Vol 86, No 4 (2010)

Timely and high-quality diagnostics of IgE-mediated sensibilization can greatly optimize the therapy for children suffering from atopic dermatitis. In practice, physicians often come across problems of selection of the rational method for examination and interpretation of obtained results. This review reflects the current approaches to this problem.

The authors give the results of immunohistochemistry studies of the skin of 16 healthy volunteers and 16 patients suffering from vulgar vitiligo with the determination of the contents of immature (CD1a+) and mature (CD83+) subpopulations of dendritic cells (DCs) as well as CD4+ and CD8+ lymphocytes in the epidermis and perivascular infiltrates of the derma. They revealed an increased quantity of CD1a+ and CD83+ DCs in areas of depigmented, peripheral and perifocal normally pigmented skin of vitiligo foci. DCs with the CD1a+ phenotype were revealed both in the epidermis and in the derma while DCs with the CD83+ phenotype were revealed in the derma only. A higher quantity of CD4+ and CD8+ lymphocytes than in healthy volunteers was also revealed along with the increased contents of DCs in all three areas of vitiligo foci. The authors established a strong correlation between the quantity of CD83+ DCs and CD4+ lymphocytes in the depigmentation zone (r=0.84; Р<0.001). The data obtained prove the involvement of CD1a+ and CD83+ DCs in the pathogenesis of vitiligo and their participation in the initiation of T-cell response in the affection foci.

The prevalence and genetic origin of acne explain the urgency of searching for new dermatosis treatment methods. The occurrence of acne in women is stipulated by hyperandrogynous conditions and is often accompanied with insulin resistance. The administration of Metformin in the complex therapy of acne in women with insulin resistance contributes to considerable improvement of the clinical course of dermatosis and achievement of remission for a greater number of patients.

The article is written in the form of a discussion. It examines clinical recommendations regarding sexually transmitted infections (except for syphilis) being the forerunner of the standard published for management of patients from this category. The authors assess the clinical recommendations in a positive way. They also express their request about introducing certain amendments and clarifications in the standard at the time of its publication.

The authors present the results of studying clinical manifestations of cheilitis in 143 children suffering from atopic dermatitis. The severe stage of cheilitis was observed in 42.7% of children, the medium to severe stage - in 35.7%, the mild stage - in 21.6%. The authors revealed more frequent development of episodes of bronchial obstruction (55.3%) and recurrent respiratory diseases (69.2%) in such children. They also revealed defects of barrier, anticolonial and microbicide functions of the secretory immunity of the patients oral cavity. The administration of Imudon in the complex therapy produced a good therapeutic effect in 77.4% of children and reduced the frequency of development of acute respiratory diseases.

The article presents the results of a study of the clinical efficacy of the administration of Phosphogliv for psoriasis and its effect on the functional and biochemical parameters as well as patients quality of life. The authors established that the administration of Phosphogliv results in a considerable improvement of the course of extensive psoriasis and reduction in the activity of the inflammatory process contributing to the normalization of the lipid composition of the blood serum at the expense of the lipotropic and membrane stabilizing action.

The article examines stages of development for the V.M. Tarnovsky medical research association of dermatovenerologists being the first in Europe and assess the contribution made by its members to the development of Russian dermatovenerology

The article presents data on the scientific contributions of Professor IF Zeleneva in the development of national dermatology and venereology.