Vol 89, No 1 (2013)

Skin melanoma: from systematic biology to the personalized therapy

Ruksha T.G., Aksenenko M.B., Sergeyeva Y.Y., Fefelova Y.A.


Systematic biology is a new field of biomedicine based on the integrative approach to molecular mechanisms of the operation of living systems including in case of the development of pathological processes. In this connection, up-to-date therapeutic approaches to skin melanoma treatment can be considered on the basis of key changes in intermolecular interactions taking place during tumor development.
Vestnik dermatologii i venerologii. 2013;89(1):4-8
pages 4-8 views

Etiology of foot mycosis and onychomycosis

Kozhichkina N.V.


The article presents data from Russian and foreign sources related to the etiology of foot mycosis and onychomycosis. In spite of the substantial spread of data by countries and regions of the world, dermatophytes play a leading part in the etiology of foot mycosis and onychomycosis, and Trichophyton rubrum is found in most studies in more than one half of all cases. Yeast-like fungi of the Candida genus as well as mold fungi belong to less frequent pathogens of foot mycosis. However, they play a greater role in countries with hot and humid climate such as Brazil, Indonesia, Columbia and India. These data are important for the determination of organizational measures aimed at the early diagnostics of patients, timely treatment and implementation of anti-epidemic and disinfectant measures.
Vestnik dermatologii i venerologii. 2013;89(1):9-13
pages 9-13 views

Methods for the determination of M class anti-T. pallidum antibodies for early diagnostics of syphilis

Rotanov S.V., Chuprov-Netochin R.N., Ermatova F.A.


The review covers issues related to the present-day administration of laboratory blood test methods for the determination of specific Class M immunoglobulins against antigens of the syphilis pathogen, T. pallidum (immune-enzyme assay, immunofluorescence reaction, linear immunoblotting). Indications and diagnostic features of the aforesaid medical methods for early diagnostics of acquired or congenital syphilis were determined; cases of reinfection were verified and the intensity of the infection was assessed in the patients who had previously received specific treatment. The article provides recommendations for using specific IgM determination methods described in present-day Russian and foreign guides and standards of syphilis diagnostics.
Vestnik dermatologii i venerologii. 2013;89(1):14-20
pages 14-20 views

Treatment of acne in women ovarian hyperandrogenism and insulin resistance

Golousenko I.Y., Perlamutrov Y.N.


Objective. To determine the efficacy of Glucophage, a biguanide manufactured by MERCK SANTE s.a.s) (France), in the treatment of women with acne, ovarian hyperandrogenism and insulin resistance. Materials and methods. The study involved 65 women aged 20—40, who were administered Glucophage (a biguanide) for a year. The dynamical analysis of acne components and mean values of the acne dermatology index was performed, the therapeutic effect was assessed, and the subjects underwent gynecological and anthropometric examinations as well as laboratory tests: blood hormone level; urine steroid profile; metabolic status; cholesterol, triglycerides and blood biochemistry test as well as ultrasonic examination of small pelvis organs and sebometry. Results. The treatment reduced the acne dermatology index by 89.12%; the therapeutic effect was achieved in 84.62% of the patients; the treatment also produced a positive effect on anthropometric characteristics and resulted in the normalization of the hormonal status, urine steroid profile indices as well as lipid and carbohydrate metabolism, and moderate suppression of the skin fat secretion. Conclusion. The treatment of women suffering from acne, ovarian hyperandrogenism and insulin resistance with Glucophage normalized carbohydrate metabolism, hormonal status and urine steroid profile, which resulted in a positive therapeutic effect on acne.
Vestnik dermatologii i venerologii. 2013;89(1):22-27
pages 22-27 views

Immunohistochemistry detection of kappa-opioid receptors in human skin

Bobko S.I., Lotts T., Metze D., Lvov A.N., Staender S.


The imbalance of p- and kappa-opioid receptors in the skin or central nervous system is currently deemed to be one of the reasons of chronic pruritus. A number of studies demonstrated a positive effect of system agonists of kappa-opioid receptors in the treatment of uremic pruritus, nodular pruritus, paraneoplastic and cholestatic pruritus. This research demonstrates an expression of kappa-opioid receptors in human skin (basal keratinocytes, dendritic cells, epidermal melanocytes and fibroblasts of the upper dermis) detected with the use of different immunochemistry methods.
Vestnik dermatologii i venerologii. 2013;89(1):30-37
pages 30-37 views

Melanocytic nevi in psoriasis patients: results of a study with the use of dermatoscopy

Sergeyeva I.G., Krinitsyna Y.M., Onipchenko V.V., Makarova N.G.


According to the results of a study that involved 32 psoriatic patients, nevi with the diameter exceeding 5 mm are found in 68.8% of patients including 36% of patients with iatrogenic melanoma development risk factors (treatment with methotrexate and phototherapy), 50% of patients with anamnestic (burn injuries including vesication at the age below 18) and 4.5% of patients with inherited risk factors (melanoma in their relatives). As many as 32.4% of the nevi met the dysplastic nevi criteria in the course of the Pehamberger model analysis.
Vestnik dermatologii i venerologii. 2013;89(1):38-43
pages 38-43 views

Program for the evaluation of the quality of medical products for syphilis diagnostics

Kubanov A.A., Rotanov S.V., Frigo N.V.


The article presents quality monitoring data for over 300 batches of medical products for syphilis diagnostics performed by GNTsDK in 2003—2011. It was demonstrated that the result made it possible to ensure the necessary level of the diagnostic efficacy of medical products to be used in medical institutions in the Russian Federation for the purposes of syphilis diagnostics (clinical sensitivity and specificity: min. 95%, reproducibility of results: 100%). To ensure the quality of medical products for diagnosing sexually transmitted diseases including syphilis, FGBU GNTsDK (Ministry of Health Care of the Russian Federation) developed and implemented the Voluntary Quality Control Program for Medical Products for Diagnosing STDs in the Russian Federation in 2006. The Program provides for quality control for batches of medical products, centralized control and information about its results to heads of specialized dermatovenerological medical institutions engaged in syphilis diagnostics, and will also improve the quality of studies for the purposes of syphilis diagnostics using a controlled set of chemicals.
Vestnik dermatologii i venerologii. 2013;89(1):44-50
pages 44-50 views

Langerhans cell histiocytosis (histiocytosis x): a case study

Gorlanov I.A., Zaslavsky D.V., Mineyeva O.K., Leina L.M., Milyavskaya I.R., Peredereyev S.S., Bolshakova Y.S.


The authors provide a case study of Langerhans cell histiocytosis (histiocytosis X) in a two-year-old girl. They describe major stages of the etiology and pathogenesis as well as clinical forms of the disease. Langerhans cell histiocytosis (histiocytosis X) is a rare disease characterized by lesions of the skin and internal organs.
Vestnik dermatologii i venerologii. 2013;89(1):51-55
pages 51-55 views

The experience of treatment of patients suffering from medium and severe acne with the use of isotretinoin

Kungurov N.V., Kokhan M.M., Shabardina O.V.


Ural Research Institute of Dermatovenerology and Immunopathology, Ekaterinburg, Russia Shherbakova street 8, 620076, Ekaterinburg, Russia Objective: assessment of the clinical efficacy and safety of the treatment of patients suffering from acne of different forms of severity with the use of isotretinoin (Acnecutan). Materials and methods. Thirty-two patients with acne underwent treatment and made up 3 groups: 11 patients with the moderate to severe form of acne, 12 patients with the severe form of acne, and 9 patients with acne conglobata. The Basic Acne Severity Index (BASI) was used to assess objective manifestations of the disease. Results: As a result of treatment, the BASI reduced in patients with moderate to severe acne from 25.1 ± 1.6 to 1.5 ± 0.7, in patients with severe acne - from 31.5 ± 2.0 to 1.3 ± 0.8, with acne conglobata - from 45.3 ± 5.2 to 2.8 ± 0.7. Adverse effects that were recorded (such as skin dryness and xerosis, cheilitis and retinoid dermatitis, increased ASAT and ALAT levels in the blood serum) were eliminated with the use of skin care products or by reducing the drug dose. Conclusion: The authors demonstrated high efficacy and safety of Acnecutan in the treatment of patients suffering from acne vulgaris.
Vestnik dermatologii i venerologii. 2013;89(1):56-62
pages 56-62 views

Pathogenetic rationale for the use of skin care products in patients suffering from atopic dermatitis

Dvoryankova Y.V.


Filaggrin is a key protein participating in the differentiation of epidermal cells, which prevents any excessive transepidermal water loss and contributes to the maintenance of skin barrier properties. Mutations in the filaggrin gene (FLG) are among the most important factors predisposing to the development of atopy. Today correct skin care comprising the use of moisturizing and softening products forms an integral part of the therapy for patients with atopic dermatitis and an important component of measures aimed at the reduction of the number of exacerbations and extension of the remission.
Vestnik dermatologii i venerologii. 2013;89(1):63-65
pages 63-65 views

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