Vol 91, No 1 (2015)

EDITORIAL

Directions for the development of Vestnik Dermatologii i Venerologii

Kubanova A.A., Kubanov A.A., Karamova A.E.
Vestnik dermatologii i venerologii. 2015;91(1):22-23
pages 22-23 views

Photodynamic therapy for mycosis fungoides: a case series and review of the literature

Hunger R.E., Sallam M., Yawalkar N.

Abstract

Mycosis fungoides (MF) is the most common form of cutaneous T cell lymphoma. In early stages of the disease, topical therapeutic approaches like steroids, chemotherapy, phototherapy or spot radiation therapy are most commonly used. Photodynamic therapy (PDT) is widely executed in the treatment of actinic keratosis and superficial basal cell carcinoma. The effective use of PDT for early forms of MF has been previously demonstrated in a series of cases. In this instance, the treatment of MF (n = 6, 11 lesions) with methyl alanine PDT (MAL-PDT) in 73% of the treated lesions showed a complete response. Within the timeframe of 25-51 months, no recurrence of the successfully treated lesions was observed, on the contrary some of the patients developed new lesions on different sites. Hence, this case study shows that patients having a single or few MF lesions can be successfully treated by PDT.
Vestnik dermatologii i venerologii. 2015;91(1):24-31
pages 24-31 views

Photodynamic therapy with methyl aminolevulinate in the treatment of basal cell carcinoma

Kubanov A.A., Kondrakhina I.N., Gribanov N.V.

Abstract

The article presents the results of the studies on the effectiveness of treatment basal cell carcinoma of the skin with photodynamic therapy with 5-aminolevulinic acid and methyl aminolevulinate. The results of the comparing trials between photodynamic therapy with methyl aminolevulinate and different other treatment modalities are presented.
Vestnik dermatologii i venerologii. 2015;91(1):32-40
pages 32-40 views

Systemic therapy of androgenic alopecia

Kondrakhina I.N., Mareeva A.N.

Abstract

The article describes the literature sources related to the efficacy of systemic therapy of androgenic alopecia in female and male.
Vestnik dermatologii i venerologii. 2015;91(1):41-45
pages 41-45 views

Comparison of methods for diagnostics and treatment of clinical manifestations of the papilloma viral infection

Rakhmatulina M.R., Semenenko A.V.

Abstract

The article describes modern methods for diagnostics of clinical, subclinical and latent forms of the papilloma viral infection. The authors reviewed different methods of the destruction of anogenital warts and described their advantages and shortcomings. They provide the results of studies of the efficacy of Imiquimod for the treatment of anogenital warts.
Vestnik dermatologii i venerologii. 2015;91(1):46-53
pages 46-53 views

GUIDELINES FOR PRACTITIONERS

Rendering medical aid to acne patients. Results of an expert examination of the quality of medical aid

Smirnova I.O., Karachevtseva M.A., Mikhailov S.M., Kulikova Y.A., Kolova I.S., Smirnova T.S., Dudko V.Y., Petunova Y.G., Shin N.V.

Abstract

Goal. To obtain information on typical errors in medical aid rendered to acne patients in dermatovenerology dispensaries in St. Petersburg in order to develop measures to improve the quality of medical aid rendered to this group of patients. Materials and methods. The authors conducted a special expert examination of 55 patients with acne who received treatment at St. Petersburg dermatovenerology dispensaries in 2013. The quality of medical aid was assessed using the Automated Expert Examination Technique (hereinafter referred to as AEET). Major results. The percentage of cases when medical aid of due quality was rendered to acne patients was 49%. Treatment and diagnostics errors prevailed in the structure of errors in medical aid. Errors in treatment were mainly a wrong combination of drugs, simultaneous administration of external and systemic antibacterial drugs, delayed comedolytic therapy and pathogenically infeasible therapy. Errors in diagnostics included absence of indications of the form and/or severity of acne. The most important error in the collection of information was absence of gynecology examinations for women to determine whether peroral contraceptives were necessary including in case of the administration of isotretinoin. Conclusion. The similarity of errors in medical aid rendered for acne as well as high percentage of errors relating to medical aid rendered to patients demand the development of consistent measures to improve the quality of medical aid rendered to such patients and repeated expert examination using preliminary (prompt) control of the quality of medical aid.
Vestnik dermatologii i venerologii. 2015;91(1):76-84
pages 76-84 views

Optical coherence tomography and polarimetry of superficial skin biopsies

Utz S.R., Zimnyakov D.A., Galkina E.M., Reshetnikova E.M.

Abstract

The goal. Of this study was to develop and assess the efficacy of polarization probing of biotissues in vitro. The method is based on the determination of polarization parameters of scattered radiation. Materials and methods. The well-known superficial epidermis stripping method was applied using the Sulfacrylate self-sterile medical adhesive. Small portions of thin layers of the adhesive were applied to slide plates and then to different skin sites. The corneous layer in the normal condition and in case of skin diseases (psoriasis, lichen acuminatus, discoid lupus erythematosus, alopecia, itching and demodectic mange) was examined based on the optical coherence tomography (OCT) method using the 0CS1300SS device (Thorlabs Inc, USA). Results. The authors obtained pictures visualizing the structural organization of different layers of the epidermis using the superficial epidermis biopsy method in case of lichen acuminatus, hyperkeratosis, itching and other skin diseases. Conclusion. This method ensures non-invasive high-precision measurement of the structure of different layers of the epidermis, which may be useful both for research purposes and practical dermatology.
Vestnik dermatologii i venerologii. 2015;91(1):85-91
pages 85-91 views

Efficacy and cosmetic properties of drug forms of hydrocortisone 17-butyrate for patients with allergic contact dermatitis: a prospective observational program

Kubanov A.A., Karamova A.E.

Abstract

Objective. To assess the duration of the therapy needed for complete eradication of clinical manifestations of allergic contact dermatitis (ACD) and evaluate how patients perceive cosmetic properties of Locoid, and to assess etiological factors of ACD based on the medical history. Materials and methods. The authors performed an open multicenter prospective observational program of observations of ACD patients receiving treatment with Locoid (in the form of Lipocream or Crelo). As many as 149 patients were involved. The patients received treatment with Locoid according to the routine practice until complete eradication of the lesions but for not more than 30 days. Prior to the onset of treatment, the etiological factor that caused ACD was evaluated. Upon the completion of the therapy, patients completed questionnaire forms to assess the cosmetic properties of the drug. Results. The authors demonstrated high clinical efficacy of the drug: ACD symptoms were eradicated in 96.64% of the patients; the median treatment duration amounted to 7 days. Cosmetic properties of the drug and general satisfaction with treatment were high regardless of the drug form (Lipocream or Crelo). In the sample under observation, the use of different cosmetic products was the most frequent reason of ACD. High safety of Locoid was demonstrated: adverse events were observed in one patient only. Conclusion. The duration of the therapy needed for complete eradication of clinical manifestations of allergic contact dermatitis is 7 days (median: quartiles of 5-9 days). The perception of cosmetic properties of both Locoid drug forms (Lipocream or Crelo) is positive; general satisfaction with treatment is high and does not depend on the drug form.
Vestnik dermatologii i venerologii. 2015;91(1):104-110
pages 104-110 views

Microbial eczema: up-to-date topical treatment with silver sulfathiazole

Bakulev A.L., Kravchenya S.S., Platonova A.N.

Abstract

Goal. The authors conducted a comparative assessment of the efficacy and safety of 2% silver sulfathiazole in a prospective parallel-group observational study of patients with microbial eczema at the exacerbation stage. Materials and methods. The efficacy of the therapy was assessed on Day 7 and Day 14 based on dynamic calculations of the EASI index and ultrasonic assessment of the intensity of pathological processes in the epidermis and derma; the life quality was assessed based on DLQI and EQ-5D indices, respectively. The microbial composition in the lesions was assessed based on bacterioscopy tests of the contents of blains and erosion fluids. The safety of the therapy was assessed based on the frequency of adverse effects. Results. The administration of 2% silver sulfathiazole arrested both eczematous and pyogenic processes in the lesions within a short period of time, which was confirmed by ultrasonic tests: the depth and density of epidermis and derma were normalized. When applications were performed twice a day, the efficacy with regard to gram-positive bacteria was higher as compared to “classical” topical antibiotics. An evident therapeutic effect with regard to gram-positive bacteria and absence of adverse effects substantially improved the life quality of patients suffering from microbial eczema.
Vestnik dermatologii i venerologii. 2015;91(1):111-121
pages 111-121 views

T* reatment of vulgar and plantar warts

Khlebnikova A.N., Seleznyova Y.V., Dorokhina O.V.

Abstract

The article presents data on clinical forms of warts associated with different types of human papillomavirus. The authors analyze the following wart treatment methods: excision, chemical and immune. Based on literature sources, the authors assess the efficacy, advantages and disadvantages of well-known treatment methods. The authors describe their own experience of treating primary and recurrent vulgar and plantar warts with an up-to-date chemical destruction drug - Mardil Zinc Max, a solution containing a complex compound of 1.5% zinc 2-chloropropionate in 2-chloropropionic acid. The efficacy of treatment of vulgar warts was 100%, and that of plantar ones - 62.5%. Clinical recovery was observed both in case of primary and recurrent processes. The treatment had no adverse effects or complications and was characterized by a low injury rate, good tolerance and full tissue recovery without any cosmetic defects.
Vestnik dermatologii i venerologii. 2015;91(1):122-128
pages 122-128 views

Clinical efficacy, safety and tolerance of the Kerawort (imiquimod) cream used for treatment of anogenital warts

Rakhmatulina M.R., Kubanov A.A., Samtsov A.V., Sukharev A.V., Bondar O.I., Semenenko A.V.

Abstract

Goal of the study. To assess the efficacy and safety of Kerawort (Imiquimod, 5% cream for topical administration) vs. placebo used for treatment of anogenital warts. Methods and materials. The single-blind comparative placebo-controlled study involved 90 patients (44 female and 46 male) with anogenital warts. The patients were randomized into two groups: the main group (n = 45) receiving treatment with Kerawort (Imiquimod, 5% cream) and the control group (n = 45) receiving placebo. The diagnosis was confirmed by the identification of human papillomavirus by the polymerase chain reaction method. The patients received treatment three times a week until clinical signs disappeared but for not more than 16 weeks. Results. In 95.6% of patients from the main group and 8.9% of patients from the control group, anogenital warts disappeared completely or the quantity/area of pathological eruptions reduced at least by 70% as compared to the baseline. No relapses occurred during the treatment and follow-up period (28 days after the completion of treatment) in patients from the main group. An increase in the size and/or area of anogenital warts and/or development of new eruptions on the skin and mucous membrane of the genitals were recorded in 11.1% of patients from the control group. No serious adverse events were revealed during the study. Conclusion. Higher efficacy (р < 0.0000001) and comparable safety of Kerawort (Imiquimod, 5% cream for topical administration) used for treatment of anogenital warts vs. placebo were reliably established.
Vestnik dermatologii i venerologii. 2015;91(1):129-134
pages 129-134 views

AUTHOR'S INDEX OF ARTICLES

Articles published in Vestnik Dermatologii i Venerologii in 2014

Article E.
Vestnik dermatologii i venerologii. 2015;91(1):137-139
pages 137-139 views

Rules for author

Article E.
Vestnik dermatologii i venerologii. 2015;91(1):140-144
pages 140-144 views

Squamous cell carcinoma in a psoriasis patient after multiple courses of phototherapy

Zhilova M.B., Smolyannikova V.A.

Abstract

The authors present a clinical case study of squamous cell carcinoma in a psoriasis patient after 24 courses of phototherapy (22 courses of PUVA therapy and two courses of mid-wavelength ultraviolet therapy (311 nm)). The malignant neoplasm developed against the background of signs of a chronic photodamage of the skin: lentigo, actinic elastosis, diffuse hyperpigmentation, spotty skin pigmentation.
Vestnik dermatologii i venerologii. 2015;91(1):92-98
pages 92-98 views

Early onset of mycosis fungoides. Case from practice

Zaslavsky D.V., Sidikov A.A., Drozdova L.N., Mineeva O.K., Chuprov I.N., Pierre W., Skrek S.V.

Abstract

Clinical and morphological heterogeneity of malignant lymphoproliferative lesions of the skin is explained by the peculiarities of their pathogenesis and organization of the lymphoid tissue in the skin. These features determine the authenticity of therapeutic approaches to patients with this pathology and exclude the use of standard regimens of polychemotherapy used in oncology due to their low efficacy. The authors describe a case study of a suberythrodermic form of mycosis fungoides in a 16-year-old female patient.
Vestnik dermatologii i venerologii. 2015;91(1):99-103
pages 99-103 views

M.F. AHOMGOTOV ON THE 60TH ANNIVERSARY

Article E.
Vestnik dermatologii i venerologii. 2015;91(1):135-136
pages 135-136 views

Personalization of an anti-cytokine therapy of psoriatic patients

Kubanov A.A., Svishchenko S.I.

Abstract

Goal. To develop a personalized approach to the administration of an anti-cytokine therapy to patients suffering from moderate to severe and severe forms of psoriasis based on clinical and immunological parameters. Materials and methods. The authors treated 79 patients suffering from moderate to severe and severe forms of psoriasis vulgaris using anti-cytokine drugs; they assessed the clinical efficacy of the therapy taking into account changes in the PASI index and assessed the levels of cytokines (IL-4, IL-6, IL-17, TNF-α, IL-20, IL-22, IL-31, IL-12, IL-11, IL-18), intercellular adhesion molecules, vascular endothelial growth factor (ICAM-1,VEGF) in the blood serum of patients prior to and in the process of treatment. Results. The authors determined the criteria for a personalized approach to the administration of anti-cytokine drugs.
Vestnik dermatologii i venerologii. 2015;91(1):54-61
pages 54-61 views

Endothelial dysfunction and its treatment in psoriasis patients

Shtoda Y.M., Slesarenko N.A., Bakulev A.L., Utz S.R., Platonova A.N.

Abstract

Goal. To assess the effect of a combined cytostatic therapy and sulodexide on the functional condition of the vascular endothelium in psoriatic patients. Materials and methods. The authors examined 74 patients suffering from psoriasis vulgaris and exudative form of psoriasis. Depending on the treatment option, the patients were subdivided into two groups: Group I (n = 41) receiving a cytostatic therapy and Group II where patients received sulodexide as well. The severity of the endothelium dysfunction was assessed based on laboratory assessments such as nitrogen oxide and endothelin 1 in the blood serum. Results. Prior to the treatment, the level of nitrogen oxide was reduced and endothelin 1 was increased in the blood serum of most patients. Substantial improvement of the pathological process was observed in patients from Group I after the cytostatic therapy (total dose of methotrexate: 100 mg); no normalization of laboratory assessments was observed. In patients from Group II receiving methotrexate (total dose: 40 mg) along with sulodexide, improvement or recovery was observed after the completion of the treatment; endothelium dysfunction was normalized. Conclusion. The inclusion of sulodexide in a complex therapy normalizes endothelial dysfunction in case of psoriasis and reduces the dose and duration of methotrexate treatment.
Vestnik dermatologii i venerologii. 2015;91(1):62-66
pages 62-66 views

Clinical efficacy of the rotation of phototherapy methods (PUVA therapy and mid-wavelength ultraviolet therapy (311 nm)) in patients with moderate to severe forms of psoriasis

Zhilova M.B., Chikin V.V.

Abstract

Goal. To assess the therapeutic efficacy of the rotation of mid-wavelength ultraviolet therapy (311 nm) and PUVA therapy in patients with moderate to severe forms of psoriasis, and to assess the efficacy of mid-wavelength ultraviolet therapy (311 nm) in a multiple-course therapy. Materials and methods. The study involved 66 patients with moderate to severe forms of psoriasis who received multiple courses of treatment by methods of the PUVA therapy and narrowband mid-wavelength phototherapy (311 nm). The patients were divided into three groups: Group 1 (n = 20) - patients who received treatment in the form of mid-wavelength ultraviolet therapy (311 nm) after multiple courses of PUVA therapy; Group 2 (n = 26) - patients who received only multiple courses of PUVA therapy; Group 3 (n = 20) - patients who received only multiple courses of mid-wavelength ultraviolet therapy (311 nm). Results. The authors determined high efficacy (82.8%) of mid-wavelength ultraviolet therapy (311 nm) in patients with moderate to severe forms of psoriasis vulgaris who had previously received multiple courses of PUVA therapy. After multiple courses of long-term treatment by mid-wavelength ultraviolet therapy (311 nm), patients with moderate to severe forms of psoriasis had high efficacy of such multiple courses of treatment (85.78%). Conclusion. Patients with moderate to severe forms of psoriasis who had previously received multiple courses of PUVA therapy can be switched to mid-wavelength ultraviolet therapy (311 nm) with the maintenance of high efficacy of such treatment. The authors observed the absence of any adaptation to the spectral range of mid-wavelength ultraviolet therapy (311 nm) in case of multiple courses of treatment.
Vestnik dermatologii i venerologii. 2015;91(1):67-75
pages 67-75 views

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