Vol 86, No 6 (2010)

Decree of the Russian Federation Ministry of Public Healthand Social Development No. 1099 of Dec 03, 2010 Onapproval of statute of federal state institution NationalResearch Center of Dermatovenerology and Cosmetology,as amended
 
Abstract
Vestnik dermatologii i venerologii. 2010;86(6):4-6
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Inhibitors of tumor necrosis factor-alpha for treatment ofpsoriatic patients
 
Abstract
The article describes current concepts of the role of cytokines in the pathogenesis of inflammatory diseases. The authors describe the biological action of tumor necrosis factor-alpha and its soluble receptors on body cells. They also provide data on the role of tumor necrosis factor-alpha in the formation of skin and joint inflammatory affections at psoriasis. The authors substantiate treatment of medium to severe forms of psoriasis with biological gene-engineered anti-cytokine drugs, and provide and their comparative characteristics.
Vestnik dermatologii i venerologii. 2010;86(6):7-15
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Current approaches to diagnostics of mycosis fungoides
 
Abstract
The authors describe strong and weak sides of current methods for diagnostics of mycosis fungoides. Diagnostics of mycosis fungoides is mainly based on the clinical presentation of this disease, which is a significant problem for a dermatovenerologist, especially at early stages of the disease when rashes are of different types. Laboratory methods used to confirm the diagnosis are microscopic examination and immunophenotypic analysis of skin biopsy samples from the affected region as well as determination of clonality of T-lymphocytes in the skin using the PCR method.
Vestnik dermatologii i venerologii. 2010;86(6):16-22
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Tacrolimus: 10 years of successful clinical application
 
Abstract
Tacrolimus (FK506) is the first drug from the new class of drugs - calcineurin inhibitors. It has a great potential and can change the current approaches to treatment of different dermatoses. Topical forms of Tacrolimus are activated due to the effect on T-lymphocyte signal transduction, and they also inhibit gene transcription. As a result, the T-cell response to antigens is alleviated. Percutaneous absorption of Tacrolimus in affection foci is higher than in healthy skin. Due to this a smaller amount of the drug is absorbed by the skin as long as the skin is healed. Systemic absorption of Tacrolimus is low in the course of treatment. The maximum clinical experience has been gained in the field of applying Tacrolimus for treatment of atopic dermatitis. In a number of clinical studies, 0.03-0.3% Tacrolimus ointment efficiently reduced the severity of symptoms and course of atopic dermatitis in adults and children. Moreover, topical treatment with Tacrolimus did not involve any substantial toxic effects. The patients most often complained of local irritations in the area where the ointment was applied, which were transient by nature and did not demand the drug withdrawal. Today Tacrolimus is a valuable and safer alternative to glucocorticosteroids for treatment of atopic dermatitis. It can also be used for treating other dermatoses, which demands additional all-round examination.
Vestnik dermatologii i venerologii. 2010;86(6):23-38
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Immune and genetic mechanisms of infertility andreproductive function disorders associated with humanurogenital chlamydial infection
 
Abstract
This review covers current concepts of immune and genetic mechanisms of infertility associated with human urogenital chlamydial infection. It describes studies of individual polymorphisms of genes coding cytokines and other immune system mediators. It also presents the results of studies aimed at searching for genetic predisposition to the development of complications resulting in human reproductive function disorders caused by past urogenital chlamydial infections.
Vestnik dermatologii i venerologii. 2010;86(6):39-45
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Efficacy of complex treatment for patients withcircumscribed alopecia using the biofeedback method
 
Abstract
The authors assessed the efficacy of complex treatment for patients with circumscribed alopecia using the biological feedback method. As compared to the drug treatment, the complex method makes it possible to improve the treatment results and increase the duration of remissions
Vestnik dermatologii i venerologii. 2010;86(6):46-50
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Intestinal helminth and protozoan infections in patients withchronic dermatoses
 
Abstract
According to the statistics reports for 2005-2008, a reliable reduction in the intensive indices of lambliasis incidence rate in the Sverdlovsk region as well as tendency towards a reduction in opisthorchosis and enterobiasis incidence rate was revealed. An examination of 262 patients in the clinics of FGU UrNIIDViI revealed that the incidence of helminthic and protozoal invasions in psoriatic patients was 44.1% while the incidence of allergic dermatoses was 32.3%. Blastocysts, intestinal amoebas, seatworms as well as opisthorchid flukes in case of psoriasis dominated in terms of incidence. High prevalence of seatworms in adolescent males and women of childbearing potential was discovered.
Vestnik dermatologii i venerologii. 2010;86(6):51-57
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Clinical and immunological characteristic of vulvovaginalcandidosis in women suffering from pulmonary tuberculosis
 
Abstract
The article describes results of a study involving 346 women who received a combination therapy with antibiotics for pulmonary tuberculosis for more than a year. Vulvovaginal candidosis was revealed in 158 (45.7 %) of them. Candida аlbicans were the prevalent pathogen: it was found in 103 (77.4%) patients. The article describes complaints, clinical manifestations and changes in the immunology indices of the vaginal secretion in this group of patients.
Vestnik dermatologii i venerologii. 2010;86(6):58-64
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Combination treatment of psoriasis patients with kartalinointment and ehf therapy
 
Abstract
The author assessed clinical efficacy of a combination treatment of psoriasis patients with EHF therapy and Kartalin ointment. Clinical efficacy of combination treatment of psoriasis patients using the Kartalin ointment and EHF therapy was assessed in 153 patients suffering from mild to moderate psoriasis. All of the subjects were divided into three groups. The first group comprised 30 people receiving conventional treatment (vitamins, hyposensitization drugs and indifferent ointments) and the second group comprised 50 patients receiving conventional treatment in a combination with EHF therapy. The third group comprised 73 patients receiving EHF therapy in a combination with Kartalin ointment and conventional treatment. It was established that extremely high frequency (EHF) radiation (4.7-5.1 mm) in a combination with Kartalin ointment had the most evident effect on the clinical and morphological indices in psoriatic patients at the progression stage of the disease accompanied by the decrease in PASI by 67.2%.
Vestnik dermatologii i venerologii. 2010;86(6):65-67
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A case study of Mibellis disease with unilateral lesion foci
 
Abstract
A case study of the classical form of a rare form of inherited dermatosis, Mibellis disease, featuring unilateral position of the foci in a child aged 3. A histological examination revealed aggregations of parakeratotic cells in epidermis being characteristic of Mibellis disease.
Vestnik dermatologii i venerologii. 2010;86(6):68-70
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Clinical and morphological features of the hypertrophic formof lichen acuminatus
 
Abstract
The article presents information from published sources about clinical and morphological features and treatment of the hypertrophic form of lichen acuminatus. The authors also describe the results of their own observations for two patients with this form of dermatosis. The patients were diagnosed based on the complex assessment of clinical manifestations, course of the disease and histological examination of skin biopsy results.
Vestnik dermatologii i venerologii. 2010;86(6):71-76
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Possibility to use Ademetionine for the treatment of psoriaticpatients with a pathology of the hepatobiliary system
 
Abstract
The endogenous intoxication syndrome manifested in the form of excessive accumulation of low and mean molar mass substances in plasma and urine as well as increased blood plasma concentrations of malonic dialdehyde against the background of reduced alpha-tocopherol was revealed in psoriatic patients with the concomitant hepatobiliary system pathology. Application of Ademetionine in the dose of 800 mg per day for 15 days as a part of the complex therapy for such patients as opposed to the patients receiving standard therapy resulted in reliable reduction in the severity of clinical manifestations of the disease and PASI value as well as decrease in the concentration of low and mean molecular mass substances in plasma and erythrocytes, reduction in the blood plasma malonic dialdehyde concentration and increase in alpha-tocopherol.
Vestnik dermatologii i venerologii. 2010;86(6):77-82
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Treatment of patients with different clinical forms of rosacea
 
Abstract
The latest information about etiology, pathogenesis, classifications, clinical manifestations and treatment of rosacea has been provided.
Vestnik dermatologii i venerologii. 2010;86(6):83-85
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Evaluation of clinical efficacy of treating patients sufferingfrom atopic dermatitis with drugs containing Aicida, anantiseptic stimulator of Dorogov
 
Abstract
The article presents the results of a study of efficacy of using Aicida, a cosmetic drug with such an active substance as ASD (Dorogovs antiseptic stimulator) in a liposomal form providing for the target delivery of the drug to deep skin tissues, for treatment of patients with atopic dermatitis. It also demonstrates high efficacy and good tolerance of the cosmetic product in patients with medium to severe forms of atopic dermatitis.
Vestnik dermatologii i venerologii. 2010;86(6):86-92
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External glucocorticosteroids: selection criteria in terms ofefficacy and safety
 
Abstract
The article describes mechanisms of action as well as indications and adverse effects of topical glucocorticosteroids. It examines the pharmacological and pharmacokinetic properties of fluticasone propionate, an efficient external glucocorticosteroid having a high safety level and good cosmetic properties. The data of controlled Russian and international studies of the efficacy and safety of fluticasone propionate for the treatment of psoriasis, atopic dermatitis and eczema.
Vestnik dermatologii i venerologii. 2010;86(6):93-100
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Etiology and treatment of circumscribed sclerodermarevisited
 
Abstract
There was a clinical and laboratory study of the efficacy of complex treatment with Longidaza, a Russian enzyme drug, in 30 patients suffering from circumscribed scleroderma. High efficacy of treatment for different clinical forms of circumscribed scleroderma using this method was proved. A positive effect of the complex therapy on the results of ultrasonic skin examination in the affection foci and individual blood immunology indices was revealed.
Vestnik dermatologii i venerologii. 2010;86(6):101-106
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Results of the study of Cinocap cream clinical efficacy andsafety
 
Abstract
There was a study of the efficacy and safety of a zinc pyrithione drug, Cinocap® cream, in 40 psoriasis patients. The therapeutic equivalence of the drug to the original drug, Skin-Cap® cream, was also assessed. Patients aged 18-65 were randomized into two groups: patients from the first group received a treatment with Cinocap® cream while patients from the second group were treated with Skin-Cap® cream for 45 days. It was proved that Cinocap® cream is an efficient drug for the treatment of psoriasis and is comparable to the original drug, Skin-Cap® cream, by its therapeutic effect and safety.
Vestnik dermatologii i venerologii. 2010;86(6):107-114
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Efficient application of external softening and moisturizingdrugs for the treatment of atopic dermatitis in children
 
Abstract
The article presents data confirming the efficacy of external application of Locobase Repair cream and Atoderm cream in a combination with hydrocortisone 17-butyrate 0.1% (Locoid ointment) in children aged from 6 months to 12 years suffering from moderate atopic dermatitis. The patients were followed up for a year. The treatment efficacy was estimated according to the dynamics of the SCORAD index and skin instrumental examination indices (corneometry, tewametry and pH-metry). The life quality in children younger than 5 years was estimated based on the Childrens Dermatology Life Quality Index (CDLQI). The external therapy mentioned above resulted in the decreased frequency of atopic dermatitis exacerbations, their reduced severity, increased duration of inter-recurrent periods and reduced need in topical corticosteroids.
Vestnik dermatologii i venerologii. 2010;86(6):115-123
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Analysis of the reproductive and somatic health indices inwomen with sexually transmitted diseases
 
Abstract
The reproductive and somatic health condition was studied in 60 women suffering from sexually transmitted diseases. It was established that a high rate of reproductive sphere pathologies (including related to STDs in the anamnesis) of the concomitant somatic pathology is developed in socially secure young patients suffering from STDs and intending to have a baby in the future. Efficacy of the complex therapy of mixed infections with Safocid, a combined drug, was demonstrated.
Vestnik dermatologii i venerologii. 2010;86(6):124-129
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Role of polymorphism of the androgen receptor gene andnon-random x chromosome inactivation in the pathogenesisof androgenic alopecia
 
Abstract
The article presents data on molecular and genetic studies of mechanisms of development of androgenic alopecia as well as correlation between polymorphism of the androgen receptor gene by the CAG repeat length in exon 1 and androgen-dependent diseases including alopecia.
Vestnik dermatologii i venerologii. 2010;86(6):130-134
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Skin barrier properties and basic care: innovations in theoryand practice
 
Abstract
The authors present data on skin barrier properties and basic care including care with the usage of Physiogel as a cosmetic product
Vestnik dermatologii i venerologii. 2010;86(6):135-140
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New drugs for mesotherapy. Bio preparations incosmetology - evolution or revolution?
 
Abstract
The authors describe lines of drugs developed on the basis of structurally modified hyaluronic acid. They demonstrate their effect on the synthesis of collagen fibers and state of intercellular matrix. They also present the results of studies of efficacy of using these drugs for correction of involutional skin changes.
Vestnik dermatologii i venerologii. 2010;86(6):141-145
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History of syphilis studies at the chair of skin and venerealdiseases, military medical academy, for its 140th anniversary
 
Abstract
The article examines stages of development for one of the first Russian chairs of syphilology and assess the contribution made by V.M. Tarnovsky, T.P. Pavlov, S.T. Pavlov and other employees to the development of syphilis studies.
Vestnik dermatologii i venerologii. 2010;86(6):146-149
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To the 60th anniversary
 
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Vestnik dermatologii i venerologii. 2010;86(6):150-151
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To the 80th anniversary
 
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Vestnik dermatologii i venerologii. 2010;86(6):152-153
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XI All Russian congress of dermatovenerologystsand cosmetologysts
 
Abstract
Vestnik dermatologii i venerologii. 2010;86(6):154-156
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