.C., Vabres P. et al. Mycosis fungoides presenting as annular erythema. Ann Dermatol Venereol 2005; 132: 35-37.
  21. Speron S., Gamelli R. Toxic epidermal necrolysis syndrome versus mycosis fungoides. J Burn Care Rehabil 1997; 18: 421-423.
  22. Gantcheva M., Lalova A., Broshtilova V. et al. Vesicular mycosis fungoides. J Dtsch Dermatol Ges 2005; 3: 898-900.
  23. Heliot I., Beylot-Barry M., Vergier B. et al. Cutaneous T-cell lymphoma bullosa: 2 cases. Ann Dermatol Venereol 2003; 130: 639-642.
  24. Spieth K., Grundmann-Kollmann M., Runne U. et al. Mycosisfungoides- type cutaneous T cell lymphoma of the hands and soles: a variant causing delay in diagnosis and adequate treatment of patients with palmoplantar eczema. Dermatology 2002; 205: 239-244.
  25. Kim S.T., Jeon Y.S., Sim H.J. et al. Clinicopathologic features and T-cell receptor gene rear-rangement findings of mycosis fungoides palmaris et plantaris. J Am Acad Dermatol 2006; 54: 466-471.
  26. Yoo S.S., Viglione M., Moresi M., Vonderheid E. Unilesional mycosis fungoides mimicking Bowen's disease. J Dermatol 2003; 30: 417-419.
  27. Liotta E.A., Turiansky G.W., Berberian B.J. et al. Unusual presentation of secondary syphilis in 2 HIV-1 positive patients. Cutis 2000; 66: 383-386, 389.
  28. Crum N.F. Disseminated coccidioidomycosis with cutaneous lesions clinically mimicking my-cosis fungoides. Int J Dermatol 2005; 44: 958-960.
  29. Choi T.S., Doh K.S., Kim S.H. et al. Clinicopathological and genotypic aspects of anticonvul-sant-induced pseudolymphoma syndrome. Br J Dermatol 2003; 148: 730-736.
  30. Кубанова А.А. (ред.) Клинические рекомендации. Дерматовенерология. М.: ДЭКС-Пресс, 2007.
  31. Guitart J., Kennedy J., Ronan S. et al. Histologic criteria for the diagnosis of mycosis fungoides: proposal for a grading system to standardize pathology reporting. J Cutan Pathol 2001; 28: 174-183.
  32. Smoller B.R., Detwiler S.P., Kohler S. et al. Role of histology in providing prognostic informa-tion in mycosis fungoides. J Cutan Pathol 1998; 25: 311-315.
  33. Santucci M., Biggeri A., Feller A.C. et al. Efficacy of histologic criteria for diagnosing early mycosis fungoides: an EORTC cutaneous lymphoma study group investigation. European Organization for Research and Treatment of Cancer. Am J Surg Pathol 2000; 24: 40-50.
  34. El-Darouti M.A., Marzouk S.A., Bosseila M. et al. Microscopic study of normal skin in cases of mycosis fungoides. Int J Dermatol 2006; 45: 1043-1046.
  35. Burg G., Kempf W. Cutaneous Lymphomas (Basic and Clinical Dermatology) Informa Health-care 2005; 592.
  36. Goeldel A.L., Cornillet-Lefebvre P., Durlach A. et al. T-cell receptor gamma gene rearrange-ment in cutaneous T-cell lymphoma: comparative study of polymerase chain reaction with denaturing gradi-ent gel electrophoresis and GeneScan analysis. Br J Dermatol 2009; 10 (http://www.wiley.com).
  37. Bergman R., Faclieru D., Sahar D. et al. Immunophenotyping and T-cell receptor gamma gene rearrangement analysis as an adjunct to the histopathologic diagnosis of mycosis fungoides. J Am Acad Dermatol 1998; 39: 554-559.
  38. Ormsby A., Bergfeld W.F., Tubbs R.R., Hsi E.D. Evaluation of a new paraffin-reactive CD7 T-cell deletion marker and a polymerase chain reaction-based T-cell receptor gene rearrangement assay: implications for diagnosis of mycosis fungoides in community clinical practice. J Am Acad Dermatol 2001; 45: 405-413.
  39. Smoller B.R., Santucci M., Wood G.S., et al. Histopathology and genetics of cutaneous T-cell lymphoma. Hematol Oncol Clin North Am 2003; 17: 1277-1311.
  40. Bernier C., Nguyen J.M., Quereux G. et al. CD13 and TCR clone: markers of early mycosis fungoides. Acta Derm Venereol 2007; 87: 155-159.
  41. Scala E., Narducci M.G., Amerio P. et al. T cell receptor-Vbeta analysis identifies a dominant CD60+ CD26- CD49d- T cell clone in the peripheral blood of Sezary syndrome patients. J Invest Dermatol 2002; 119: 193-196.
  42. Yoon J.S., Newton S.M., Wysocka M. et al. IL-21 enhances antitumor responses without stimu-lating proliferation of malignant T cells of patients with Sezary syndrome. J Invest Dermatol 2008; 128: 473-480.
  43. Novelli M., Comessati A., Quaglino P. et al. CD26 expression on cutaneous infiltrates from pa-tients with cutaneous T-cell lymphoma (CTCL) CD26 in cutaneous T-cell lymphoma patients. Adv Exp Med Biol 2003; 524: 223-234.
  44. Dummer R., Kamarashev J., Kempf W. et al. Junctional CD8+ cutaneous lymphomas with nonaggressive clinical behavior: a CD8+ variant of mycosis fungoides? Arch Dermatol 2002; 138: 199-203.
  45. Curco N., Servitje O., Llucia M. et al. Genotypic analysis of cutaneous T-cell lymphoma: a comparative study of Southern blot analysis with polymerase chain reaction amplification of the T-cell receptor- gamma gene. Br J Dermatol 1997; 137: 673-679.
  46. Khan N., Shariff N., Cobbold M. et al. Cytomegalovirus seropositivity drives the CD8 T cell repertoire toward greater clonality in healthy elderly individuals. J Immunol 2002; 169: 1984-1992.
  47. Jones D., Duvic M. The current state and future of clonality studies in mycosis fungoides. J In-vest Dermatol 2003; 121: ix-x.
  48. Dereure O., Balavoine M., Salles M.T. et al. Correlations between clinical, histologic, blood, and skin polymerase chain reaction outcome in patients treated for mycosis fungoides. J Invest Dermatol 2003; 121: 614-617.
  49. Delfau-Larue M.H., Dalac S., Lepage E. et al. Prognostic significance of a polymerase chain re-action-detectable dominant T-lymphocyte clone in cutaneous lesions of patients with mycosis fungoides. Blood 1998; 92: 3376-3380.
  50. Poszepczynska-Guigne E., Bagot M., Wechsler J. et al. Minimal residual disease in mycosis fungoides follow-up can be assessed by polymerase chain reaction. Br J Dermatol 2003; 148: 265-271.
  51. Vega F., Luthra R., Medeiros L.J. et al. Clonal heterogeneity in mycosis fungoides and its rela-tionship to clinical course. Blood 2002; 100: 3369-3373.
  52. Assaf C., Hummel M., Dippel E. et al. High detection rate of T-cell receptor beta chain rear-rangements in T-cell lymphoproliferations by family specific polymerase chain reaction in combination with the GeneScan technique and DNA sequencing. Blood 2000; 96: 640-646.
  53. Fink-Puches R., Wolf P., Kerl H., Cerroni L. Lichen aureus: clinicopathologic features, natural history, and relationship to mycosis fungoides. Arch Dermatol 2008; 144: 1169-1173.
  54. Hanna S., Walsh N., D'Intino Y., Langley R.G. Mycosis fungoides presenting as pigmented pur-puric dermatitis. Pediatr Dermatol 2006; 23: 350-354.
  55. Kandolf Sekulovic L., Cikota B., Stojadinovic O. et al. TCRgamma gene rearrangement analysis in skin samples and peripheral blood of mycosis fungoides patients. Acta Dermatovenerol Alp Panonica Adriat 2007; 16: 149-155.
  56. Cerroni L A.E., Ardigò M, Pütz B, Kerl H. Monoclonality of intraepidermal T lymphocytes in early mycosis fungoides detected by molecular analysis after laser-beam-based microdissection. J Invest Dermatol 2000; 114: 1154-1157.
  57. Delfau-Larue MH L.L., Wechsler J, Lepage E et al. Diagnostic value of dominant T-cell clones in peripheral blood in 363 patients presenting consecutively with a clinical suspicion of cutaneous lymphoma. Blood 2000; 96: 2987-2992.

Дополнительные файлы

Доп. файлы
Действие
1. JATS XML
Скачать

© Братцева Е.В., Ротанов С.В., Bratseva E.V., Rotanov S.V., 2010

Creative Commons License
Эта статья доступна по лицензии Creative Commons Attribution 4.0 International License.
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 60448 от 30.12.2014.


Данный сайт использует cookie-файлы

Продолжая использовать наш сайт, вы даете согласие на обработку файлов cookie, которые обеспечивают правильную работу сайта.

О куки-файлах