Vol 94, No 1 (2018)

EDITORIAL

A HUNDRED YEARS’ EXPERIENCE IN NATIONAL DERMATOVENEREOLOGY. STAGES OF DEVELOPMENT OF DERMATOVENEREOLOGICAL CARE FOR THE POPULATION (PART II)

Kubanova A.A., Martynov A.A., Vlasova A.V.

Abstract

The stages of the formation of a model for the organization of dermatovenereological care to the population of the Russian Federation during the period from 1917 to 2017 were analyzed.

Vestnik dermatologii i venerologii. 2018;94(1):14-26
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ORGANIZATION OF HEALTH CARE AND EPIDEMIOLOGY

DYNAMICS OF INCIDENCE OF SEXUALLY TRANSMITTED INFECTIONS IN THE EVALUATION OF THE EPIDEMIOLOGICAL PROCESS AND STATE OF HEALTH OF THE RUSSIAN FEDERATION POPULATION IN 2006–2016

Kubanova A.A., Kubanov A.A., Melekhina L.E.

Abstract

The paper presents the analysis of the incidence of sexually transmitted infections among the population  of the Russian Federation and among children age of 0–14 and adolescentsage of 15–17 in 2006–2016.

Vestnik dermatologii i venerologii. 2018;94(1):27-37
pages 27-37 views

ENTHESITIS AND PSORIATIC ONYCHOPATHY AS A FACTOR FOR PREDICTION OF PSORIATIC ARTHRITIS IN PSORIASIS

Sidorcika T.G., Linovs V.A., Radzina M.A., Rubins A.J., Rubins S.A.

Abstract

Psoriatic arthritis is a psoriasis-related spondyloarthropathy that occurs in 20–30 % of patients with psoriasis. Psoriatic arthritis affects the patient’s quality of life indicators and are more often associated with disabilities of working age than psoriasis skin form. Nail psoriasis has been proposed as a predictor for the development of psoriatic arthritis. The inflammation involving the entheses, called enthesitis, is an early inflammatory change seen in psoriatic arthritis, and nail changes appear to result from the close relationship between the nail and the enthesis of the distal interphalangeal extensor tendon, one of the main entheseal compartments affected in psoriatic arthritis. Various imaging studies have demonstrated that there is a considerable proportion of undiagnosed psoriatic arthritis among patients with psoriasis. Since early detection and treatment of psoriatic arthritis could, ultimately, allow the prevention of clinical and radiologic progression of the disease, there is the need to establish clinical indicators to detect this risk.

Vestnik dermatologii i venerologii. 2018;94(1):38-50
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THE PATHOGENETIC SUBSTANTIATION OF EFFICIENCY OF PHOTOPHERESIS IN ATYPICAL VARIANTS OF LICHEN PLANUS

Molochkova Y.V., Kil’dyushevskij A.V., Perlamutrov Y.N., Glazkov A.A., Molochkov V.N.

Abstract

Lichen planus (LP) is an autoimmune disorder which is characterized by long lasting, recurrent course of a disease and by poor response to treatment (including systemic corticosteroids and cytostatics). Cutaneous and mucosal LP may present in atypical forms, several can transform to cancer with statistical confidence. Earlier, we have confirmed high clinical efficacy of photopheresis — method of adoptive immunotherapy in treatment of patients with typical LP.

Target: research of clinical efficacy of photopheresis in complex trearment of atypical forms of cutaneous and mucosal LP.

Materials and methods. There had been carried out a study of the clinical and immunological efficacy in two groups of patients: patients receiving complex therapy, which includes photopheresis with routine therapy (delagil, doxycycline and topical corticosteroids (I groupe — 23 patients) and receiving complex therapy, which includes photopheresis with single injection of methotrexate in dose of 10 mg with routine therapy ( II groupe — 18 patients).

Results. In I group of patients immunological disorders were similar with results of earlier immunological studies in patients with lypical LP, among them increase in the number of CD16+-cells. In the II groupe immunological disorders were characterized by the rise of amount and activity of CD3+CD8+-lymphocytes. The high efficacy of Group I patient treatment was accompanied by the restoration of their tolerance to the skin antigenic structures, while maintaining the possibility for transendothelial migration of CD16 + cells. The effect of the treatment in Group II patients was also pronounced; however, due to the use of methotrexate, no normalization of the patients’ immune parameters was observed.

Conclusion. The data obtained confirms the high clinical efficacy of photopheresis in both groups of patients and its pathogenic validity in patients suffering from atypical lichen ruber planus.
Vestnik dermatologii i venerologii. 2018;94(1):51-59
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PREVALENCE FOR THE ATOPIC DERMATITIS DEVELOPMENT AT PRE-SCHOOL CHILDREN OF ALTAI KRAI

Shahova N.V., Kamaltynova E.M., Lobanov Y.F., Ardatova T.S.

Abstract

Aim of research: to evaluate the prevalence of atopic dermatitis at 3–6-year-old children by applying russified version of ISAAC questionnaire (International Study of Asthma and Allergies in Childhood) and to determine risk factors.

Materials and Methods. Cross-section research was carried out in five places of Altai Territory (2015–2016). The prevalence of AD was determined with the help of the russified ISAAC Manual filled in by parents of the 3–5-year-old children. The ISAAC definition for current atopic dermatitis (cAD) was used in studies. Patient considered suffering from cAD if respondents’ parents pointed «YES»  on three questions: «Have you ever had an itchy rash which was coming and going for at least six months?», «Have you had this itchy rash at any time in the last 12 months?», «Has this itchy rash at any time affected any of the following places: the folds of the elbows, behind the knees, under the buttocks, or around the neck, ears or eyes?».

Results. The research covered 3205 children of 3–6-year-old age. The prevalence of cAD was 12.3 % (n = 393). Medically confirmed diagnosis of AD was stated only at 7.9 % (n = 254) from 393 children. It was established in logistic-regression analysis that burdened familial allergologic history increases 4,6 times the risk of the cAD development at preschool age (OR = 4.62; 95 % CI = 3.69–5.77; p < 0,01). Little duration of breastfeeding (less than six months) increases the risk of cAD development 1,6 times (OR = 1.62; 95 % CI = 1.26–2.09; p < 0.05. The prematurity, tobacco smoking at parents or the contact with pets on the first year age were not found to enhance the risk of cAD development at preschool children.

Conclusion. The cAD prevalence markedly exceeds the rates of the medically confirmed diagnoses. The burdened familial history of allergic diseases and little duration of breastfeeding enhance the risk of cAD development at preschool age.

Vestnik dermatologii i venerologii. 2018;94(1):60-66
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GUIDELINES FOR PRACTITIONERS

THERAPY OF SKIN VASCULAR MALFORMATIONS USING COPPER VAPOR LASER AND PULSED DYE LASER

Klyuchareva S.V., Ponomarev I.V., Pushkareva A.E.

Abstract

Aim. Comparison of effectiveness of the application of copper vapor laser (CVL) and pulsed dye laser (PDL) in clinical practice. Development of choice criteria of the more effective method of treatment.

Materials and methods. The clinical data using CVL and PDL in the treatment of skin vascular malformations are presented. The treatment gave good results in removing of dysplastic skin vessels in 2 and 6 months. The treatment was not painful, and patients did not need general and local anesthesia. The results were presented concerning computer modeling of selective heating of vessels in tissue with CVL and PDL radiation. These results allowed to determine the depth of location and dimensions of vessels for selective and secure removing and the safe dosage ranges were found.

Results. On the base of the calculated data, one could conclude that the mode of heating of dysplastic vessels with micropulse series of CVL is more safe and effective than the mode of powerful short pulses in the case of PDL.

Vestnik dermatologii i venerologii. 2018;94(1):67-77
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CLINICAL CASE REPORTS

LATENT NEUROSYPHILIS — CAUSE OF DEATH

Vislobokov A.V., Zhuchkov S.A., Khmel’nickij R.A.

Abstract

The article describes a rare case of a manifest late neurosyphilis with a fatal outcome. Literature data on the features of the clinical course of neurosyphilis and its pathomorphological pattern are given. The results of a laboratory examination, including a histological examination, confirming the syphilitic lesion of the nervous system in this clinical observation are presented.

Vestnik dermatologii i venerologii. 2018;94(1):78-84
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SECONDARY SKIN SYPHILIS AND MUCOUS MEMBRANES AT ELEVEN-MONTHLY PATIENT

Koshkin S.V., Evseeva A.L., Ryabova V.V., Kovrova O.S.

Abstract

The current article analyzes a clinical case of insontium syphilis (secondary syphilis) in a 11-month patient. Attention is paid to household path of transmission of syphilis from parents to their child. Problems of differential diagnosis for clinical evidence of secondary acquired syphilis and congenital syphilis were analyzed.

Vestnik dermatologii i venerologii. 2018;94(1):85-90
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BENIGN LYMPHANGIOENDOTHELIOMA

Patrushev A.V., Belousova I.E., Gorislavskaya T.A., Suharev A.V., Samtsov A.V.

Abstract

The authors describe modern data relating to the definition, clinical, pathological and immunohistochemical features of a rare vascular tumor — benign lymphangioendothelioma. The problems of differential diagnosis with Kaposi’s sarcoma and angiosarcoma are discussed. This is the first description of this tumorin domestic literature.

Vestnik dermatologii i venerologii. 2018;94(1):91-96
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EXPERIENCE OF COMBINED APPLICATION OF METHYLPREDNISOLONE ACEPONATE AND MOLETOLO COSMETICS STEROIDSANDVIAGRAJY IN THE TREATMENT OF DERMATOSES

Orlov E.V., Konnov P.E., Arsenieva A.A.

Abstract

Skin diseases of non-infectious etiology, such as allergic contact dermatitis, atopic dermatitis, eczema  and chronic actinic dermatitis have a significant impact on the quality of patient’s life, greatly reducing it. The most important place in the therapy of these diseases is found in topical glucocorticosteroids in combination with competent basic therapy.

The aim of the study was to evaluate the clinical efficacy, safety profile, and tolerability of an external corticosteroid drug with a combination composition: methylprednisolone aceponate 0.1 % + urea 2 % (Komfoderm M2) in combination with dextpanthenol, allantoin and Shea butter (Dexpan plus cream) in dermatological practice in the treatment of eczematous process.

Materials and methods. 48 patients, from 18 to 58 years old with mild to middle-severe eczematous process, were under observation, including 16 with allergic contact dermatitis, 14 patients with atopic dermatitis and 10 patients with eczema brushes, and 8 people with actinic dermatitis. Cream Komfoderm M2 was applied to the affected skin areas once a day in combination with cream Dexpan plus as standard therapy and emollient cosmetic. We investigated the parameters of the DLQI questionnaire “Dermatological Quality of Life Index” .

Results As a result of the conducted observational study, data were obtained on the high effectiveness of therapy with the combined use of the drug Komfoderm M2 and Dexpan plus. An excellent evaluation of the efficacy of the scheme used was found in 37 (77 %) patients, a good one in 9 (18,8 %) and 2 (4.2 %) patients had a satisfactory result.

Conclusions. This clinical study proves the high efficacy, safety and tolerability of the drugs — Cream with 0.1 % MPA and urea 2 % (Komfoderm M2) in combination with a cream containing dexpanthenol, allantonoin and Shea butter (Dexpan plus) in the treatment of eczematous process.

Vestnik dermatologii i venerologii. 2018;94(1):97-102
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Соколовскому Евгению Владилавовичу -- 60 лет

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Abstract

Статья посвящена 60-летию педагогической, научной и лечебной деятельности Евгения Владиславовича Соколовского - доктора медицинских наук, профессора, заведующего кафедрой дерматовенерологии с клиникой ПСПбГМУ им. акад. И.П. Павлова
Vestnik dermatologii i venerologii. 2018;94(1):
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