The influence of low and moderate doses of ultraviolet irradiation produced by the UFA-1 device possessing the wavelength of 350 to 400 nm on the parameters of skin inflammation in patients suffering atopic dermatitis

Abstract

The performed investigation has shown that there is an increase of the content of CD4+ lymphocytes and an increased expression of γ-interferon in the skin of patients with atopic dermatitis comparing to healthy volunteers. Therapy with the use of UFA-1 produced more marked levels of γ-interferon positive cells in the skin (р = 0.004) in patients with clinical recovery compared to subjects with an achieved improvement, as well as a substantial reduction of the Т-helpers level within the effected skin areas (р = 0.009).

About the authors

A A Kubanov

Email: аlex@cnikvi.ru

I N Avdienko

References

  1. Атопический дерматит: рекомендации для практических врачей. Под ред. Хаитова Р. М., Кубановой А. А. М.: Фармус Принт. 2002; 192.
  2. Bieber T., Novak N. Pathogenesis of atopic dermatitis: new developments. Curr. Allergy Asthma Rep2009; 9: 291-294.
  3. Novak N. New insights into the mechanism and management of allergic diseases: atopic dermatitis. Allergy 2009; 64: 265-275.
  4. Schmid-Grendelmeier P., Simon D., Simon H. U. et al. Epidemiology, clinical features, and immunology of the «intrinsic» (non-IgE-mediated) type of atopic dermatitis (constitutional dermatitis). Allergy 2001; 56: 841-849.
  5. Elias P. M., Steinhoff M. «Outside-to-inside» (and now back to «outside») pathogenic mechanisms in atopic dermatitis. J. Invest. Dermatol. 2008; 128: 1067-1070.
  6. Дранник Г. Н. Клиническая иммунология и аллергология. М.: МИА. 2003; 604.
  7. Novak N., Bieber T., Leung D.Y. Immune mechanisms leading to atopic dermatitis. J. Allergy. Clin. Immunol. 2003. Vol. 112. р. S128-139.
  8. Сергеев Ю. В. Атопический дерматит: новые подходы к профилактике и наружной терапии. Рекомендации для врачей. М.: Медицина для всех. 2003; 56.
  9. Akdis C. A., Akdis M., Bieber T. et al. Diagnosis and treatment of atopic dermatitis in children and adults. J. Allergy. Clin. Immunol. 2006; 118: 152-169.
  10. Сергеев Ю. В., Новиков Д. К., Караулов А. В. и др. Атопический дерматит: гетерогенность клинических форм и разнообразие механизмов патогенеза. Иммунопатология, аллергология, инфектология. 2001; 61-73.
  11. Ring J., Pzrybilla B., Ruzicka T. Handbook of Atopic Eczema. Berlin: Springer, 2006. 615 p.
  12. Курченко А. И. Сравнительная характеристика иммуногистохимической картины очагов поражения кожи у больных с IgE-зависимой и IgE-независимой формами атопического дерматита. Український медичний часопис. 2006; 1: 114-117.
  13. Кунгуров Н. В. Иммунологические аспекты атопического дерматита. Вестн. дерматол. и венерол. 1999; 3: 14-17.
  14. Leung D. Y. Pathogenesis of atopic dermatitis. J. Allergy. Clin. Immunol. 1999; 104: S99-108.
  15. Mang R., Krutmann J. UVA-1 Phototherapy. Photodermatol. Pho- toimmunol. Photomed. 2005; 21: 103-108.
  16. Grewe M., Gyufko K., Schopf E., Krutmann J. Lesional expression of interferon-gamma in atopic eczema. Lancet 1994; 343: 25-26.
  17. Thepen T., Langeveld-Wildschut E. G., Bihari I. C. et al. Biphasic response against aeroallergen in atopic dermatitis showing a switch from an initial TH2 response to a TH1 response in situ: an immunocytochemical study. J. Allergy. Clin. Immunol. 1996; 97: 828-837.
  18. Spergel J. M., Mizoguchi E., Oettgen H. et al. Roles of TH1 and TH2 cytokines in a murine model of allergic dermatitis. J. Clin. Invest. 1999; 103: 1103-1111.
  19. Lugovic L., Lipozencic J., Jakic-Razumovic J. Prominent involvement of activated Th1-subset of T-cells and increased expression of receptor for IFN-gamma on keratinocytes in atopic dermatitis acute skin lesions. Int. Arch. Allergy. Immunol. 2005; 137: 125-133.
  20. Grewe M., Gyufko K., Krutmann J. Interleukin-10 production by cultured human keratinocytes: regulation by ultraviolet B and ultraviolet A1 radiation. J. Invest. Dermatol. 1995; 104: 3-6.
  21. Villa P., Kaufmann S. H., Earnshaw W. C. Caspases and caspase inhibitors. Trends. Biochem. Sci. 1997; 22: 388-393.
  22. Deiss L. P., Galinka H., Berissi H. et al. Cathepsin D protease mediates programmed cell death induced by interferon-gamma, Fas/APO-1 and TNF-alpha. EMBO J. 1996; 15: 3861-3870.
  23. X. X., F. X. Y., Plate J., Chong A. S. IFN-gamma induces cell growth inhibition by Fas-mediated apoptosis: requirement of STAT1 protein for up-regulation of Fas and FasL expression. Cancer. Res. 1998; 58: 2832-2837.
  24. Schroder K., Hertzog P. J., Ravasi T., Hume D. A. Interferon-gamma: an overview of signals, mechanisms and functions. J. Leukoc. Biol. 2004; 75: 163-189.

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