Vol 88, No 3 (2012)

Congress

Representation of the analysis of the restructuring of the resource base for specialized medical organizations with dermatovenerologic profile and procurement of the population with such kind of medical assistance.

Background papers on psoriasis epidemiology, pathogenesis and genetics are presented. Special attention is given to genetic factors of the aptitude to psoriasis development. Were analysed researches, dedicated to the genome-wide screening of associations of polymorphic genetic locus with psoriasis development. Obtained results allow to reveal pathogenic psoriasis mechanisms, to forecast the character of the clinical course of the disease, as well as the efficiency of therapy and forecast the risk of psoriasis origination at patient’s relatives.

Represents results of research, dedicated to the search of genetically determined factors of С. trachomatis virulence. Data of papers, studying features of С. trachomatis genetic variations was highlighted.

The immune response, developing with psoriasis relapse, starts from the concentration of activated myeloid dendrite cells, being the main source of the necrosis factor of α -tumor in the area of originating papula. Target: studies of the number of sub-populations of dendrite cells in skin of patients, suffering from psoriasis in different periods of the disease. Маterial and methods. Skin biopsy samples of 43 patients, suffering from psoriasis vulgaris and skin biopsy samples of 16 healthy people have been studied. The skin immunohistochemistry with use of anti-CD11c, CD83 and CD3 аntibodies was performed. Results. The number of CD11c+ and CD83+ dendrite cells in the skin of patients, suffering from psoriasis in the progressing period was 11,2 and 7,8 times more than in the skin of healthy individuals and 3,0 and 2,4 times more than at patients, suffering from psoriasis during remission accordingly. Opinions. In the skin of patients, suffering from psoriasis, during remission at the place of the delivered psoriatic papule the number of CD83+, CD11c+ dendrite cells and CD3+ lymphocytes exceeds its number in the healthy skin, and the ratio of these cells and its localization in the lesion focuses differ from the skin of healthy people.

The term of “isotopic response” was offered by R. Wolf and co-authors in 1995 and means the development of the new dermatosis at the place of already existing initial one, which has already regressed and is not directly referred to the first one. The article describes the essence of the phenomena and most important clinical cases. Such pathogenic mechanisms as viral, immunologic, vascular, neurogenic theory are being discussed, as well as the immunocompromised site concept. The commonality and the difference of the isotopic response and of the isomorphic Kobner’s phenomenon are being analyzed. Two clinical cases are provided.

Harlequin ichtyosis was observed at a girl, who managed to survive till 4 months age. Results of postmortem examination were presented. Diagnostic criteria were described, issues of prenatal diagnostics and treatment opportunities are being discussed.

Target. Studies of dynamics of species diversity and of abundance of Malassezia fungi, аs well as of pimple mites at the skin of patients, suffering from seborrheic dermatitis (SD) at the treatment with activated zinc pyrithione aerosol (ZPA). Маterial and methods. 60 patients with SD were examined. 2 groups were segregated: 1-st (n = 31) - patients with SD, receiving within 4 weeks the AZP therapy; 2-nd (n = 29) - patients with SD, not receiving local therapy. At the examination the gravity of symptoms, the dynamics of skin integument affection was assessed, the mycological skin analysis for Malassezia fungi, as well as the acarological analysis for Demodex mites was performed. Results. 4 kinds of Malassezia were revealed on the skin of patients, suffering with SD disease, with dominating M. globosa (10 7 КОЕ/cm 2). At patients, suffering with SD, 2 kinds of mites were revealed: Demodex: D. brevis and D. folliculorum. D. Brevis was dominating - 65%, D.folliculorum - 26%. After affected sites of the facer skin of patients, suffering from SD, with AZP aerosol within 4 weeks was revealed the statically authentic decrease at the average by a factor of 2 from the number of Malassezia yeast, and the decrease (to 16%) of the frequency of D.brevis reveal, аs well as the complete elimination of D.folliculorum. After the course of therapy with topical AZP aerosol is over the high therapeutic effect is revealed at 90% patients with SD. Opinion. So, AZP aerosol can be recommend to the decrease of the number of Malassezia fungi at Demodex mites at the facial skin of patients, suffering with SD.

Possibilities of the modern therapy of acne vulgaris are discussed. The attention is drawn to the fact that in case of the mild and medium disease state the external therapy is emphasized. The role of external antibiotics (clindamycin) and of the azelaic acid was detailed.

The article contains data on the efficiency of ready combined pharmaceuticals in acne treatment and discusses the synergic effect of the new adapalene / benzoyl peroxide combination.

Research target: to evaluate the efficiency and safety of the application of clobetasol propionate ointment (Cloveit ointment for external application, Jelfa) at 60 patients, suffering from plaque psoriasis of average gravity in dermatosis progression phase. Material and methods. The panel comprises 60 patients, suffering from psoriasis (36 men and 24 women) in the age of 25-55 y.o. (the average age is 35,4 ± 2,1 years). The disease continuity was between 6 months and 12 years. The therapeutic efficiency was evaluated with PASI, PGA indices, аs well as with data of ultrasonographic research. Results. Initiating seven days course of the topical therapy with clobetasol propionate, included in the standard comprehensive treatment, favors the transfer of the psoriatic process in the stabilization phase and is not accompanied with clinical and sub-clinical features of skin atrophy.