The influence of low and moderate doses of ultraviolet irradiation produced by the UFA-1 device possessing the wavelength of 350 to 400 nm on the parameters of skin inflammation in patients suffering atopic dermatitis



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Abstract

The performed investigation has shown that there is an increase of the content of CD4+ lymphocytes and an increased expression of γ-interferon in the skin of patients with atopic dermatitis comparing to healthy volunteers. Therapy with the use of UFA-1 produced more marked levels of γ-interferon positive cells in the skin (р = 0.004) in patients with clinical recovery compared to subjects with an achieved improvement, as well as a substantial reduction of the Т-helpers level within the effected skin areas (р = 0.009).

About the authors

A A Kubanov

Email: аlex@cnikvi.ru

I N Avdienko

References

  1. Атопический дерматит: рекомендации для практических врачей. Под ред. Хаитова Р. М., Кубановой А. А. М.: Фармус Принт. 2002; 192.
  2. Bieber T., Novak N. Pathogenesis of atopic dermatitis: new developments. Curr. Allergy Asthma Rep2009; 9: 291-294.
  3. Novak N. New insights into the mechanism and management of allergic diseases: atopic dermatitis. Allergy 2009; 64: 265-275.
  4. Schmid-Grendelmeier P., Simon D., Simon H. U. et al. Epidemiology, clinical features, and immunology of the «intrinsic» (non-IgE-mediated) type of atopic dermatitis (constitutional dermatitis). Allergy 2001; 56: 841-849.
  5. Elias P. M., Steinhoff M. «Outside-to-inside» (and now back to «outside») pathogenic mechanisms in atopic dermatitis. J. Invest. Dermatol. 2008; 128: 1067-1070.
  6. Дранник Г. Н. Клиническая иммунология и аллергология. М.: МИА. 2003; 604.
  7. Novak N., Bieber T., Leung D.Y. Immune mechanisms leading to atopic dermatitis. J. Allergy. Clin. Immunol. 2003. Vol. 112. р. S128-139.
  8. Сергеев Ю. В. Атопический дерматит: новые подходы к профилактике и наружной терапии. Рекомендации для врачей. М.: Медицина для всех. 2003; 56.
  9. Akdis C. A., Akdis M., Bieber T. et al. Diagnosis and treatment of atopic dermatitis in children and adults. J. Allergy. Clin. Immunol. 2006; 118: 152-169.
  10. Сергеев Ю. В., Новиков Д. К., Караулов А. В. и др. Атопический дерматит: гетерогенность клинических форм и разнообразие механизмов патогенеза. Иммунопатология, аллергология, инфектология. 2001; 61-73.
  11. Ring J., Pzrybilla B., Ruzicka T. Handbook of Atopic Eczema. Berlin: Springer, 2006. 615 p.
  12. Курченко А. И. Сравнительная характеристика иммуногистохимической картины очагов поражения кожи у больных с IgE-зависимой и IgE-независимой формами атопического дерматита. Український медичний часопис. 2006; 1: 114-117.
  13. Кунгуров Н. В. Иммунологические аспекты атопического дерматита. Вестн. дерматол. и венерол. 1999; 3: 14-17.
  14. Leung D. Y. Pathogenesis of atopic dermatitis. J. Allergy. Clin. Immunol. 1999; 104: S99-108.
  15. Mang R., Krutmann J. UVA-1 Phototherapy. Photodermatol. Pho- toimmunol. Photomed. 2005; 21: 103-108.
  16. Grewe M., Gyufko K., Schopf E., Krutmann J. Lesional expression of interferon-gamma in atopic eczema. Lancet 1994; 343: 25-26.
  17. Thepen T., Langeveld-Wildschut E. G., Bihari I. C. et al. Biphasic response against aeroallergen in atopic dermatitis showing a switch from an initial TH2 response to a TH1 response in situ: an immunocytochemical study. J. Allergy. Clin. Immunol. 1996; 97: 828-837.
  18. Spergel J. M., Mizoguchi E., Oettgen H. et al. Roles of TH1 and TH2 cytokines in a murine model of allergic dermatitis. J. Clin. Invest. 1999; 103: 1103-1111.
  19. Lugovic L., Lipozencic J., Jakic-Razumovic J. Prominent involvement of activated Th1-subset of T-cells and increased expression of receptor for IFN-gamma on keratinocytes in atopic dermatitis acute skin lesions. Int. Arch. Allergy. Immunol. 2005; 137: 125-133.
  20. Grewe M., Gyufko K., Krutmann J. Interleukin-10 production by cultured human keratinocytes: regulation by ultraviolet B and ultraviolet A1 radiation. J. Invest. Dermatol. 1995; 104: 3-6.
  21. Villa P., Kaufmann S. H., Earnshaw W. C. Caspases and caspase inhibitors. Trends. Biochem. Sci. 1997; 22: 388-393.
  22. Deiss L. P., Galinka H., Berissi H. et al. Cathepsin D protease mediates programmed cell death induced by interferon-gamma, Fas/APO-1 and TNF-alpha. EMBO J. 1996; 15: 3861-3870.
  23. X. X., F. X. Y., Plate J., Chong A. S. IFN-gamma induces cell growth inhibition by Fas-mediated apoptosis: requirement of STAT1 protein for up-regulation of Fas and FasL expression. Cancer. Res. 1998; 58: 2832-2837.
  24. Schroder K., Hertzog P. J., Ravasi T., Hume D. A. Interferon-gamma: an overview of signals, mechanisms and functions. J. Leukoc. Biol. 2004; 75: 163-189.

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