Vol 91, No 3 (2015)

Rosacea: prevalence, pathogenesis, particular features of clinical manifestations

Kubanova A.A., Makhakova Y.B.

Abstract

This literature review examines principal aspects of rosacea prevalence in the Russian Federation and abroad, shows present-day opinions about the pathogenesis and histological picture of rosacea and presents actual classification and a number of key clinical forms of the disease.
Vestnik dermatologii i venerologii. 2015;91(3):36-45
pages 36-45 views

Medical cell technologies for treatment of patients suffering from recessive dystrophic epidermolysis bullosa. Method of intracutaneous administration of fibroblasts

Albanova V.I., Karamova A.E., Chikin V.V., Mineyeva A.A.

Abstract

Recessive dystrophic epidermolysis bullosa (RDEB) is a severe inherited disease developing due to genetic abnormalities in the synthesis of Type VII collagen by fibroblasts. A low production rate of Type VII collagen and abnormalities related to the formation of anchoring fibrils weaken the epidermis and derma adhesion strength, which results in the formation of blisters or erosions in case of any mechanical injury. Fibroblasts and keratinocytes belong to the key sources of Type VII collagen in the skin. Application of allogeneic fibroblasts is a promising cell technique for treating RDEB patients. The therapeutic effect of fibroblasts intradermal administration is stipulated by high stability of newly synthesized Type VII collagen and its ability to form anchoring fibrils in the area of the dermoepidermal junction. According to experimental and clinical studies, it is possible to boost the content of Type VII collagen in the dermoepidermal junction area and heal long-term skin defects in RDEB patients by means of intradermal administration of allogeneic fibroblasts.
Vestnik dermatologii i venerologii. 2015;91(3):46-53
pages 46-53 views

Role of peptide growth factors in the rhythm of change hair

Kubanov A.A., Gallyamova Y.A., Selezneva O.A.

Abstract

The article presents current data on the role growth factors play in hair physiology. Based on a review of literature, the authors described the role growth factors play for initiating, suppressing the growth and differentiating hair follicles. According to them, each morphologic development stage of hair follicles is characterized by its own factor expression pattern. Referring to experimental and clinical studies, the authors describe the role some growth factors play for mechanisms promoting the development of androgynous and focal alopecia.
Vestnik dermatologii i venerologii. 2015;91(3):54-61
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Using platelet-enriched autologous plasma for treatment of non-scarring alopecias (androgenetic and circumscribed alopecia)

Mareyeva A.N., Kondrakhina I.N., Abuladze M.G.

Abstract

The article presents literature data on the efficacy of using platelet-enriched autologous plasma for treatment of non-scarring alopecias (androgenetic and circumscribed alopecia).
Vestnik dermatologii i venerologii. 2015;91(3):62-66
pages 62-66 views

ORGANIZATION OF HEALTH CARE AND EPIDEMIOLOGY

Russian register of patients suffering from chronic skin diseases

Kubanov A.A., Almazova A.A., Bogdanova Y.V.

Abstract

The article provides a review of regulatory documents providing for the establishment of a universal governmental healthcare information system in the Russian Federation, describes the key goals and tasks for the register of patients with chronic skin disorders and characterizes different types of registries and their use.
Vestnik dermatologii i venerologii. 2015;91(3):16-20
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Prevalence of hereditary epidermolysis bullosa in the Russian Federation

Kubanov A.A., Albanova V.I., Karamova A.E., Chikin V.V., Melekhina L.Y., Bogdanova Y.V.

Abstract

Goal. To study the prevalence of hereditary epidermolysis bullosa (HEB) in the Russian Federation. Materials and methods. The data on the number of HEB patients by subjects of the Russian Federation as well as their age and disease type were obtained based on questionnaires. The questionnaires were sent to dermatovenerology healthcare institutions from 85 subjects of the Russian Federation. The HEB prevalence rates in the subjects of the Russian Federation were calculated as the ratio of the number of HEB patients in the subject of the Russian Federation to the population size in the subject per million residents. Results. Information about 438 HEB patients (210 female and 228 male) aged 0-66 was collected in 70 subjects of the Russian Federation as of January 1, 2015. The disease type was specified for 139 patients (86 patients with common HEB, 50 patients with dystrophic HEB and 3 patients with the borderline form of HEB). No details about the disease type were provided for 299 patients (68.26%). The HEB prevalence rate in the subjects of the Russian Federation varies from 0 to 19.73 cases per million residents. Conclusion. These data on the HEB prevalence rate in 70 subjects of the Russian Federation are comparable to the data specified in literature sources providing information on the HEB prevalence rate in some foreign states. The data represent the first step to the development of clinical recommendations concerning HEB management and establishment of a register of in the Russian Federation.
Vestnik dermatologii i venerologii. 2015;91(3):21-30
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Prevalence of localized scleroderma in the Krasnodar territory

Tlish M.M., Sorokina N.V.

Abstract

The authors conducted a study of particular features of the course of localized scleroderma in the south of Russia (Krasnodar territory). 65 case histories were analyzed. Women suffered from the disease 2.8 times more often than men; one half of the sample (55.4%) included patients aged 35-55; the disease duration of over a year prevailed (69.8%); the disease occurred against the background of an endocrine pathology in one third of all cases; one third of all women developed the disease during the postmenopausal period. Plaque scleroderma (56.9%), white spot disease (von Zumbusch psoriasis) (16.9%) and idiopathic atrophoderma of Pasini and Pierini (12.3%) belonged to the key clinical forms. The average number of lesions was 2.4 ± 1.2 while almost a half of the patients (47.7%) had three or more lesions. The clinical manifestations localized mostly on the back (46.5%) and stomach (34.9%).
Vestnik dermatologii i venerologii. 2015;91(3):31-35
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GUIDELINES FOR PRACTITIONERS

Clinical application of gancyclovir in the complex treatment of the different forms of true acantholytic pemphigus

Baltabaev M.K., Baltabaev A.M.

Abstract

Short summary and results of the own clinical observations on efficacy of developed complex method on the treatment of true acantholytic pemphigus composed of traditional immunosuppressive therapy and antiviral remedy - gancyclovir are presented. The etiology of herpesvirus infection had been discussed in the pathogenesis of the disease.
Vestnik dermatologii i venerologii. 2015;91(3):124-130
pages 124-130 views

Steroidophobia in dermatology - contemporary problem of the past

Dvoryankova E.V.

Abstract

Topical steroids are the first-line drugs for the treatment of the majority of dermatological diseases. Currently, however, often we have to deal with steroidophobia both among patients and doctors. The problem has been actively studied since steroidophobia can significantly reduce the quality of the treatment. At the same time, with the use of modern topical steroids, such as Advantan, steroidophobia has no grounds due to the high level of safety under normal use of drugs.
Vestnik dermatologii i venerologii. 2015;91(3):131-134
pages 131-134 views

A comparative analysis of the efficacy of a combined topical therapy in patients suffering from mild to moderate papulopustular acne

Kondratiyeva Y.S., Shepileva T.N., Kokina O.A., Subbotin Y.A.

Abstract

The goal of this study was to compare the efficacy and safety of Azelic (15% gel of azelaic acid), 1% Clindamycin gel and 0.1% Adapalene gel as a complex therapy in patients suffering from mild to moderate acne. Materials and methods. An open-label comparative study involving 40 patients suffering from mild to moderate papulopustular acne. The study was based on the medical history, a questionnaire form, physical examination results, assessment of morphological and functional skin parameters and dynamics of the life quality index (DLQI). Key findings and conclusions. Positive dynamics of the skin process was observed by the end of Week 6 of the treatment depending on the combination treatment type. The administration of Azelic gel resulted in an increased moisture level of the skin and reduced sebometry indices, skin relief intensity and pigmentation level.
Vestnik dermatologii i venerologii. 2015;91(3):135-140
pages 135-140 views

Treatment of patients with severe and moderate acne

Perlamutrov Y.N., Olhovskaya K.B.

Abstract

Objective. To determine the effectiveness and safety ot the drug Sotret when treating patients with severe or moderate acne resistant to other therapies. Material and methods. The study included 30 people. Determining the severity ot acne was conducted using the DIA, the assessment ot quality ot lite - the scale ot CADI. In the acne treatment patients were using the drug Sotret as monotherapy. Results of the study. Sortret drug therapy contributed to erase the severe and rapid dynamics ot indicators DIA, the tormation ot clinical remission was reported in 93.33% ot patients. Adverse events were dose dependent and primarily recorded in the tirst three months ot the treatment. Use ot the drug by patients erase acne contributed to improving the quality ot lite at an average degree ot severity ot the disease at 93.53%, with a heavy - at 82.74%. Conclusion. The clinical etticacy expressed Sotret demonstrates its wide application
Vestnik dermatologii i venerologii. 2015;91(3):141-146
pages 141-146 views

A combined topical therapy of chronic dermatoses

Filimonkova N.N., Bakhlykova! Y.A.

Abstract

The article analyzes literature sources on the etticacy ot the topical glucocorticosteroid therapy ot chronic dermatoses. Special attention is paid to evidence-based studies ot the etticacy and satety ot a combination therapy ot complicated chronic dermatoses using the Akriderm GK drug.
Vestnik dermatologii i venerologii. 2015;91(3):147-152
pages 147-152 views

Naftifine hydrochloride in treatment of foot mycosis complicated with a bacterial infection and significant inflammatory reaction

Kotrekhova L.P.

Abstract

Goal of the study. To compare the etticacy ot nattitine hydrochloride (Exoderil® cream) and combination cream comprising betamethasone dipropionate, clotrimazole and gentamicin sultate in treatment ot toot mycosis complicated with a bacterial intection and signiticant intlammatory reaction. Materials and methods. A single-center, prospective, randomized, open-label comparative study involved 75 patients aged 23-80 suttering trom toot mycosis complicated with a bacterial intection and signiticant intlammatory reaction. The patients were randomized in two groups. The tirst group comprised 36 patients receiving nattitine hydrochloride while the second one included 39 patients treated with a combination drug comprising betamethasone, clotrimazole and gentamicin. Results. The anti-bacterial etticacy ot nattitine and combination drug comprising betamethasone, clotrimazole and gentamicin was comparable. Complete sanitation ot the bacterial intection was achieved in 94% ot the patients in both groups. The antimycotic etticacy ot nattitine (Exoderil® cream) was reliably higher than that ot the three-component drug to amount to 97% and 82%, respectively (p = 0.03). Complete recovery was achieved in 92% ot the patients treated with nattitine hydrochloride cream and 82% ot the patients treated with the three-component drug (p = 0.22). Conclusion. Exoderil® cream (active substance: nattitine) is a highly etticient drug tor treatment ot ditterent clinical torms ot skin mycosis including those accompanied by a signiticant intlammatory reaction and/or concomitant bacterial intection.
Vestnik dermatologii i venerologii. 2015;91(3):153-160
pages 153-160 views

Natamycin - antimycotic of polyene macrolides class with unusual properties

Malova I.O., Petrunin D.D.

Abstract

In the current literature review issues regarding physicochemical peculiarities, mechanism ot action and satety aspects ot polyene macrolides class compound natamycin are enlightened along with the extensive clinical data upon the use ot pharmaceuticals containing this active ingredient.
Vestnik dermatologii i venerologii. 2015;91(3):161-184
pages 161-184 views

The cutaneous manifistation of Lyme Borreliosis: primary borrelial lymphocytoma and surrounding secondary erythema chronicum migrans

Sokolovskiy E.V., Gorislavskaia T.A., Mikheev G.N.

Abstract

The authors describe a rare clinical observation of the cutaneous manifistation of Lyme Borreliosis: primary borrelial lymphocytoma and surrounding secondary erythema chronicum migrans. The review of clinical features, histology, is also present.
Vestnik dermatologii i venerologii. 2015;91(3):104-108
pages 104-108 views

Epidermolysis bullosa acquisita

Chikin V.V., Znamenskaya L.F., Nefedova M.A., Charikov V.A.

Abstract

The article describes present-day information on the pathogenesis, clinical picture, treatment and differential diagnostics of epidermolysis bullosa acquisita, an autoimmune skin disease caused by the production of anti-Type VII collagen autoantibodies and manifested mainly by subepidermal blisters and erosions. The authors present the results of a case study of a rare form of epidermolysis bullosa - epidermolysis bullosa acquisita in a male patient aged 53. A combined therapy with peroral prednisolone and subcutaneous injections of methotrexate had a positive effect in the form of epithelialization of most of the erosions.
Vestnik dermatologii i venerologii. 2015;91(3):109-118
pages 109-118 views

Case studies of skin melanoma

Kozlova A.V., Shumbasov M.A., Rybnikov Y.A., Goldberg S.M., Mikitin O.S., Kazakov V.M., Semenov E.V., Ruksha T.G.

Abstract

Skin melanoma is a malignant tumor originating in the cells of the melanocytic system, which is characterized by an aggressive clinical course, significant metastatic potential and unfavorable prognosis. These features of the tumor stipulate the need to improve measures to optimize early diagnosis of tumors. The article presents cases of pigmented skin melanoma to demonstrate the variability of clinical manifestations of this tumor requiring dermatologist skills in the differential diagnostics of neoplasms.
Vestnik dermatologii i venerologii. 2015;91(3):119-123
pages 119-123 views

Diagnostic value of the confocal laser scanning microscopy in vivo

Kubanova A.A., Kubanov A.A., Smolyannikova V.A., Gribanov N.V., Makhakova Y.B.

Abstract

The confocal laser scanning microscopy in vivo is a promising study method to visualize cell structures of epidermis and papillary dermis without affecting the skin integrity, which provides for a resolution and contrast similar to those characteristic of the classical histology examination. Goal. To assess the confocal laser scanning microscopy in vivo (CLSM) technique for diagnosing actinic keratosis, psoriasis vulgaris and rosacea vs. the classical histology examination. Study materials. The article describes the results obtained by using the confocal laser scanning microscopy in vivo technique vs. the histology examination in 10 patients with erythematous actinic keratosis, 10 patients with extensive psoriasis and 10 patients with erythematous and papulous rosacea. Results. The article describes diagnostically significant signs of the diseases detected by using the confocal laser scanning microscopy in vivo as well as the potential of this method in terms of diagnosing inflammatory skin diseases.
Vestnik dermatologii i venerologii. 2015;91(3):67-74
pages 67-74 views

Complex non-invasive methods of investigation of the pathophysiological processes in the skin of patients with rosacea

Kubanova A.A., Makhakova Y.B., Krupatkin A.I.

Abstract

Goal. To develop a complex method for diagnosing rosacea by using non-invasive examination methods and study their application for assessing the treatment efficacy. Materials and methods. The authors conducted a study of 46 rosacea patients (15 male and 31 female) including 29 patients with erythematous and 17 ones with papulous subtypes of the disease. The patients underwent treatment using IPL (5-8 treatment sessions). The condition of skin vessels was assessed prior to and after treatment using dermatoscopy, laser Doppler flowmetry (LDF) and confocal laser scanning microscopy in vivo (CLSM). Results. The authors developed a complex method for diagnosing rosacea using dermatoscopy, CLSM and LDF techniques prior to and after treatment. As many as 46 patients suffering from erythematous and papulous subtypes of rosacea underwent treatment using broadband pulse light emission. The clinical efficacy of such treatment was assessed by using a set of non-invasive examination methods, and terms for new treatment courses were forecasted. Conclusion. A combination of different enables real-time assessment of the dynamics of the pathological process in the skin of patients suffering from rosacea and makes it possible to get unbiased information about the treatment efficacy and forecast terms for new treatment courses.
Vestnik dermatologii i venerologii. 2015;91(3):75-86
pages 75-86 views

Dynamics of expression rates of growth factor proteins in psoriatic patients receiving a phototherapy

Chikin V.V., Zhilova M.B., Smolyannikova V.A., Nefedova M.A.

Abstract

Goal. To study the dynamics of expression rates of growth factor proteins in psoriatic patients receiving the PUVA therapy. Materials and methods. The authors conducted a study of 30 patients with psoriasis vulgaris treated with the PUVA therapy. The psoriasis severity and extent of itching were assessed prior to and after the treatment by the PASI index and visual analogue scale, respectively. The expression of semaphorin 3A, amphiregulin, nerve growth factor and PGP 9.5 protein (a nerve fiber marker) in the skin was assessed by the indirect immunofluorescence method. The expression of PGP 9.5 protein was used to assess the quantity and mean length as well as average and total fluorescence intensity of nerve fibers. Results. An increased expression of amphiregulin and nerve growth factor as well as increase in the quantity, mean length and average and total fluorescence intensity of nerve fibers were revealed in the epidermis of psoriatic patients. Following a course of the PUVA therapy, a decrease in the PASI index and extent of itching, reduced expression of amphiregulin and nerve growth factor as well as reduced quantity, mean length and average and total fluorescence intensity of nerve fibers in the epidermis were observed. Direct correlation dependence between the extent of itching, amphiregulin and nerve growth factor expression level and quantity and length of nerve fibers in the epidermis was discovered. Direct correlation dependence between the amphiregulin and nerve growth factor expression level, and average length of nerve fibers in the epidermis was discovered. Conclusion. The itching intensity in psoriatic patients receiving the PUVA therapy is reduced due to the decreased skin expression of the nerve growth factor and amphiregulin.
Vestnik dermatologii i venerologii. 2015;91(3):87-95
pages 87-95 views

Clinical and morphological diagnostics of skin manifestations in case of graft-versus-host disease

Krivolapova A.Y., Smirnova I.O., Lisukova Y.V., Moiseyev I.S., Belousova I.E., Baikov V.V.

Abstract

The graft-versus-host disease is a life-threatening complication of allogeneic bone marrow transplantation, which demands fast and reliable diagnostics. Goal. To study clinical features of the graft-versus-host disease as well as differential and diagnostic value of histological and immunohistochemical signs in skin biopsy samples in case of graft-versus-host disease (GvHD). Materials and methods. The authors made a comparative assessment of clinical data available for patients suffering from acute GvHD (50 patients) and toxic dermatitis (10 patients). Skin biopsy samples taken from patients from both groups underwent postmortem and immunohistochemistry examinations: the drugs were stained with hematoxylin and eosin as well as by using anti-CD3, CD20, CD4, CD8, FOXP3, CD56, CD1a and CD 68 antibodies. Results. Based on the results of clinical data assessments, no significant differences in the groups were revealed. The morphological examination revealed that the number of eosinophils, CD8+, CD1a+, CD3+ and FOXP3+ cells and share of FOXP3+ cells among Т lymphocytes was higher in the group with toxic dermatitis. Conclusion. An integrated assessment of clinical data and morphological examination results accompanied by the analysis of the population composition of the infiltrate is needed to diagnose the acute GvHD.
Vestnik dermatologii i venerologii. 2015;91(3):96-103
pages 96-103 views

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