Vol 91, No 6 (2015)

Experimental models of leprosy

Kubanov A.A., Karamova A.E., Vorontsova A.A., Kalinina P.A.

Abstract

Leprosy (Hansen’s disease) is a chronic granulomatous bacterial disease which mainly affects skin and peripheral nervous system. Leprosy is caused by the obligate intercellular pathogen known as Mycobacterium leprae. Creating experimental models of leprosy is associated with serious problems due to biological characteristics of the pathogen. Numerous attempts to develop experimental models on different types of animals resulted in a few reproducible models on mice and nine-banded armadillos. Strains of knockout mice with genetic defects caused by site-directed mutagenesis are used as a basis for different leprosy models. Experimental models of leprosy are used for screening of anti-leprosy drugs, detection of drug resistance, studies on the pathogenesis of leprosy, production and evaluation of viability of M. leprae, developing of anti-leprosy vaccines.
Vestnik dermatologii i venerologii. 2015;91(6):17-29
pages 17-29 views

Androgenic hormone profile in patients with androgenetic alopecia

Konrakhina I.N., Mareeva A.N., Kalinina P.A., Abuladze M.G.

Abstract

In this article, the outcomes of the range of researches are described including the data on levels of testosterone, dihydrotestosterone, dehydroepiandrosterone sulfate, sex hormone-binding globulin and other components of androgen hormone profile in issues and biological fluids of males with androgenetic alopecia. Besides, in this article we describe results of recent studies devoted to effects of androgens on hair follicles and the role of 5-alpha reductase in conversion of androgens.
Vestnik dermatologii i venerologii. 2015;91(6):30-32
pages 30-32 views

The use of current genotyping assay methods for Neisseria gonorrhoeae

Shpilevaya M.V., Obraztsova O.A., Chestkov A.V.

Abstract

The review deals with up-to-date genotyping assay methods of Neisseria gonorrhoeae. The review covers the characteristics and features of each method, application areas of genotyping assay of Neisseria gonorrhoeae. The methods described enable to upgrade the diagnostication of gonococcal infection, predict its antibiotic resistance, trace the contagion and channels of the infection as well as study the processes of molecular evolution of the microorganism. Information obtained based on up-to-date N. gonorrhoeae genotyping assay methods can be used in developing the reproductive health strategy of the population.
Vestnik dermatologii i venerologii. 2015;91(6):33-40
pages 33-40 views

COSMETOLOGY

System of independent evaluation (confirmation) of correspondence of perfumes and cosmetics in the Russian Federation

Petrova N.P., Rezaikina A.V., Rotanov S.V.

Abstract

Purpose. Efficiency analysis of measures to determine the safety of samples of perfumes and cosmetics and quality of clinical and laboratory studies conducted by the test centre FGU “GNTSDK” under Ministry of Medicine, RF. Materials and methods. When evaluating the safety of tested samples of perfumes and cosmetics microbiological, physical and chemical, toxicological and clinical identification criteria were used. Investigation results of the samples were studied representing a total of about 80 thousand samples delivered to the ITS “GNTSDK” between 2012 and November 2015. Results and conclusion. Statistical processing of all kinds of studies makes it possible to arrive at a conclusion about the stability of tested volume at ITS “GNTSDK” within the period of 2012 - 2015. The analysis of certain types of tests shows the absence of negative dynamics of studies made which does not exclude a certain variation of frequency of using each method. The dynamics of conducting tests reflects the relevancy and efficiency of the centre activities in the service market.
Vestnik dermatologii i venerologii. 2015;91(6):90-96
pages 90-96 views

GUIDELINES FOR PRACTITIONERS

Psycho-emotional conditions of patients with non-cicatrazing alopecia (circumsribed, androgenetic)

Mareeva A.N., Kondrakhina I.N.

Abstract

Most common psycho-emotional disorders are described with patients with circumsribed, androgenetic alopecia. Main identification methods presented. It was shown based on analysis of literary data and in order to upgrade the quality of medical help for this group of patients how important it is to identify the preoccupying, depressive and other pathological psychogenic conditions of patients chronic alopecia.
Vestnik dermatologii i venerologii. 2015;91(6):50-56
pages 50-56 views

Clinical features and differential diagnostics of segmental vitiligo and nevus achromicus with children

Proshutinskaia D.V.

Abstract

Clinical presentation is given of eruption in the case of segmental vitiligo and nevus achromicus. Literary data was presented, issues of differential diagnostics were discussed.
Vestnik dermatologii i venerologii. 2015;91(6):57-60
pages 57-60 views

Phototherapy of extragenital white spot disease

Volnukhin B.A., Znamenskaya L.F., Kappusheva I.A., Muradyan N.L., Dvornikov A.S.

Abstract

Objective. To study the effectiveness of UVA1therapy and PUVA therapy in patients with extragenital lichen sclerosus. Materials and methods. Effectiveness of the phototherapy methods was studied in 12 patients with extragenital lichen sclerosus (8 women, 4 men) aged from 19 to 61 years old with the disease history of 1-25 years. 6 patients received UVA1therapy while 3 patients received general PUVA therapy and 3 patients - local PUVA therapy. All the patients underwent phototherapy in the form of monotherapy. Results. After the treatment clinical improvement was observed in 6 patients from the UVA1 group (100%) and 4 patients from the PUVA group (66.7%), significant improvement of clinical picture and clinical remission were registered in 1 (16.7%) and 2 (33.3%) patients from the PUVA group, respectively. Phototherapy caused partial or full regress of main lichen sclerosus symptoms: sclerosis, induration, erythema, epidermal atrophy and skin hypopigmentation. The tolerability of treatment was satisfying, serious adverse effects were not reported. Conclusion. Conducted research indicates the effectiveness of UVA1therapy and PUVA therapy in patients with extragenital lichen sclerosus. Phototherapy may be a choice in the management of the disease.
Vestnik dermatologii i venerologii. 2015;91(6):61-66
pages 61-66 views

Application of a preparation of imiquimod in а dosage form of ointment 5% in therapy of basal cell carcinoma

Zaslavsky D.V., Chuprov I.N., Sidikov A.A., Wolkensteyn P., Sadykov A.I., Sibgatullin R.R., Koval Y.G., Skrek S.V.

Abstract

Objective. To estimate efficiency and safety of application of a preparation of Aldara (imiquimod, 5% external application cream) it is independent or in combination with cryotherapy in therapy of the basal cell carcinoma of the skin (BCC). Material and methods. Research included 78 patients (22 women and 56 men) with various forms of a basal cell carcinoma of the skin. All patients were divided into 3 groups: the main group (n = 30) the patients receiving therapy by Aldara (imiquimod, 5% external application cream) made, second (n = 21) - the patients receiving therapy by Aldara’s, and also 1 course of cryotherapy, and the group of comparison (n = 27) receiving therapy of placebo in the form of external application cream. Therapy was carried out 3 times a week, within 16 weeks. Research was conducted in some stages with histologic confirmation of the diagnosis, and also an assessment of efficiency of therapy and undesirable effects. Results. At 27 of 30 patients of the first group (90%) and at 21 of 21 patients of the second group (100%) receiving treatment by Aldara’s absolute clinical recovery is reached. In group of comparison of clinical recovery at all 27 patients it wasn’t observed. It is expedient to note that at all patients of the second group (100%) already to 75 ± to the 2nd day of therapy (the 4th visit) clinical recovery while at 27 of 30 patients of the first group (90%) the total disappearance (clinical recovery) came for 105 and more days (the 5th and 6th visits) was noted. Recurrence of a disease after the end of therapy it wasn’t observed. Conclusion. Aldara (imiquimod, 5% external application cream) possesses high efficiency at therapy of various forms and sizes of BCC. Undesirable effects of therapy are easily resolved at cancellation of a preparation and not observed at its renewal. Unlike other immunomodulatory preparations (corticosteroids, retinoid, cyclosporin) Aldar’s application doesn’t promote suppression of cellular immunity.
Vestnik dermatologii i venerologii. 2015;91(6):67-74
pages 67-74 views

Nummular eczema in children and adults: clinical picture and differential therapy approaches

Proshutinskaia D.B., Skripkina P.A.

Abstract

The article deals with present-day ideas on pathogenesis and treatment of Nummular eczema, differences between clinical I picture of the disease with children and adults.
Vestnik dermatologii i venerologii. 2015;91(6):85-89
pages 85-89 views

CLINICAL GUIDELINES

Guidelines for treatment of atopic dermatitis (atopic eczema) from American Academy of Dermatology, European Academy of Dermatology and Venereology and Russian Society of Dermatovenereologists and Cosmetologisis. Expert’s opinion

Samtzov A.V., Sokolovsky E.V., Araviiskaia E.A.

Abstract

Atopic dermatitis (AD) is a common skin condition treated by dermatologists all over the world. Guidelines for management and treatment of AD have appeared in Europe, USA and Russia recently. the paper contains comparison of European, American and Russian guidelines. Definition of AD, epidemiology, pathophysiology of the disease, clinical features, diagnostic criteria, and risk factors are consistently matched. the analysis demonstrated that guidelines do not contain serious contradictions and principal differences thus stressing their supplementation of each other.
Vestnik dermatologii i venerologii. 2015;91(6):11-16
pages 11-16 views

The clinical case of Sneddon - Wilkinson disease in a pregnant woman

Askhakov M.S., Chebotarev V.V., Odinec A.V.

Abstract

Describes a rare clinical case demonstrating the sudden appearance of the disease Sneddon - Wilkinson in women during pregnancy, which regressed completely within a month after birth and had no recurrence.
Vestnik dermatologii i venerologii. 2015;91(6):75-78
pages 75-78 views

A case of generalized pustular psoriasis

Oklopkov V.A., Pravdina O.V., Chermoschentsev A.A., Repina T.V., Poleshuk E.I., Gudoshnik V.G., Gorodilov R.V.

Abstract

The article presents a clinical case of generalized pustular psoriasis. Complex therapy features for this rare and severe type of psoriasis are described.
Vestnik dermatologii i venerologii. 2015;91(6):79-84
pages 79-84 views

Pathomorphological changes in patients with Jessner>s lymphocytic infiltrate of skin, reticular erythematous mucinosis and lupus tumidus

Trophymov P.N., Antonova O.V., Khairutdinov V.R., Belousova I.E., Samtsov A.V.

Abstract

Jessner’s lymphocytic infiltrate of skin, reticular erythematous mucinosis and lupus tumidus are the group of rare, insufficiently explored dermatosis with common clinical and histological features, whose nosology is controversial today. Plasmacytoid dendritic cells play the key role in autoimmune disease induction The target of our study was the analysis of pathomorphological features of lesional skin and the research of plasmacytoid dendritic cells in the skin of patients with Jessner’s lymphocytic infiltrate of skin, reticular erythematous mucinosis and lupus tumidus. Material and methods. Histological and indirect immunohistochemistry examination (anti-CD123 antibodies) of lesional skin of 36 patients was held (JLIS - 12, REM - 10, LT - 14) and 10 healthy people. Result. The main pathomorphological changes of skin in all groups were found in dermis: dense perivascular and perifollicular infiltration and deposit of mucin between collagen fibers. Deposits of mucin in papillary dermis were found between patients with JLIS, REM and LT in 10/12 (83%), 7/10 (70%) and 12/14 (86%) of cases, there were no mucin found in skin of healthy people 0/10 (0%) In all dermatosis the distribution of CD123 cells in lesional skin, in immunohistochemistry study, was corresponded clusters model of infiltrate - plasmacytoid DC concentrate in groups around vessels of superficial and profundus networks and perivascular. The comparative analysis of density and localization of perivascular infiltration, number of CD123-cells and their correspondence in dermis perivascular infiltrates didn’t reveal statistically significant differences between JLIS, REM and LT. Results. Our results allow us to consider JLIS and LT as identical decease, and REM as similar in clinical-pathomorphological features dermatosis.
Vestnik dermatologii i venerologii. 2015;91(6):41-49
pages 41-49 views

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