The role of T-regulatory cells in the pathogenesis of psoriasis

Abstract

T-regulatory cells control the strength and duration of immune response and play an important role in the pathogenesis of
psoriasis. The goal of the study was to examine the content of T-regulatory cells in peripheral blood and affected skin of
psoriasis patients, the level of FOXP3 mRNA expression in psoriatic skin. Determination of subpopulations of T-regulatory
lymphocytes in peripheral blood was performed using flow cytometry. The median level of FOXP3 mRNA expression was
determined in biopsies of the skin by PCR in real time. Immunohistochemistry was performed with monoclonal anti-
FOXP3 antibodies. Revealed an increase in the relative content of T-regulatory cells in the peripheral blood of patients with
psoriasis in the progressive period, compared with healthy people. The level of FOXP3 mRNA expression in psoriatic foci
was 3.1 times higher than in healthy individuals. Was noted a 10-fold increase in the number of T-regulatory lymphocytes
in the skin of psoriasis patients in the progressive period, compared with skin from healthy donors.

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Copyright (c) 2011 Khayrutdinov V.R., Mikhaylichenko A.F., Mukhina M.S., Samtsov A.V., Imyanitov E.N., Ivanov A.M., KHAIRUTDINOV V.R., MICHAILICHENCO A.F., MUKHINA M.A., SAMTSOV A.V., IMYANITOV E.N., IVANOV A.M.

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